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公开(公告)号：US20100286174A1
公开(公告)日：2010-11-11
申请号：US12782059
申请日：2010-05-18
IPC分类号： A61K31/519 , A61K31/405 , A61K31/402 , A61P11/00 , A61P9/10 , A61P9/00 , A61P13/12
CPC分类号： A61K31/40
摘要： Treatment of myocardial infarction to reduce infarct size and organogenesis is provided by administration of agents selected from the group consisting of
摘要翻译： 通过施用选自以下的药剂提供心肌梗塞的治疗以减少梗死面积和器官发生：
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公开(公告)号：US20110288149A1
公开(公告)日：2011-11-24
申请号：US13067013
申请日：2011-05-02
IPC分类号： A61K31/713 , C07K2/00 , A61P9/00 , C12Q1/48 , A01K67/027
CPC分类号： C07K14/47 , C12Q1/485 , G01N33/5008 , G01N33/5061 , G01N2333/9121
摘要： The present invention relates, in general, to heart failure, and, in particular to a method of reducing the risk of heart failure, particularly in patents with established cardiomyopathy.
摘要翻译： 本发明一般涉及心力衰竭，特别涉及降低心力衰竭风险的方法，特别是在具有确立的心肌病的专利中。
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公开(公告)号：US07060871B2
公开(公告)日：2006-06-13
申请号：US10183344
申请日：2002-06-28
IPC分类号： A01K67/033 , A01K67/027 , G01N33/00 , C12N15/63 , C12N15/00
CPC分类号： C12N9/1205 , A61K31/70 , A61K38/1787 , A61K48/00
摘要： The present invention deals with gene therapy for treating chronic heart failure and other cardiac disease states which are accompanied by a reduced number or functioning of myocardial beta-adrenergic receptors (β-AR). β-AR receptor function is augmented in transgenic animals by delivery and expression of a beta-2-adrenergic receptor gene or a gene encoding a beta adrenergic receptor kinase inhibitor, resulting in increased in vivo left ventricular function. The present invention includes recombinant plasmid vectors, alternative beta-adrenergic receptor gene delivery strategies, and transgenic mice carrying a β-AR transgene, a β-ARK transgene, or a β-ARK inhibitor transgene.
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