公开(公告)号：US20100040660A1

公开(公告)日：2010-02-18

申请号：US12189951

申请日：2008-08-12

申请人： Moon Suk Kim ,  Hai Bang Lee ,  Ju Young Lee ,  Hyun Hee Ahn ,  Jung Hwa Lee ,  Kyung Sook Kim

发明人： Moon Suk Kim ,  Hai Bang Lee ,  Ju Young Lee ,  Hyun Hee Ahn ,  Jung Hwa Lee ,  Kyung Sook Kim

IPC分类号： A61K9/00 ,  C12N5/00 ,  A61K35/12 ,  A61P25/00

CPC分类号： C12N5/0622 ,  A61K35/12 ,  A61L27/3629 ,  A61L27/3834 ,  A61L27/3878 ,  A61L2400/06 ,  A61L2430/32 ,  C12N2533/40 ,  C12N2533/92

摘要： The present invention relates to a tissue-engineered scaffold prepared by using a biocompatible and injectable hydrogel, and particularly to a tissue-engineered scaffold capable of regenerating or recovering an injured spinal nerve for central nervous system after being implanted to connect neurons, prepared by combining an adult stem cell or a nerve cell with a physiologically active material on tissue-engineered carriers comprising biocompatible and temperature-sensitive polyethylene glycol/polyester block copolymer or biocompatible and injectable hydrogel made of small intestinal submucosa tissue powder with sol-gel phase transition behavior.

摘要翻译： 本发明涉及通过使用生物相容性和可注射的水凝胶制备的组织工程化支架，特别涉及能够在被植入以连接神经元之后再生或恢复用于中枢神经系统的受损脊髓神经的组织工程化支架，其通过组合 成体干细胞或在组织工程载体上具有生理活性物质的神经细胞，其包含由溶胶 - 凝胶相变行为的小肠粘膜下层组织粉末制成的生物相容性和温度敏感性聚乙二醇/聚酯嵌段共聚物或生物相容性和可注射的水凝胶。

公开(公告)号：US20090136461A1

公开(公告)日：2009-05-28

申请号：US12284117

申请日：2008-09-18

申请人： Moon Suk Kim ,  Hyun Hee Ahn ,  Jung Hwa Lee ,  Hee Jung Jung ,  Hai Bang Lee ,  Kyung Sook Kim ,  Ju Young Lee

发明人： Moon Suk Kim ,  Hyun Hee Ahn ,  Jung Hwa Lee ,  Hee Jung Jung ,  Hai Bang Lee ,  Kyung Sook Kim ,  Ju Young Lee

IPC分类号： A61K35/30 ,  C12N5/08 ,  A61P25/00

CPC分类号： C12N5/0618 ,  C12N2501/065 ,  C12N2506/1353 ,  C12N2506/1384

摘要： The present invention relates to a neuronal differentiation method of adult stem cells using small molecules, more particularly to a method for inducing differentiation of adult stem cells into nerve cells using small molecules, which enables effective differentiation into nerve cells and, thus, is useful in treating intractable CNS disorders such as Parkinson's disease, dementia, Alzheimer's disease and spinal cord injury.

摘要翻译： 本发明涉及使用小分子的成体干细胞的神经元分化方法，更具体地涉及使用小分子诱导成体干细胞分化为神经细胞的方法，其能够有效分化成神经细胞，因此可用于 治疗顽固性CNS疾病如帕金森病，痴呆，阿尔茨海默病和脊髓损伤。