公开(公告)号：US20070129346A1

公开(公告)日：2007-06-07

申请号：US10579042

申请日：2004-11-12

Applicant: Koo Lee ,  Heui-Sul Park ,  In-Ae Ahn ,  Hyun-Ju Yoo ,  Jong-Yup Kim ,  Deog-Young Choi ,  Hyeon-Joo Yim ,  Kyung-Ha Chung ,  Dong-Sup Shim ,  Sang-Kyun Lee ,  Yutaka Kondoh ,  Ryoji Hirabayashi ,  Shugo Honda ,  Hidetaka Kaku ,  Jun-ichi Shishikura ,  Hiroyuki Ito ,  Takeshi Kurama

Inventor： Koo Lee ,  Heui-Sul Park ,  In-Ae Ahn ,  Hyun-Ju Yoo ,  Jong-Yup Kim ,  Deog-Young Choi ,  Hyeon-Joo Yim ,  Kyung-Ha Chung ,  Dong-Sup Shim ,  Sang-Kyun Lee ,  Yutaka Kondoh ,  Ryoji Hirabayashi ,  Shugo Honda ,  Hidetaka Kaku ,  Jun-ichi Shishikura ,  Hiroyuki Ito ,  Takeshi Kurama

IPC: A61K31/397 ,  A61K31/401 ,  A61K31/445 ,  C07D211/06

CPC classification number: C04B35/632 ,  C07D205/04 ,  C07D207/14 ,  C07D211/58 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12

Abstract: The present invention relates a compound of formula 1, and pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.

Abstract translation: 本发明涉及有效作为黑皮质素受体激动剂的式1化合物及其药学上可接受的盐，水合物，溶剂化物或异构体，以及包含与活性成分相同的黑皮质素受体激动剂组合物。

公开(公告)号：US07879852B2

公开(公告)日：2011-02-01

申请号：US12305935

申请日：2007-07-13

Applicant: Sung Pil Choi ,  In Ae Ahn ,  Sang Hyup Lee ,  Sang Dae Lee ,  Mi Sook Shin ,  Koo Lee ,  Deog Young Choi ,  Dong Sup Shim ,  Hyeon Joo Yim ,  Min Kyung Yoon ,  Soo Yong Chung ,  Jung Ae Lee ,  Yong Hwa Ha ,  Young Kwan Kim ,  Oeuk Park ,  Hyun Min Lee ,  Youn Hoa Kim

Inventor： Sung Pil Choi ,  In Ae Ahn ,  Sang Hyup Lee ,  Sang Dae Lee ,  Mi Sook Shin ,  Koo Lee ,  Deog Young Choi ,  Dong Sup Shim ,  Hyeon Joo Yim ,  Min Kyung Yoon ,  Soo Yong Chung ,  Jung Ae Lee ,  Yong Hwa Ha ,  Young Kwan Kim ,  Oeuk Park ,  Hyun Min Lee ,  Youn Hoa Kim

IPC: A61K31/401 ,  A61K31/4025 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/5377 ,  C07D207/14 ,  C07D213/72 ,  C07D263/48 ,  C07D277/54 ,  C07D295/28

CPC classification number: C07D207/16 ,  C07D207/48 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to a compound of the following formula 1, pharmaceutically acceptable salt and isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.

Abstract translation: 本发明涉及有效作为黑皮质素受体激动剂的下式1化合物，其药学上可接受的盐和异构体，以及包含与活性成分相同的黑皮质素受体激动剂组合物。

公开(公告)号：US07989634B2

公开(公告)日：2011-08-02

申请号：US10579042

申请日：2004-11-12

Applicant: Koo Lee ,  Heui-Sul Park ,  In-Ae Ahn ,  Hyun-Ju Yoo ,  Jong-Yup Kim ,  Deog-Young Choi ,  Hyeon-Joo Yim ,  Kyung-Ha Chung ,  Dong-Sup Shim ,  Sang-Kyun Lee ,  Yutaka Kondoh ,  Ryoji Hirabayashi ,  Shugo Honda ,  Hidetaka Kaku ,  Jun-ichi Shishikura ,  Hiroyuki Ito ,  Takeshi Kurama

Inventor： Koo Lee ,  Heui-Sul Park ,  In-Ae Ahn ,  Hyun-Ju Yoo ,  Jong-Yup Kim ,  Deog-Young Choi ,  Hyeon-Joo Yim ,  Kyung-Ha Chung ,  Dong-Sup Shim ,  Sang-Kyun Lee ,  Yutaka Kondoh ,  Ryoji Hirabayashi ,  Shugo Honda ,  Hidetaka Kaku ,  Jun-ichi Shishikura ,  Hiroyuki Ito ,  Takeshi Kurama

IPC: C07D213/46 ,  C07D211/70 ,  C07D401/00

CPC classification number: C04B35/632 ,  C07D205/04 ,  C07D207/14 ,  C07D211/58 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12

Abstract: The present invention relates a compound of formula 1, and pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.

Abstract translation: 本发明涉及有效作为黑皮质素受体激动剂的式1化合物及其药学上可接受的盐，水合物，溶剂化物或异构体，以及包含与活性成分相同的黑皮质素受体激动剂组合物。

公开(公告)号：US08470836B2

公开(公告)日：2013-06-25

申请号：US12747860

申请日：2008-12-19

Applicant: Chang-Seok Lee ,  Hyeon Joo Yim ,  Kyoung-Hee Kim ,  Jaeick Lee ,  Sung-Hack Lee ,  Kyu Woong Lee ,  Hee Bong Lee ,  Wan Su Park ,  Changhee Min

Inventor： Chang-Seok Lee ,  Hyeon Joo Yim ,  Kyoung-Hee Kim ,  Jaeick Lee ,  Sung-Hack Lee ,  Kyu Woong Lee ,  Hee Bong Lee ,  Wan Su Park ,  Changhee Min

IPC: A01N43/90 ,  A61K31/519 ,  C07D471/00 ,  C07D487/00

CPC classification number: C07D471/04

Abstract: Disclosed herein are novel compounds of Formula (1) as defined in the specification having excellent inhibitory activity against dipeptidyl peptidase-IV (DPP-IV), methods of preparing the same and pharmaceutical compositions comprising the same as an active agent.

Abstract translation: 本文公开的是具有对二肽基肽酶-IV（DPP-IV）具有优异抑制活性的本说明书中定义的新颖的式（1）化合物，其制备方法和包含其作为活性剂的药物组合物。

公开(公告)号：US20100274013A1

公开(公告)日：2010-10-28

申请号：US12747860

申请日：2008-12-19

Applicant: Chang-Seok Lee ,  Hyeon Joo Yim ,  Kyoung-Hee Kim ,  Jaeick Lee ,  Sung-Hack Lee ,  Kyu Woong Lee ,  Hee Bong Lee ,  Wan Su Park ,  Changhee Min

Inventor： Chang-Seok Lee ,  Hyeon Joo Yim ,  Kyoung-Hee Kim ,  Jaeick Lee ,  Sung-Hack Lee ,  Kyu Woong Lee ,  Hee Bong Lee ,  Wan Su Park ,  Changhee Min

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Disclosed herein are novel compounds of Formula (1) as defined in the specification having excellent inhibitory activity against dipeptidyl peptidase-IV (DPP-IV), methods of preparing the same and pharmaceutical compositions comprising the same as an active agent.

Abstract translation: 本文公开的是具有对二肽基肽酶-IV（DPP-IV）具有优异抑制活性的本说明书中定义的新颖的式（1）化合物，其制备方法和包含其作为活性剂的药物组合物。

公开(公告)号：US07879848B2

公开(公告)日：2011-02-01

申请号：US11910370

申请日：2006-03-30

Applicant: Chang-Seok Lee ,  Jong Sung Koh ,  Ki Dong Koo ,  Geun Tae Kim ,  Kyoung-Hee Kim ,  Sang Yong Hong ,  Sungsub Kim ,  Min-Jung Kim ,  Hyeon Joo Yim ,  Dongchul Lim ,  Hye Jin Kim ,  Hee Oon Han ,  Seong Cheol Bu ,  Oh Hwan Kwon ,  Sung Ho Kim ,  Gwong-Cheung Hur ,  Ji Young Kim ,  Zi-Ho Yeom ,  Dong-Jun Yeo

Inventor： Chang-Seok Lee ,  Jong Sung Koh ,  Ki Dong Koo ,  Geun Tae Kim ,  Kyoung-Hee Kim ,  Sang Yong Hong ,  Sungsub Kim ,  Min-Jung Kim ,  Hyeon Joo Yim ,  Dongchul Lim ,  Hye Jin Kim ,  Hee Oon Han ,  Seong Cheol Bu ,  Oh Hwan Kwon ,  Sung Ho Kim ,  Gwong-Cheung Hur ,  Ji Young Kim ,  Zi-Ho Yeom ,  Dong-Jun Yeo

IPC: C07D471/04 ,  C07D413/14 ,  A61K31/519 ,  A61K31/5355 ,  A61K31/4355 ,  A61P3/10 ,  A61K31/437 ,  A61K31/5025 ,  C07D487/04 ,  C07D217/14 ,  C07D498/04

CPC classification number: C07D487/04 ,  C07D401/06 ,  C07D413/06 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04

Abstract: Novel compounds exhibiting good inhibitory activity versus Dipeptidyl Peptidase-IV(DPP-IV) include those of the following formula (1) or pharmaceutically acceptable salt thereof: wherein A is a substituted or unsubstituted 1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridine, 5,6 -dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine, 4,5-dihydro-7H-isooxazolo[3,4-c]pyridine, 3,4 -dihydroisoquinoline, 5,8-dihydropyrido[3,4-d]pyrimidine, or 6,7 -dihydro[1,3]thiazolo[4,5,c]pyridine, and B is a substituted or unsubstituted piperidin-2-one, morpholin-3-one, oxazolidin-2-one, pyrrolidin-2-one, or 1,5-dihydro-pyrrol-2-one. Methods of preparing the novel inhibitory compounds of formula (1) and pharmaceutical compositions containing the same as an active agent are disclosed.

Abstract translation: 对二肽基肽酶-IV（DPP-IV）显示出良好抑制活性的新型化合物包括下式（1）或其药学上可接受的盐：其中A是取代或未取代的1,4,5,7-四氢 - 吡唑并[ 3,4-c]吡啶，5,6-二氢-8H- [1,2,4]三唑并[4,3-a]吡嗪，4,5-二氢-7H-异恶唑并[3,4-c]吡啶 ，3,4-二氢异喹啉，5,8-二氢吡啶并[3,4-d]嘧啶或6,7-二氢[1,3]噻唑并[4,5，c]吡啶，B是取代或未取代的哌啶 -2-酮，吗啉-3-酮，恶唑烷-2-酮，吡咯烷-2-酮或1,5-二氢 - 吡咯-2-酮。 公开了制备式（1）的新型抑制性化合物和含有它们作为活性剂的药物组合物的方法。

公开(公告)号：US20090298829A1

公开(公告)日：2009-12-03

申请号：US12305935

申请日：2007-07-13

Applicant: Sung Pil Choi ,  In Ae Ahn ,  Sang Hyup Lee ,  Sang Dae Lee ,  Mi Sook Shin ,  Koo Lee ,  Deog Young Choi ,  Dong Sup Shim ,  Hyeon Joo Yim ,  Min Kyung Yoon ,  Soo Yong Chung ,  Jung Ae Lee ,  Yong Hwa Ha ,  Young Kwan Kim ,  Oeuk Park ,  Hyun Min Lee ,  Youn Hoa Kim

Inventor： Sung Pil Choi ,  In Ae Ahn ,  Sang Hyup Lee ,  Sang Dae Lee ,  Mi Sook Shin ,  Koo Lee ,  Deog Young Choi ,  Dong Sup Shim ,  Hyeon Joo Yim ,  Min Kyung Yoon ,  Soo Yong Chung ,  Jung Ae Lee ,  Yong Hwa Ha ,  Young Kwan Kim ,  Oeuk Park ,  Hyun Min Lee ,  Youn Hoa Kim

IPC: A61K31/4025 ,  C07D401/06 ,  C07D413/14 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10 ,  A61P29/00 ,  A61P15/00

CPC classification number: C07D207/16 ,  C07D207/48 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to a compound of the following formula 1, pharmaceutically acceptable salt and isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.

Abstract translation: 本发明涉及有效作为黑皮质素受体激动剂的下式1化合物，其药学上可接受的盐和异构体，以及包含与活性成分相同的黑皮质素受体激动剂组合物。

公开(公告)号：US20080188471A1

公开(公告)日：2008-08-07

申请号：US11910370

申请日：2006-03-30

Applicant: Chang-Seok Lee ,  Jong Sung Koh ,  Ki Dong Koo ,  Geun Tae Kim ,  Kyoung-Hee Kim ,  Sang Yong Hong ,  Sungsub Kim ,  Min-Jung Kim ,  Hyeon Joo Yim ,  Dongchul Lim ,  Hye Jin Kim ,  Hee Oon Han ,  Seong Cheol Bu ,  Oh Hwan Kwon ,  Sung Ho Kim ,  Gwong-Cheung Hur ,  Ji Young Kim ,  Zi-Ho Yeom ,  Dong-Jun Yeo

Inventor： Chang-Seok Lee ,  Jong Sung Koh ,  Ki Dong Koo ,  Geun Tae Kim ,  Kyoung-Hee Kim ,  Sang Yong Hong ,  Sungsub Kim ,  Min-Jung Kim ,  Hyeon Joo Yim ,  Dongchul Lim ,  Hye Jin Kim ,  Hee Oon Han ,  Seong Cheol Bu ,  Oh Hwan Kwon ,  Sung Ho Kim ,  Gwong-Cheung Hur ,  Ji Young Kim ,  Zi-Ho Yeom ,  Dong-Jun Yeo

IPC: A61K31/4985 ,  A61P3/04 ,  A61P3/10 ,  C07D471/04 ,  A61K31/5355 ,  C07D487/04 ,  C07D413/02 ,  A61K31/519

CPC classification number: C07D487/04 ,  C07D401/06 ,  C07D413/06 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04

Abstract: The present invention relates to novel compounds exhibiting good inhibitory activity versus Dipeptidyl Peptidase-IV (DPP-IV), methods of preparing the same and pharmaceutical compositions containing the same as an active agent.

Abstract translation: 本发明涉及相对于二肽基肽酶-IV（DPP-IV）显示出良好抑制活性的新化合物，其制备方法和含有该活性剂的药物组合物。