公开(公告)号：US4746490A

公开(公告)日：1988-05-24

申请号：US827174

申请日：1986-02-06

申请人： Hossain H. Saneii

发明人： Hossain H. Saneii

IPC分类号： B01J19/00 ,  C40B40/10 ,  C40B60/14 ,  C07K1/08 ,  C12M1/00 ,  G05B17/00

CPC分类号： B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00488 ,  B01J2219/005 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00725 ,  C40B40/10 ,  C40B60/14 ,  Y10T436/12

摘要： An apparatus for peptide synthesis in which a plurality of supply valves are arranged in series to define a line for supplying successive reagents to a reaction vessel in which a peptide is to be synthesized. A corresponding plurality of containers contain respective reagents and each, by actuation of its corresponding valve, is connectable through downstream ones of the series of valves to supply its respective reagent to the reaction vessel. For cleaning or reacting with peptide starting material therein further valving permits draining of the reaction vessel to waste and, between applications of successive reagents to the reaction vessel, cleaning of the line of valves by flushing with a cleaning reagent sent from the upstream end of the series of valves through the line to waste. In modified embodiments, the plurality of reagent containers and series line of valves supplies reagents to multiple reaction vessel chambers in such a way that the multiple chamber may simultaneously be occupied by the same reagent in one peptide synthesis step and by several differing reagents, delivered thereto in sequence, in a differing peptide synthesis step, to enable simultaneous production of similar but different peptide analogs.

摘要翻译： 一种用于肽合成的装置，其中多个供应阀串联布置以限定用于向要合成肽的反应容器提供连续试剂的管线。 相应的多个容器包含各自的试剂，并且通过其相应的阀的致动，可以通过下游的一系列阀连接以将其各自的试剂供应到反应容器。 为了清洗或与肽原料反应，其中进一步的阀门允许将反应容器排放到废物中，并且在连续试剂施加到反应容器之间，通过用从上游端的反应器 系列阀门通过线路浪费。 在改进的实施方案中，多个试剂容器和串联的管线将试剂供给到多个反应容器室，使得多个反应室可以在一个肽合成步骤中同时被同一试剂占据，并通过几种不同的试剂被递送 顺序地，在不同的肽合成步骤中，以使得能够同时产生相似但不同的肽类似物。

公开(公告)号：US4880781A

公开(公告)日：1989-11-14

申请号：US147073

申请日：1988-01-20

申请人： Jackson B. Hester, Jr. ,  Suvit Thaisrivongs ,  Tomi K. Sawyer ,  Ruth E. TenBrink ,  Hossain H. Saneii ,  Heinrich J. Schostarez ,  Donald T. Pals

发明人： Jackson B. Hester, Jr. ,  Suvit Thaisrivongs ,  Tomi K. Sawyer ,  Ruth E. TenBrink ,  Hossain H. Saneii ,  Heinrich J. Schostarez ,  Donald T. Pals

IPC分类号： C07K5/02 ,  C12Q1/37 ,  G01N33/573 ,  G01N33/68

CPC分类号： C07K5/0227 ,  C12Q1/37 ,  G01N33/573 ,  G01N33/6893 ,  G01N2333/96472 ,  G01N2800/321 ,  Y10S530/86

摘要： The present invention provides novel renin-inhibiting peptides and novel processes and intermediates for the preparation of both novel and known renin-inhibiting peptide analogs. Such inhibitors are useful for the diagnosis and control of renin-dependent hypertension.

摘要翻译： 本发明提供新的肾素抑制肽和用于制备新型和已知的肾素抑制性肽类似物的新方法和中间体。 这种抑制剂可用于诊断和控制肾素依赖性高血压。