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1.发明授权Carbonyl reductase, gene encoding the same, and process for producing optically active alcohols using the same 有权羰基还原酶，编码其的基因，以及使用其制备光学活性醇的方法公开(公告)号：US07335757B2
公开(公告)日：2008-02-26
申请号：US10943202
申请日：2004-09-17
申请人： Hirotoshi Hiraoka , Makoto Ueda , Mari Hara
发明人： Hirotoshi Hiraoka , Makoto Ueda , Mari Hara
CPC分类号： C12N9/0006 , C12P17/12 , C12Y101/01184
摘要： According to the present invention, there is provided a novel carbonyl reductase derived from a microbial belonging to the genus Ogataea and a DNA encoding the enzyme. By reducing ketones with the use of the carbonyl reductase, optically active alcohols, in particular, (E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid esters can be produced. The carbonyl reductase according to the present invention is excellent in activity and stereoselectivity. Thus, according to the present invention, there is provided a process for producing optically active alcohols, which are industrially useful as intermediate materials for drugs, pesticides, etc.
摘要翻译： 根据本发明，提供了衍生自属于Ogataea属的微生物的新型羰基还原酶和编码该酶的DNA。 通过使用羰基还原酶还原酮，光学活性醇，特别是（E）-7- [2-环丙基-4-（4-氟苯基） - 喹啉-3-基] -3,5-二羟基 - 可以制备庚-6-烯酸酯。 本发明的羰基还原酶的活性和立体选择性优异。 因此，根据本发明，提供了用于制造光学活性醇的方法，其在工业上可用作药物，农药等的中间体材料。
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2.发明申请Novel carbonyl reductase, gene encoding the same, and process for producing optically active alcohols using the same 有权新型羰基还原酶，编码基因的基因，以及使用其的光学活性醇的制造方法公开(公告)号：US20050048633A1
公开(公告)日：2005-03-03
申请号：US10943202
申请日：2004-09-17
申请人： Hirotoshi Hiraoka , Makoto Ueda , Mari Hara
发明人： Hirotoshi Hiraoka , Makoto Ueda , Mari Hara
CPC分类号： C12N9/0006 , C12P17/12 , C12Y101/01184
摘要： According to the present invention, there is provided a novel carbonyl reductase derived from a microbial belonging to the genus Ogataea and a DNA encoding the enzyme. By reducing ketones with the use of the carbonyl reductase, optically active alcohols, in particular, (E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid esters can be produced. The carbonyl reductase according to the present invention is excellent in activity and stereoselectivity. Thus, according to the present invention, there is provided a process for producing optically active alcohols, which are industrially useful as intermediate materials for drugs, pesticides, etc.
摘要翻译： 根据本发明，提供了衍生自属于Ogataea属的微生物的新型羰基还原酶和编码该酶的DNA。 通过使用羰基还原酶还原酮，光学活性醇，特别是（E）-7- [2-环丙基-4-（4-氟苯基） - 喹啉-3-基] -3,5-二羟基 - 可以制备庚-6-烯酸酯。 本发明的羰基还原酶的活性和立体选择性优异。 因此，根据本发明，提供了用于制造光学活性醇的方法，其在工业上可用作药物，农药等的中间体材料。
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3.发明申请公开(公告)号：US20080233621A1
公开(公告)日：2008-09-25
申请号：US10588286
申请日：2005-02-04
CPC分类号： C12P7/04 , C07B2200/07 , C07C51/00 , C07C51/08 , C07C51/09 , C07C67/343 , C07C303/28 , C12P7/40 , C12P7/44 , C07C53/126 , C07C55/02 , C07C69/34 , C07C309/66
摘要： It is an object of the present invention to provide an inexpensive and efficient industrial method for obtaining (S)-2-pentanol, (S)-2-hexanol, 1-methylalkyl malonic acid and 3-methyl carboxylic acid at a high optical purity. The present invention provides a method of producing (S)-2-pentanol or (S)-2-hexanol which comprises allowing certain types of microorganisms or transformed cells, a product obtained by treating said microorganisms or cells, a culture solution of said microorganisms or cells, and/or a crude purified product or purified product of a carbonyl reductase fraction obtained from said microorganisms or cells, to act on 2-pentanone or 2-hexanone.
摘要翻译： 本发明的目的是提供一种廉价且高效的工业方法，以高光学纯度获得（S）-2-戊醇，（S）-2-己醇，1-甲基烷基丙二酸和3-甲基羧酸 。 本发明提供一种生产（S）-2-戊醇或（S）-2-己醇的方法，其包括将某些类型的微生物或转化细胞，即通过处理所述微生物或细胞获得的产物，所述微生物或转化细胞的培养液 或细胞，和/或粗制纯化产物或由所述微生物或细胞获得的羰基还原酶级分的纯化产物作用于2-戊酮或2-己酮。
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