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    PREPARATION AND CHARACTERIZATION OF POLYETHYLENEGLYCOL/POLYESTERS AS BIOCOMPATIBLE THERMO-SENSITIVE MATERIALS
    3.
    发明申请
    PREPARATION AND CHARACTERIZATION OF POLYETHYLENEGLYCOL/POLYESTERS AS BIOCOMPATIBLE THERMO-SENSITIVE MATERIALS 审中-公开
    聚乙烯醇/聚酯作为生物易受热敏材料的制备与表征

    公开(公告)号：US20070218099A1

    公开(公告)日：2007-09-20

    申请号：US11686168

    申请日：2007-03-14

    申请人： Moon Suk Kim ,  Hai Bang Lee ,  Hoon Hyun ,  Gilson Khang ,  Jung Won Lee

    发明人： Moon Suk Kim ,  Hai Bang Lee ,  Hoon Hyun ,  Gilson Khang ,  Jung Won Lee

    IPC分类号： A61F2/02 ,  C08F20/00

    CPC分类号： C08G63/664

    摘要： The present invention relates to a biocompatible and thermosensitive poly(ethylene glycol)/polyester block copolymer and a method of its preparation thereof, and particularly to a multi-functional intelligent hydrogel polymer comprising a hydrophilic part of a poly(ethylene glycol) (PEG) having a low molecular weight and a hydrophobic part comprising an ester-based caprolactone (CL) segment as an essential ingredient and further comprising a para-dioxanone (PDO) segment, a trimethylene carbonate (TMC) segment or a PDO/TMC copolymer containing the PDO and the TMC segments in a predetermined ratio, which easily forms a desired-shaped gel and decomposes or disperses without necessitating the operation process for removing the gel due to the temperature-dependent phase transition caused by the coagulation and the expansion of polymer micelles comprising a hydrophilic part and a hydrophobic part, thus being applicable to a drug delivery system or a porous support for tissue engineering purpose.

    摘要翻译： 本发明涉及一种生物相容性和热敏性聚（乙二醇）/聚酯嵌段共聚物及其制备方法，特别涉及包含聚（乙二醇）（PEG）的亲水部分的多功能智能水凝胶聚合物， 具有低分子量和疏水部分，其包含基于酯的己内酯（CL）链段作为必需成分，并且还包含对二恶烷酮（PDO）链段，三亚甲基碳酸酯（TMC）链段或PDO / TMC共聚物，其含有 PDO和TMC片段，其容易形成所需形状的凝胶并分解或分散，而不需要由于由凝结和聚合物胶束的膨胀引起的温度依赖性相变来除去凝胶的操作过程，所述凝胶和聚合物胶束包含 亲水部分和疏水部分，因此可用于组织工程用的药物递送系统或多孔载体 噢

    TEMPERATURE-SENSITIVE POLYETHYLENE GLYCOL / POLYESTER BLOCK COPOLYMER IN WHICH BIOACTIVE FUNCTIONAL GROUP IS INTRODUCED INTO SIDE CHAIN THEREOF
    5.
    发明申请
    TEMPERATURE-SENSITIVE POLYETHYLENE GLYCOL / POLYESTER BLOCK COPOLYMER IN WHICH BIOACTIVE FUNCTIONAL GROUP IS INTRODUCED INTO SIDE CHAIN THEREOF 有权
    生物活性官能团的温度敏感性聚乙烯甘油酯/聚酯嵌段共聚物被引入到其中

    公开(公告)号：US20130331526A1

    公开(公告)日：2013-12-12

    申请号：US13983905

    申请日：2011-11-22

    申请人： Moon Suk Kim ,  Jae Il Kim

    发明人： Moon Suk Kim ,  Jae Il Kim

    IPC分类号： A61K47/34

    CPC分类号： A61K47/34 ,  A61K9/0024 ,  A61K47/593 ,  A61K47/60 ,  A61L31/06 ,  A61L31/14 ,  A61L31/145 ,  A61L31/16 ,  C08G63/664 ,  C08G63/912 ,  C08G2261/126 ,  C08L71/02 ,  C08L2205/05 ,  C08L67/00 ,  C08L67/04

    摘要： The present invention relates to preparation and application of a temperature-sensitive polyethylene glycol/polyester block copolymer having a bioactive functional group introduced into a side chain thereof. More specifically, it relates to a temperature-sensitive polyethylene glycol/polyester block copolymer including a lactide segment having a bioactive functional group introduced into a side chain thereof and a method for preparing same. The temperature-sensitive polyethylene glycol/polyester block copolymer according to the present invention having a bioactive functional group introduced into a side chain thereof can be widely used as a drug delivery system, a support for tissue engineering, an adhesion inhibitor, etc.

    摘要翻译： 本发明涉及引入其侧链的具有生物活性官能团的温度敏感性聚乙二醇/聚酯嵌段共聚物的制备和应用。 更具体地说，本发明涉及包含引入其侧链的生物活性官能团的丙交酯链段的温度敏感性聚乙二醇/聚酯嵌段共聚物及其制备方法。 具有引入其侧链的生物活性官能团的本发明的温度敏感性聚乙二醇/聚酯嵌段共聚物可广泛用作药物递送系统，组织工程用支持体，粘着抑制剂等。

    DRUG DELIVERY FORMULATION FOR CONTROLLING OF INITIAL BURST AND MANUFACTURING METHOD THEREOF
    6.
    发明申请
    DRUG DELIVERY FORMULATION FOR CONTROLLING OF INITIAL BURST AND MANUFACTURING METHOD THEREOF 审中-公开
    用于控制初始爆炸物的药物输送配方及其制造方法

    公开(公告)号：US20120177740A1

    公开(公告)日：2012-07-12

    申请号：US13022734

    申请日：2011-02-08

    申请人： Moon Suk Kim ,  Da Yeon Kim

    发明人： Moon Suk Kim ,  Da Yeon Kim

    IPC分类号： A61K9/16 ,  A61K39/00 ,  A61K38/02 ,  A61P3/10 ,  A61P29/00 ,  A61P19/02 ,  A61P35/00 ,  A61P1/04 ,  A61K9/00 ,  A61P37/06

    CPC分类号： A61K9/10 ,  A61K9/0024 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5031 ,  A61K9/5089 ,  A61K38/00 ,  A61K47/34

    摘要： Provided is a drug delivery system for control of initial burst of a drug. More particularly, there are provided a drug delivery formulation including: a granule containing a biodegradable polymer and a drug; and a temperature-sensitive hydrogel, and a method for preparing the same. The presently disclosed drug delivery formulation can be prepared via a relatively simple process and allows a drug to be released slowly at a constant rate without initial burst and thus maintains a constant blood level of the drug for a long period of time. Consequently, it is capable of preventing the initial burst of the existing injection-type drug delivery formulations and slow-release granules and providing a desired release profile, including sustained release with time.

    摘要翻译： 提供了用于控制药物的初始爆发的药物递送系统。 更具体地，提供了药物递送制剂，其包含：含有可生物降解的聚合物和药物的颗粒; 和温度敏感性水凝胶及其制备方法。 目前公开的药物递送制剂可以通过相对简单的方法制备，并且允许药物以恒定速率缓慢释放而没有初始爆发，从而长期维持药物的恒定血液水平。 因此，其能够防止现有注射型药物递送制剂和缓释颗粒的初始爆发，并提供期望的释放特征，包括随时间的持续释放。

    Drug delivery formulation for controlling of initial burst and manufacturing method thereof
    8.
    发明授权
    Drug delivery formulation for controlling of initial burst and manufacturing method thereof 有权

    公开(公告)号：US10307373B2

    公开(公告)日：2019-06-04

    申请号：US13022734

    申请日：2011-02-08

    申请人： Moon Suk Kim ,  Da Yeon Kim

    发明人： Moon Suk Kim ,  Da Yeon Kim

    IPC分类号： A61K9/10 ,  A61K9/00 ,  A61K9/16 ,  A61K9/50 ,  A61K47/34 ,  A61K38/00

    摘要： Provided is a drug delivery system for control of initial burst of a drug. More particularly, there are provided a drug delivery formulation including: a granule containing a biodegradable polymer and a drug; and a temperature-sensitive hydrogel, and a method for preparing the same. The presently disclosed drug delivery formulation can be prepared via a relatively simple process and allows a drug to be released slowly at a constant rate without initial burst and thus maintains a constant blood level of the drug for a long period of time. Consequently, it is capable of preventing the initial burst of the existing injection-type drug delivery formulations and slow-release granules and providing a desired release profile, including sustained release with time.