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公开(公告)号：US09229003B2
公开(公告)日：2016-01-05
申请号：US12503434
申请日：2009-07-15
Applicant: Johji Inazawa , Issei Imoto , Takaya Ishihara , Hitoshi Tsuda
Inventor： Johji Inazawa , Issei Imoto , Takaya Ishihara , Hitoshi Tsuda
IPC: C12Q1/68 , C12Q1/70 , C12P19/34 , G01N33/574
CPC classification number: G01N33/57407 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156
Abstract: It is an object of the present invention to identify a gene that exhibits behavior which is characteristic of carcinomas such as thyroid carcinoma, so as to provide a method for detecting carcinoma and a cell growth suppressing agent. The present invention provides a method for detecting carcinoma, which comprises detecting malignant transformation by detecting at least one alteration of gene existing in chromosomal regions 1q41, 3q28, 7q31.2, 8p12, 8q22.2, 8q24.21, 11q4.1, 17q12, 20q11, 9p21.3, 16q13.2, and 16q23.1 in a specimen.
Abstract translation: 本发明的目的是鉴定表现出甲状腺癌等癌症特征的基因，从而提供检测癌症和细胞生长抑制剂的方法。 本发明提供了一种检测癌症的方法，其包括通过检测染色体区域1q41，3q28,7q31.2,8p12,8q22.2,8q24.21,11q4.1,17q12中存在的基因的至少一个改变来检测恶性转化 ，20q11,9p21.3,16q13.2和16q23.1。
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2.发明申请公开(公告)号：US20140018248A1
公开(公告)日：2014-01-16
申请号：US12730919
申请日：2010-03-24
Applicant: Johji INAZAWA , Issei Imoto , Shuhei Komatsu , Ken-ichi Kozaki , Hitoshi Tsuda
Inventor： Johji INAZAWA , Issei Imoto , Shuhei Komatsu , Ken-ichi Kozaki , Hitoshi Tsuda
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q1/6837 , C12Q2600/112 , C12Q2600/118
Abstract: An object of the present invention is to provide a method for detecting cancer and an agent for suppressing cell growth by identification of genes showing behaviors characteristic in cancer such as esophageal carcinoma. The present invention provides a method for detecting cancer, which comprises detecting canceration through detection of amplification of at least one gene existing in an 1q32-1q41 chromosomal region in a specimen.
Abstract translation: 本发明的目的是提供一种通过鉴定显示食管癌等癌症行为特征的基因来检测癌症的方法和抑制细胞生长的药剂。 本发明提供了一种检测癌症的方法，其包括通过检测样品中1q32-1q41染色体区域中存在的至少一个基因的扩增来检测癌变。
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公开(公告)号：US20100035262A1
公开(公告)日：2010-02-11
申请号：US12503434
申请日：2009-07-15
Applicant: Johji Inazawa , Issei Imoto , Takaya Ishihara , Hitoshi Tsuda
Inventor： Johji Inazawa , Issei Imoto , Takaya Ishihara , Hitoshi Tsuda
CPC classification number: G01N33/57407 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156
Abstract: It is an object of the present invention to identify a gene that exhibits behavior which is characteristic of carcinomas such as thyroid carcinoma, so as to provide a method for detecting carcinoma and a cell growth suppressing agent. The present invention provides a method for detecting carcinoma, which comprises detecting malignant transformation by detecting at least one alteration of gene existing in chromosomal regions 1q41, 3q28, 7q31.2, 8p12, 8q22.2, 8q24.21, 11q4.1, 17q12, 20q11, 9p21.3, 16q13.2, and 16q23.1 in a specimen.
Abstract translation: 本发明的目的是鉴定表现出甲状腺癌等癌症特征的基因，从而提供检测癌症和细胞生长抑制剂的方法。 本发明提供了一种检测癌症的方法，其包括通过检测染色体区域1q41，3q28,7q31.2,8p12,8q22.2,8q24.21,11q4.1,17q12中存在的基因的至少一个改变来检测恶性转化 ，20q11,9p21.3,16q13.2和16q23.1。
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Patent Agency Ranking
4.发明授权公开(公告)号：US09090942B2
公开(公告)日：2015-07-28
申请号：US12730919
申请日：2010-03-24
Applicant: Johji Inazawa , Issei Imoto , Shuhei Komatsu , Ken-ichi Kozaki , Hitoshi Tsuda
Inventor： Johji Inazawa , Issei Imoto , Shuhei Komatsu , Ken-ichi Kozaki , Hitoshi Tsuda
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q1/6837 , C12Q2600/112 , C12Q2600/118
Abstract: An object of the present invention is to provide a method for detecting cancer and an agent for suppressing cell growth by identification of genes showing behaviors characteristic in cancer such as esophageal carcinoma. The present invention provides a method for detecting cancer, which comprises detecting canceration through detection of amplification of at least one gene existing in an 1q32-1q41 chromosomal region in a specimen.
Abstract translation: 本发明的目的是提供一种通过鉴定显示食管癌等癌症行为特征的基因来检测癌症的方法和抑制细胞生长的药剂。 本发明提供了一种检测癌症的方法，其包括通过检测样品中1q32-1q41染色体区域中存在的至少一个基因的扩增来检测癌变。
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公开(公告)号：US20110015144A1
公开(公告)日：2011-01-20
申请号：US12934146
申请日：2009-01-26
Applicant: Masakazu Toi , Hiroji Iwata , Katsumasa Kuroi , Seigo Nakamura , Shinji Ohno , Norikazu Masuda , Kenjiro Aogi , Nobuaki Sato , Futoshi Akiyama , Masafumi Kurosumi , Hitoshi Tsuda
Inventor： Masakazu Toi , Hiroji Iwata , Katsumasa Kuroi , Seigo Nakamura , Shinji Ohno , Norikazu Masuda , Kenjiro Aogi , Nobuaki Sato , Futoshi Akiyama , Masafumi Kurosumi , Hitoshi Tsuda
IPC: A61K31/704 , G06Q50/00 , A61P35/00
CPC classification number: A61K31/337 , A61K31/513 , A61K31/675 , A61K31/704 , C07K14/71 , C07K14/721 , G01N2333/71 , G01N2333/723 , G06F19/00 , G06F19/3456 , G06Q50/22 , G16H10/20
Abstract: There was no device that proposes a method for administrating anti-cancer drugs according to each of cancer types.An administration method proposing device (100) includes an input unit (101) that receives an input of the cancer type of a cancer patient, an administration procedure determination unit (102) that determines the administration order of an FEC (F: 5-fluorouracil, E: epirubicin, and C: cyclophosphamide) administration cycle and a docetaxel administration cycle, and a display unit (103) that displays the administration order of the FEC administration cycle and the docetaxel administration cycle, as a result of the determination by the administration procedure determination unit (102).
Abstract translation: 没有提出根据癌症类型给予抗癌药物的方法的装置。 管理方法提出装置（100）包括接收癌症患者的癌症类型的输入的输入单元（101），确定FEC（F：5-氟尿嘧啶（F））的给药顺序的给药程序确定单元 ，E：表柔比星和C：环磷酰胺）给药周期和多西紫杉醇给药周期，以及显示单位（103），其显示了FEC给药周期和多西紫杉醇给药周期的给药顺序，作为由给药 过程确定单元（102）。
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公开(公告)号：US20100035758A1
公开(公告)日：2010-02-11
申请号：US12430639
申请日：2009-04-27
Applicant: JOHJI INAZAWA , ISSEI IMOTO , ERINA NAKAMURA , HITOSHI TSUDA
Inventor： JOHJI INAZAWA , ISSEI IMOTO , ERINA NAKAMURA , HITOSHI TSUDA
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
Abstract: It is an object to be achieved by the present invention to provide a method for detecting cancer and a cell growth inhibiting agent by the identification of genes exhibiting characteristic behavior in cancers such as oral squamous-cell carcinoma. The present invention provides a method for detecting cancer, which comprises detecting at least one gene alteration existing in chromosomal region 4q35 in a specimen.
Abstract translation: 本发明的目的是提供一种通过鉴定在诸如口腔鳞状细胞癌等癌症中表现出特征性行为的基因来检测癌症和细胞生长抑制剂的方法。 本发明提供了一种检测癌症的方法，其包括检测样品中染色体区域4q35中存在的至少一种基因改变。
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公开(公告)号：US08865663B2
公开(公告)日：2014-10-21
申请号：US12934146
申请日：2009-01-26
Applicant: Masakazu Toi , Hiroji Iwata , Katsumasa Kuroi , Seigo Nakamura , Shinji Ohno , Norikazu Masuda , Kenjiro Aogi , Nobuaki Sato , Futoshi Akiyama , Masafumi Kurosumi , Hitoshi Tsuda
Inventor： Masakazu Toi , Hiroji Iwata , Katsumasa Kuroi , Seigo Nakamura , Shinji Ohno , Norikazu Masuda , Kenjiro Aogi , Nobuaki Sato , Futoshi Akiyama , Masafumi Kurosumi , Hitoshi Tsuda
IPC: A61K31/704 , G06Q50/00 , A61P35/00 , A61K31/337 , C07K14/71 , C07K14/72 , A61K31/513 , A61K31/675 , G06F19/00 , G06Q50/22
CPC classification number: A61K31/337 , A61K31/513 , A61K31/675 , A61K31/704 , C07K14/71 , C07K14/721 , G01N2333/71 , G01N2333/723 , G06F19/00 , G06F19/3456 , G06Q50/22 , G16H10/20
Abstract: An administration method comprising: determining a cancer type through (i) first data indicating that an Estrogen Receptor (ER) is negative and a Human Epidermal growth factor Receptor-2 (Her2) is negative, or (ii) second data indicating that at least one of the ER and the Her2 is positive; and when the cancer type is determined through (i) the first data indicating that the ER is negative and the Her2 is negative: first performing a docetaxel administration cycle comprising administrating docetaxel to a patient multiple times at certain intervals; and then performing a 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) administration cycle comprising administrating 5-fluorouracil, epirubicin, and cyclophosphamide to the patient multiple times at certain intervals, and when the cancer type is determined through (ii) the second data indicating that at least one of the ER and Her2 is positive: first performing the FEC administration cycle; and then performing the docetaxel administration cycle.
Abstract translation: 一种给药方法，包括：通过（i）表示雌激素受体（ER）为阴性的第一数据和人表皮生长因子受体-2（Her2）为阴性，或（ii）表示至少 ER和Her2之一是积极的; 并且当通过（i）表示ER为阴性且Her2为阴性的第一数据确定癌症类型时：首先进行多西紫杉醇给药循环，包括以特定间隔多次给予患者多西紫杉醇; 然后进行5-氟尿嘧啶，表柔比星和环磷酰胺（FEC）施用周期，其包括以一定间隔多次施用5-氟尿嘧啶，表柔比星和环磷酰胺，并且当通过（ii）第二数据确定癌症类型时 表示ER和Her2中的至少一个是阳性的：首先执行FEC管理周期; 然后进行多西他赛给药周期。
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公开(公告)号：US08143003B2
公开(公告)日：2012-03-27
申请号：US12430639
申请日：2009-04-27
Applicant: Johji Inazawa , Issei Imoto , Erina Nakamura , Hitoshi Tsuda
Inventor： Johji Inazawa , Issei Imoto , Erina Nakamura , Hitoshi Tsuda
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
Abstract: It is an object to be achieved by the present invention to provide a method for detecting cancer and a cell growth inhibiting agent by the identification of genes exhibiting characteristic behavior in cancers such as oral squamous-cell carcinoma. The present invention provides a method for detecting cancer, which comprises detecting at least one gene alteration existing in chromosomal region 4q35 in a specimen.
Abstract translation: 本发明的目的是提供一种通过鉴定在诸如口腔鳞状细胞癌等癌症中表现出特征性行为的基因来检测癌症和细胞生长抑制剂的方法。 本发明提供了一种检测癌症的方法，其包括检测样品中染色体区域4q35中存在的至少一种基因改变。
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