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23 条记录 (耗时 0.012 秒)

    Free radicals
    1.
    发明授权
    Free radicals 失效
    自由基

    公开(公告)号：US5530140A

    公开(公告)日：1996-06-25

    申请号：US220522

    申请日：1994-03-31

    申请人： Sven Andersson ,  Finn Radner ,  Anna Rydbeek ,  Rolf Servin ,  Lars-Goran Wistrand

    发明人： Sven Andersson ,  Finn Radner ,  Anna Rydbeek ,  Rolf Servin ,  Lars-Goran Wistrand

    IPC分类号： A61K49/20 ,  C07B60/00 ,  C07D493/04 ,  C07D495/04 ,  C07D497/04 ,  C07D519/00 ,  A61K49/00

    CPC分类号： C07D493/04 ,  A61K49/20 ,  C07B61/02 ,  C07D495/04 ,  C07D497/04

    摘要： The invention provides novel persistent free radicals useful in Overhauser MRI being triarylmethyl radicals having as at least one aryl group a group of formula ##STR1## (wherein each X which may be the same or different is an oxygen or sulphur atom or a group CO or S(O).sub.n, (where n is 1 to 3) with the proviso that at least one group X is a sulphur atom or a S(O).sub.n group; R.sup.1 is a hydrogen atom or group of formula --M, --XM, --X--Ar.sup.2, or --Ar.sup.2 where M is a water solubilizing group, and Ar.sup.2 represents a 5-10 membered aromatic ring optionally substituted by a water solubilizing group M; and each of the groups R.sup.7, which may be the same or different, is a hydrogen atom, or a hydrocarbon group or a water solubilizing group M, or two groups R.sup.7 together with the atom to which they are bound represent a carbonyl group or a 5 to 8 membered cycloalkylidene, mono- or di-oxacycloalkylidene, mono- or di-azacycloalkylidene or mono- or di-thiacycloalkylidene group optionally with the ring attachment carbon replaced by a silicon atom, and R.sup.7 where it is other than hydrogen, is optionally substituted by a hydroxyl group, an optionally alkoxylated, optionally hydroxylated acyloxy or alkyl group or a water solubilizing group M)). The novel radicals have good stability, long relaxation times and good relaxivity.

    摘要翻译： 本发明提供了在Overhauser MRI中有用的新型持久性自由基，其具有作为至少一个芳基的基团为具有下式的基团的三芳基甲基（其中可以相同或不同的X是氧或硫原子或 基团CO或S（O）n，（其中n为1至3），条件是至少一个基团X为硫原子或S（O）n基团; R 1为氢原子或式-M ，-XM，-X-Ar2或-Ar2，其中M是水溶性基团，Ar2表示任选被水增溶基团M取代的5-10元芳香环;并且各基团R7可以是 相同或不同的是氢原子，或烃基或水溶性基团M，或两个R 7与它们所连接的原子一起代表羰基或5-8元环亚烷基，单 - 或二 - 单环或二氮杂环亚烷基或任选具有环连接c的单 - 或二 - 芳烃被硅原子取代，并且其中不是氢的R 7任选被羟基取代，任选烷氧基化，任选羟基化的酰氧基或烷基或水溶性基团M））。 新型自由基具有良好的稳定性，较长的松弛时间和良好的松弛性。

    Selective isotopic labeling of spin labels for electron spin resonance spectroscopy
    2.
    发明授权
    Selective isotopic labeling of spin labels for electron spin resonance spectroscopy 失效
    电子自旋共振光谱自旋标记的选择性同位素标记

    公开(公告)号：US5431901A

    公开(公告)日：1995-07-11

    申请号：US227793

    申请日：1988-08-03

    申请人： Howard J. Halpern ,  Beverly A. Teicher

    发明人： Howard J. Halpern ,  Beverly A. Teicher

    IPC分类号： A61K49/20 ,  C07B60/00 ,  C07D207/46 ,  C07D211/94

    CPC分类号： A61K49/20 ,  C07B61/02 ,  C07D207/46 ,  Y10T436/24

    摘要： Selective isotopic-labeling of spin label compounds, used in electron spin resonance spectroscopy to detect, measure and monitor the presence of paramagnetic species, increases the sensitivity of the electron spin resonance technique in assays for paramagnetic species, such as the determination of oxygen tension in solution or in a biological sample, like a living organism. Spin label compounds, such as nitroxides, like 3-carbamoyl-2,2,5,5-tetramethyl-3-pyrroline-1-yloxyl (CTPO), are selectively, but not completely, isotopically-labeled, such as partially deuterated, to increase the sensitivity and reliability of assays employing electron spin resonance spectroscopic measurements.

    摘要翻译： 用于电子自旋共振光谱法的自旋标记化合物的选择性同位素标记用于检测，测量和监测顺磁性物质的存在，增加了电子自旋共振技术在顺磁性物质的测定中的灵敏度，例如测定氧气张力 溶液或生物样品，如活体。 旋转标记化合物，例如硝基氧，如3-氨基甲酰基-2,2,5,5-四甲基-3-吡咯啉-1-基氧基（CTPO），是选择性但不完全同位素标记的，例如部分氘代， 以提高使用电子自旋共振光谱测量的测定的灵敏度和可靠性。

    Solution containing a nitroxide radical for magnetometry by nuclear magnetic resonance
    3.
    发明授权
    Solution containing a nitroxide radical for magnetometry by nuclear magnetic resonance 失效
    含有核磁共振磁力计的氮氧自由基的溶液

    公开(公告)号：US5681753A

    公开(公告)日：1997-10-28

    申请号：US568757

    申请日：1995-12-07

    申请人： Carole Bourbon ,  Mehdi Moussavi

    发明人： Carole Bourbon ,  Mehdi Moussavi

    IPC分类号： C07B60/00 ,  G01R33/24 ,  G01N24/00 ,  G01V3/00

    CPC分类号： C07B61/02 ,  G01R33/24 ,  Y10T436/24

    摘要： The invention relates to a solution containing a nitroxide radical for magnetometry by nuclear magnetic resonance. This solution is constituted by a nitroxide radical of formula: ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which can be the same or different, represent an alkyl group or an alkoxy group which may be deuterated, or in which the pairs R.sup.1 -R.sup.2 and/or R.sup.3 -R.sup.4 together form an optionally deuterated cycloalkyl or polycycloalkyl group, and N represent .sup.14 N or .sup.15 N, dissolved in a solvent having an oxidizing power and an appropriate viscosity. The solvent can be constituted by a mixture of water and two compounds respectively playing the part of the oxidizing agent and viscosity modifying agent, e.g. water, ethylene glycol and NalO.sub.4, or can be solely constituted by a mixture of water and an oxidizing agent able to modify the viscosity, such as acetic acid.

    摘要翻译： 本发明涉及含有用于通过核磁共振进行磁力计的氮氧自由基的溶液。 该溶液由式（I）的氮氧自由基构成，其中可以相同或不同的R 1，R 2，R 3和R 4表示可以被氘化的烷基或烷氧基，或 其中对R1-R2和/或R3-R4一起形成任选的氘代环烷基或多环烷基，N代表14N或15N，溶解在具有氧化能力和适当粘度的溶剂中。 溶剂可以由水和两种化合物的混合物构成，分别在氧化剂和粘度调节剂的一部分中播放。 水，乙二醇和NalO 4，或者可以由水和能够改变粘度的氧化剂的混合物，例如乙酸构成。

    Process for preparing 2,2'-bis(halomethyl)-1,1'-binaphthyl
    4.
    发明授权
    Process for preparing 2,2'-bis(halomethyl)-1,1'-binaphthyl 失效
    制备2,2'-双（卤代甲基）-1,1'-联萘的方法

    公开(公告)号：US5502261A

    公开(公告)日：1996-03-26

    申请号：US408057

    申请日：1995-03-21

    申请人： Hans-Jerg Kleiner ,  Dieter Regnat ,  Horst Ro/ schert

    发明人： Hans-Jerg Kleiner ,  Dieter Regnat ,  Horst Ro/ schert

    IPC分类号： C07B61/00 ,  C07B60/00 ,  C07C17/14 ,  C07C25/22 ,  C07C22/04

    CPC分类号： C07C17/14

    摘要： The present invention relates to a process for preparing 2,2'-bis(halomethyl)-1,1'-binaphthyl, by reacting 2,2'-dimethyl-1,1'-binaphthyl in the presence of a solvent with a halogenating agent under the action of light having a wavelength of from 10.sup.-5 to 10.sup.-8 m in the presence or absence of a free-radical former at from -10.degree. to 120.degree. C.

    摘要翻译： 本发明涉及一种制备2,2'-双（卤代甲基）-1,1'-联萘的方法，通过在溶剂存在下使2,2'-二甲基-1,1'-联萘与卤化反应 在-10至120℃下，在存在或不存在自由基形成剂的情况下，在波长为10-5至10-8μm的光的作用下，

    Process for the preparation of N-oxyl hindered amine esters
    9.
    发明授权
    Process for the preparation of N-oxyl hindered amine esters 失效
    N-氧基受阻胺酯的制备方法

    公开(公告)号：US5574163A

    公开(公告)日：1996-11-12

    申请号：US298898

    申请日：1994-08-31

    申请人： John J. Luzzi

    发明人： John J. Luzzi

    IPC分类号： C07D211/44 ,  B01J31/02 ,  C07B60/00 ,  C07B61/00 ,  C07D211/94 ,  C07D211/46

    CPC分类号： C07B61/02 ,  C07D211/94

    摘要： When a tetraalkyl orthotitanate transesterification catalyst is used in the preparation of N-oxyl hindered amine esters, the N-oxyl compound is obtained in excellent yield and purity when moderate temperatures (90.degree.-130.degree. C.) and an aliphatic hydrocarbon solvent are used. The N-oxyl compounds are light stabilizers and also inhibitors for preventing the premature polymerization of ethylenically unsaturated monomers.

    摘要翻译： 当使用四烷基原钛酸酯酯交换催化剂制备N-氧基受阻胺酯时，在中等温度（90°-130℃）和使用脂族烃溶剂的情况下，获得了具有优异产率和纯度的N-氧基化合物 。 N-氧基化合物是光稳定剂，还有用于防止烯属不饱和单体过早聚合的抑制剂。