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公开(公告)号：US07812022B2
公开(公告)日：2010-10-12
申请号：US11721504
申请日：2005-12-06
申请人： David Edward Uehling , Kirk Lawrence Stevens , Scott Howard Dickerson , Alex Gregory Waterson , Philip Anthony Harris , Douglas McCord Sammond , Robert Dale Hubbard , Holly Kathleen Emerson , Joseph W. Wilson
发明人： David Edward Uehling , Kirk Lawrence Stevens , Scott Howard Dickerson , Alex Gregory Waterson , Philip Anthony Harris , Douglas McCord Sammond , Robert Dale Hubbard , Holly Kathleen Emerson , Joseph W. Wilson
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.
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2.发明申请公开(公告)号：US20090326029A1
公开(公告)日：2009-12-31
申请号：US12303119
申请日：2007-05-31
IPC分类号： A61K31/4184 , C07D235/04 , A61P35/00
CPC分类号： C07D409/04
摘要： The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译： 本发明提供苯并咪唑噻吩化合物，其含有它们的药物组合物，其制备方法及其作为药剂的用途。
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公开(公告)号：US07338959B2
公开(公告)日：2008-03-04
申请号：US10506447
申请日：2003-02-28
申请人： Stanley Dawes Chamberlain , Mui Cheung , Holly Kathleen Emerson , Neil W. Johnson , Kristen Elizabeth Nailor , Douglas McCord Sammond , Marcus Semones
发明人： Stanley Dawes Chamberlain , Mui Cheung , Holly Kathleen Emerson , Neil W. Johnson , Kristen Elizabeth Nailor , Douglas McCord Sammond , Marcus Semones
IPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , A61K31/506 , A61K31/4184 , A61P35/00
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译： 本文描述了可用作TIE-2和/或VEGFR-2抑制剂的苯并咪唑衍生物。 所述的发明还包括制备这种苯并咪唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。
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公开(公告)号：US07491731B2
公开(公告)日：2009-02-17
申请号：US11430342
申请日：2006-05-09
IPC分类号： C07D239/49 , A61K31/505
CPC分类号： C12N9/12 , C07K14/7153 , C07K2299/00 , G06F19/16
摘要： A crystal structure of the cfms kinase domain, co-crystal structure with a bound small molecule, as well as methods of using the same in the discovery of cfms inhibitors and in the treatment of diseases mediated by inappropriate cfms activity.
摘要翻译： 具有结合的小分子的cfms激酶结构域，共晶体结构的晶体结构，以及在发现cfms抑制剂以及治疗由不适当cfms活性介导的疾病的治疗方法。
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