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    USE OF AN AGENT THAT RESTORES TISSUE PERFUSION AND OXYGENATION
    4.
    发明申请
    USE OF AN AGENT THAT RESTORES TISSUE PERFUSION AND OXYGENATION 有权
    使用恢复组织灌注和氧化的药剂

    公开(公告)号：US20120225133A1

    公开(公告)日：2012-09-06

    申请号：US13449932

    申请日：2012-04-18

    申请人： Mark W. Dewhirst ,  Jonathan S. Stamler ,  Timothy J. McMahon ,  Pierre Sonveaux

    发明人： Mark W. Dewhirst ,  Jonathan S. Stamler ,  Timothy J. McMahon ,  Pierre Sonveaux

    IPC分类号： A61K33/00 ,  A61P3/10 ,  A61P9/10 ,  A61P29/00 ,  A61P25/00 ,  A61P35/00 ,  A61P1/16

    CPC分类号： A61K38/1709 ,  A61K31/21 ,  A61K33/00 ,  A61K35/18 ,  A61K38/00 ,  A61K38/42 ,  A61K45/06 ,  A61K47/08 ,  A61K47/16 ,  A61K47/6445 ,  A61K2300/00

    摘要： The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.

    摘要翻译： 目前公开的主题提供了在受试者的组织的缺氧区域中增加灌注的方法。 还提供了用于治疗受试者与缺氧相关的疾病和/或病症的方法，用于增加肿瘤对放射和/或化疗治疗的敏感性的方法，用于延迟受试者的肿瘤生长的方法，以及用于抑制受试者的肿瘤血管生长的方法。 在一些实施方案中，本发明公开的方法包括向有需要的受试者施用选自亚硝基化血红蛋白和诱导受试者内源性血红蛋白亚硝基化的试剂的第一组合物和包含高氧气体的第二组合物。 在一些实施方案中，本发明公开的方法还包括用放射治疗，化疗，光动力疗法，免疫治疗或其组合治疗肿瘤。 还提供了可在本公开的方法中使用的可吸入气体。

    Use of an agent that restores tissue perfusion and oxygenation
    5.
    发明授权
    Use of an agent that restores tissue perfusion and oxygenation 有权
    使用恢复组织灌注和氧合的药物

    公开(公告)号：US08198241B2

    公开(公告)日：2012-06-12

    申请号：US12847330

    申请日：2010-07-30

    申请人： Mark W. Dewhirst ,  Jonathan S. Stamler ,  Timothy J. McMahon ,  Pierre Sonveaux

    发明人： Mark W. Dewhirst ,  Jonathan S. Stamler ,  Timothy J. McMahon ,  Pierre Sonveaux

    IPC分类号： A61K38/00 ,  A61K33/00

    CPC分类号： A61K38/1709 ,  A61K31/21 ,  A61K33/00 ,  A61K35/18 ,  A61K38/00 ,  A61K38/42 ,  A61K45/06 ,  A61K47/08 ,  A61K47/16 ,  A61K47/6445 ,  A61K2300/00

    摘要： The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.

    摘要翻译： 目前公开的主题提供了在受试者的组织的缺氧区域中增加灌注的方法。 还提供了用于治疗受试者与缺氧相关的疾病和/或病症的方法，用于增加肿瘤对放射和/或化疗治疗的敏感性的方法，用于延迟受试者的肿瘤生长的方法，以及用于抑制受试者的肿瘤血管生长的方法。 在一些实施方案中，本发明公开的方法包括向有需要的受试者施用选自亚硝基化血红蛋白和诱导受试者内源性血红蛋白亚硝基化的试剂的第一组合物和包含高氧气体的第二组合物。 在一些实施方案中，本发明公开的方法还包括用放射治疗，化疗，光动力疗法，免疫治疗或其组合治疗肿瘤。 还提供了可在本公开的方法中使用的可吸入气体。

    Proteomic interaction and genomic action determinations in the presence of associated redox state conditions
    6.
    发明授权
    Proteomic interaction and genomic action determinations in the presence of associated redox state conditions 有权
    蛋白质组学相互作用和相关氧化还原状态条件下的基因组作用测定

    公开(公告)号：US08039217B2

    公开(公告)日：2011-10-18

    申请号：US12037411

    申请日：2008-02-26

    申请人： Jonathan S. Stamler

    发明人： Jonathan S. Stamler

    IPC分类号： C12Q1/68 ,  G01N33/569 ,  C12N15/09

    CPC分类号： C12Q1/6809 ,  G01N33/5091 ,  G01N33/6803 ,  Y10S977/924

    摘要： Genomic actions and/or proteomic interactions for pathophysiological processes and for physiological processes are determined at associated redox state conditions. Protein interactions are correlated with oxygen tensions. Identification of markers for disease including epitopes is effected in the presence of simulated redox state perturbations. Screening for previously unknown receptors and activating ligands is carried out in the presence of alteration of redox state.

    摘要翻译： 在相关的氧化还原状态下测定病理生理过程和生理过程的基因组作用和/或蛋白质组学相互作用。 蛋白质相互作用与氧气张力相关。 在模拟氧化还原状态扰动的情况下，鉴定包括表位的疾病的标志物。 在先前未知的受体和活化配体的筛选在氧化还原状态改变的情况下进行。

    No-modified hemoglobins and uses therefor
    9.
    发明申请
    No-modified hemoglobins and uses therefor 审中-公开
    无改性血红蛋白及其用途

    公开(公告)号：US20090253615A1

    公开(公告)日：2009-10-08

    申请号：US12386674

    申请日：2009-04-21

    申请人： Jonathan S. Stamler

    发明人： Jonathan S. Stamler

    IPC分类号： A61K38/42

    CPC分类号： A61K31/00 ,  A61K31/04 ,  A61K31/095 ,  A61K31/195 ,  A61K35/18 ,  A61K38/00 ,  A61K38/44 ,  A61K47/6445 ,  A61K47/6901 ,  C07K14/00 ,  C07K14/805 ,  G01N21/631 ,  G01N21/76 ,  G01N33/721 ,  Y10T436/105831

    摘要： Nitrosylhemoglobin can be produced by introducing gaseous NO into an aqueous solution of hemoglobin. It has been demonstrated that nitrosylhemoglobin in aqueous solution can be converted to SNO-hemoglobin upon introduction of oxygen to the solution, as is postulated to occur in the lungs. Nitrosylhemoglobin can be used in methods to produce the physiological effects of NO, for example, to reduce vasoconstriction and to inhibit platelet aggregation.

    摘要翻译： 可以通过将气态NO引入血红蛋白水溶液中来产生亚硝基血红蛋白。 已经证明，如将假定在肺中发生的那样将氧气引入溶液中，则可将水溶液中的亚硝基血红蛋白转化为SNO-血红蛋白。 硝基血红蛋白可用于产生NO的生理作用的方法，例如减少血管收缩和抑制血小板聚集。