公开(公告)号：US20250067021A1

公开(公告)日：2025-02-27

申请号：US18699998

申请日：2022-10-13

Applicant: HIROSHIMA UNIVERSITY ,  KOBELCO CONSTRUCTION MACHINERY CO., LTD.

Inventor： Masatoshi KOZUI ,  Toru YAMAMOTO ,  Hideo YOSHIHARA ,  Kazushige KOIWAI

IPC: E02F9/20

Abstract: A controller of a work machine control system stores a plurality of data groups including manipulation ability past data and control parameter past data associated with the manipulation ability past data, determines manipulation ability of an operator, sets a control parameter using operation information that is information including the manipulation ability and using the plurality of data groups, calculates an assist amount for assisting the manipulation by the operator using the control parameter, calculates a control command for operating an object to be controlled using a manipulation amount of manipulation given to a manipulation device and using the assist amount, and inputs the control command to the object to be controlled.

公开(公告)号：US12213860B2

公开(公告)日：2025-02-04

申请号：US16627660

申请日：2018-06-26

Applicant: Hiroshima University

Inventor： Masayuki Shimada ,  Takashi Umehara ,  Masaaki Goto ,  Moeka Kugumiya

IPC: A61D19/02 ,  C12N5/076 ,  G01N1/40

Abstract: Provided are a method for separating mammalian sperm, by which even a large amount of sperm can be separated in a short time and decrease in motility of the separated sperm can be prevented; and an artificial insemination method, and an in vitro fertilization method. The method for separating mammalian sperm includes incubating the sperm in a medium containing a TLR7 ligand, and separating them into sperm floating in the upper layer and sperm sinking in the lower layer of the medium. The artificial insemination and in vitro fertilization methods include artificial insemination or in vitro fertilization for a non-human mammal using sperm of the non-human mammal separated by the method for separating mammalian sperm.

公开(公告)号：US12180533B2

公开(公告)日：2024-12-31

申请号：US16976267

申请日：2019-03-01

Applicant: HIROSHIMA UNIVERSITY

Inventor： Ryuichi Hirota ,  Akio Kuroda ,  Kei Motomura

IPC: C12Q1/06 ,  C07K14/195 ,  C12N9/02 ,  C12N15/74

Abstract: It is an object of an aspect of the present invention to provide (i) transformants, whose proliferation depends on phosphite, of various species of organism and (ii) a method for detecting the presence of a reduced phosphorous compound with use of such a transformant. Use is made of a transformant which is defective in functions of a gene encoding a phosphate transporter protein and a gene encoding a phosphate ester transporter protein and into which a gene encoding a hypophosphite transporter protein is introduced, a signal peptide of a hypophosphite binding protein being substituted with a signal peptide derived from a host or a species of organism closely related to the host.

公开(公告)号：US20240392537A1

公开(公告)日：2024-11-28

申请号：US18694019

申请日：2022-03-31

Applicant: KOBELCO CONSTRUCTION MACHINERY CO., LTD. ,  HIROSHIMA UNIVERSITY, a university of Japan

Inventor： Ryota SEKIZUKA ,  Masaru ITO ,  Yuichi KURITA

IPC: E02F9/22 ,  E02F9/20 ,  G05G9/047

Abstract: Provided is a system and the like that can improve operability of a manipulation mechanism for an operator. Manipulation reaction forces f1(θ) and f2(φ) acting on manipulation levers 2111 and 2112 are controlled by controlling operation of actuators 214. At this time, the manipulation reaction forces f1(θ) and f2(φ) are controlled to cause reaction forces F1(θ) and F2(φ) in manipulation directions opposite to each other perceived by the operator through manipulation levers 2111 and 2112 (manipulation mechanism) to realize symmetry about a manipulation amount of zero, within a manipulation amount range in a positive manipulation direction and a manipulation amount range in a negative manipulation direction.

公开(公告)号：US20240354947A1

公开(公告)日：2024-10-24

申请号：US18642566

申请日：2024-04-22

Applicant: ADVANCED TELECOMMUNICATIONS RESEARCH INSTITUTE INTERNATIONAL ,  HIROSHIMA UNIVERSITY

Inventor： Giuseppe LISI ,  Jun MORIMOTO ,  Mitsuo KAWATO ,  Takashi YAMADA ,  Naho ICHIKAWA ,  Yasumasa OKAMOTO

IPC: G06T7/00 ,  A61B5/055 ,  G06F18/214 ,  G06F18/2431 ,  G06N20/00 ,  G16H20/70 ,  G16H30/20 ,  G16H50/30 ,  G16H50/70 ,  G16H70/60

CPC classification number: G06T7/0012 ,  G06F18/214 ,  G06F18/2431 ,  G06N20/00 ,  G06T7/0014 ,  G16H20/70 ,  G16H30/20 ,  G16H50/30 ,  G16H50/70 ,  G16H70/60 ,  A61B5/055 ,  G06T2207/10088 ,  G06T2207/20081 ,  G06T2207/30016

Abstract: Objective discrimination of a disease label of a depressive symptom with respect to an active state of a brain is achieved. One means for solving the problems of the present invention is to provide a discriminating device for assisting in determination of whether a subject has a depressive symptom. The discriminating device includes a storage device for storing information for identifying a classifier generated by classifier generation processing based on a signal obtained by using a brain activity detecting apparatus to measure, in advance and time-sequentially, a signal indicating a brain activity of a plurality of predetermined regions of each brain of a plurality of participants in a resting state, the plurality of participants including healthy individuals and patients with depression. The classifier is generated so as to discriminate a disease label of a depressive symptom based on a weighted sum of a plurality of functional connectivities selected by feature selection as being relevant to the disease label of the depressive symptom through machine learning from among functional connectivities of the plurality of predetermined regions. The discriminating device further includes a processor configured to execute discriminating processing of generating a classification result for the depressive symptom of the subject by using the classifier.

公开(公告)号：US20240317804A1

公开(公告)日：2024-09-26

申请号：US18660826

申请日：2024-05-10

Applicant: Astellas Pharma Inc. ,  National Center for Global Health and Medicine ,  Hiroshima University

Inventor： Hideki ENDO ,  Yukihito ISHIZAKA ,  Akira ISHIGURO ,  Tomoki TAKASHINA ,  Takashi YAMAMOTO ,  Tetsushi SAKUMA

IPC: C07K7/06

CPC classification number: C07K7/06

Abstract: An object of the present invention is to provide a cell penetrating peptide having a penetrating ability into cells. The present inventors provided a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 1, a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 2 and a cell penetrating peptide consisting of the amino acid sequence of SEQ ID NO: 3; and a complex comprising any one of the cell penetrating peptide and a functional molecule.

公开(公告)号：US12084835B2

公开(公告)日：2024-09-10

申请号：US17782756

申请日：2020-11-30

Applicant: KOBELCO CONSTRUCTION MACHINERY CO., LTD. ,  HIROSHIMA UNIVERSITY

Inventor： Masaru Ito ,  Yuichi Kurita

IPC: E02F9/20 ,  E02F9/26

CPC classification number: E02F9/205 ,  E02F9/264

Abstract: A remote operation device and a remote operation system that can reduce or eliminate deviation of the position of an indicator image of a working unit such as a line image in an image with respect to the position of the working unit in a real space. In some case, because of a cause such as a communication failure, a position posture coordinate value of a working unit corresponding to captured image data in a work environment image deviates from a position posture coordinate value of the working unit estimated according to an operation form of a remote operation mechanism. In this case, a semitransparent indicator image Img2(τ2) simulating a bucket is superimposed on a work environment image Img1(τ2) in a position where the bucket is estimated to be originally present and deviating from an image region representing the bucket.

公开(公告)号：US20240183131A1

公开(公告)日：2024-06-06

申请号：US18568014

申请日：2022-06-15

Applicant: HIROSHIMA UNIVERSITY ,  KOBELCO CONSTRUCTION MACHINERY CO., LTD.

Inventor： Ryota HASHIMOTO ,  Yasuhiko SHIMAZU ,  Takunori YAMAGUCHI ,  Sho OKIMOTO ,  Kazushige KOIWAI

IPC: E02F9/26 ,  E02F3/32 ,  E02F9/20

CPC classification number: E02F9/262 ,  E02F3/32 ,  E02F9/2004 ,  E02F9/264

Abstract: A hydraulic excavator includes a work attachment a drive unit, a load cell, a machine load calculator, a soil pressure load calculator, and a soil quality estimator. The machine load calculator calculates, from orientation information of the work attachment and information about a load that the drive unit receives, a machine load, which is a load that a bucket receives from earth and sand. The soil pressure load calculator calculates, from a shape of a soil mass, the orientation information, the shape of the bucket, the density of the soil, a wall surface frictional angle, a soil pressure load.

公开(公告)号：US20240092924A1

公开(公告)日：2024-03-21

申请号：US17766789

申请日：2020-10-07

Applicant: RIKEN ,  Hiroshima University

Inventor： Toshitada TAKEMORI ,  Akiko SUGIMOTO ,  Michishige HARADA ,  Mikako SHIROUZU ,  Takehisa MATSUMOTO ,  Tomomi SOMEYA ,  Hiroyuki OSADA ,  Yushi FUTAMURA ,  Kunitada SHIMOTOHNO ,  Hironori NISHITSUJI ,  Kazuaki CHAYAMA ,  Daiki MIKI

IPC: C07K16/28 ,  A61P31/20

CPC classification number: C07K16/2896 ,  A61P31/20 ,  C07K2317/565

Abstract: The present invention provides an antibody that binds to an NTCP, capable of inhibiting infection of human hepatocytes with hepatitis B virus (HBV) particles. The present invention also provides an antibody that binds to an NTCP, capable of inhibiting infection of human hepatocytes with hepatitis B virus (HBV) particles, the antibody having a reduced effect on bile acid transport by NTCP.

公开(公告)号：US11851852B2

公开(公告)日：2023-12-26

申请号：US17270686

申请日：2019-08-29

Applicant: KOBELCO CONSTRUCTION MACHINERY CO., LTD. ,  HIROSHIMA UNIVERSITY

Inventor： Masatoshi Kozui ,  Toru Yamamoto ,  Kazushige Koiwai

IPC: E02F9/26 ,  E02F3/32 ,  E02F3/43

CPC classification number: E02F9/264 ,  E02F3/32 ,  E02F3/435

Abstract: A construction machine includes: a lower travelling body; an upper slewing body attached to the lower travelling body with a structure allowing the upper slewing body to slew with respect to the lower travelling body; a work device attached to the upper slewing body with a structure allowing the work device to swing in a vertical direction with respect to the upper slewing body; a motion state acquisition unit acquiring a motion state amount; an equivalent system forming unit which forms a transfer function which uses a driving force for moving the work device as an input and uses the motion state amount as an output as an equivalent system which equivalently expresses an operation of the work device; and a parameter estimation unit which estimates a system attenuation coefficient and a natural angular frequency of the transfer function as an operation skill evaluation value.