公开(公告)号：US20100209349A1

公开(公告)日：2010-08-19

申请号：US12579242

申请日：2009-10-14

申请人： Yun-Jeong Heo ,  Yu-Rim Lee ,  Hyun-Hee Jung ,  You-Hee Cho

发明人： Yun-Jeong Heo ,  Yu-Rim Lee ,  Hyun-Hee Jung ,  You-Hee Cho

IPC分类号： A61K49/00 ,  C12N7/00 ,  A61K35/76 ,  A61P31/04

CPC分类号： C12Q1/18 ,  A61K35/76 ,  C12N2795/10232

摘要： This invention relates to a bacteriophage MPK6 (deposit number: KCCM 11044P) having a lytic activity to Pseudomonas aeruginosa, or a progeny bacteriophage thereof having a RFLP (Restriction fragment length polymorphism) DNA profile substantially equivalent to the bacteriophage MPK6. The present invention provides a bacteriophage MPK6 or a progeny bacteriophage thereof capable of treating a Pseudomonas aeruginosa infection disease, and suggests an anti-bacterial activity of MPK6 and its progeny bacteriophage using a mammalian and non-mammalian infection model. According to the present invention, the present bacteriophage MPK6 or progeny bacteriophage thereof represents very effective efficacy on treatment of P. aeruginosa-induced peritonitis-sepsis.

摘要翻译： 本发明涉及具有对绿脓假单胞菌具有裂解活性的噬菌体MPK6（保藏号：KCCM 11044P），或其具有与噬菌体MPK6基本相同的RFLP（限制性片段长度多态性）DNA图谱的后代噬菌体。 本发明提供能够治疗铜绿假单胞菌感染疾病的噬菌体MPK6或其后代噬菌体，并且使用哺乳动物和非哺乳动物感染模型提示MPK6及其后代噬菌体的​​抗细菌活性。 根据本发明，本发明的噬菌体MPK6或其后代噬菌体对治疗铜绿假单胞菌诱导的腹膜炎败血症具有非常有效的疗效。

公开(公告)号：US08282920B2

公开(公告)日：2012-10-09

申请号：US12579242

申请日：2009-10-14

申请人： Yun-Jeong Heo ,  Yu-Rim Lee ,  Hyun-Hee Jung ,  You-Hee Cho

发明人： Yun-Jeong Heo ,  Yu-Rim Lee ,  Hyun-Hee Jung ,  You-Hee Cho

IPC分类号： A01N63/00 ,  A61K39/40 ,  A61K39/00 ,  A61K45/00 ,  A61K39/108 ,  C12N15/00

CPC分类号： C12Q1/18 ,  A61K35/76 ,  C12N2795/10232

摘要： This invention relates to a bacteriophage MPK6 (deposit number: KCCM 11044P) having a lytic activity to Pseudomonas aeruginosa, or a progeny bacteriophage thereof having a RFLP (Restriction fragment length polymorphism) DNA profile substantially equivalent to the bacteriophage MPK6. The present invention provides a bacteriophage MPK6 or a progeny bacteriophage thereof capable of treating a Pseudomonas aeruginosa infection disease, and suggests an anti-bacterial activity of MPK6 and its progeny bacteriophage using a mammalian and non-mammalian infection model. According to the present invention, the present bacteriophage MPK6 or progeny bacteriophage thereof represents very effective efficacy on treatment of P. aeruginosa-induced peritonitis-sepsis.

摘要翻译： 本发明涉及具有对绿脓假单胞菌具有裂解活性的噬菌体MPK6（保藏号：KCCM 11044P），或其具有与噬菌体MPK6基本相同的RFLP（限制性片段长度多态性）DNA图谱的后代噬菌体。 本发明提供能够治疗铜绿假单胞菌感染疾病的噬菌体MPK6或其后代噬菌体，并且使用哺乳动物和非哺乳动物感染模型提示MPK6及其后代噬菌体的​​抗细菌活性。 根据本发明，本发明的噬菌体MPK6或其后代噬菌体对治疗铜绿假单胞菌诱导的腹膜炎败血症具有非常有效的疗效。