专利检索 ap:"ICM - INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE" 第 1 页

1.

发明授权
Method of diagnosis, prognostic or treatment of neurodegenerative disease 有权

公开(公告)号：US10324096B2

公开(公告)日：2019-06-18

申请号：US15196180

申请日：2016-06-29

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE PARIS-EST CRETEIL VAL DE MARNE , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , ICM - INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE , OTR3 , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS

发明人： Dulce Papy-Garcia , Minh Bao Huynh , Nadia Soussi-Yanicostas , Rita Vozari , Fernando Sineriz , Constantin Yanicostas

IPC分类号： G01N33/68 , C12Q1/68 , A61K31/70 , A61K31/737 , A61K31/713 , C12Q1/6886 , C12N15/113 , A61K31/727 , A61K38/17 , C12Q1/686 , G01N33/53 , A61K31/721 , C12Q1/6883 , C07H21/02

摘要： Methods for the diagnosis and prognosis of neurodegenerative diseases, such as Alzheimer's disease, are described. Compositions and method for the treatment of neurodegenerative diseases are also described.

2.

发明授权
Boosting Treg cells for treating Alzheimer disease and related disorders 有权

公开(公告)号：US10183061B2

公开(公告)日：2019-01-22

申请号：US14392315

申请日：2014-06-20

申请人： ICM (INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE) , APHP (ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE PIERRE ET MARIE CURIE-PARIS 6 (UPMC)

发明人： Guillaume Dorothee , Eliane Piaggio , Dylla Ait Ahmed , Pierre Aucouturier

IPC分类号： A61K38/20 , A61K45/06 , C07K14/55 , A61K39/00

摘要： The present invention relates to the boosting of Treg cells for the treatment of Alzheimer's disease and related disorders.

3.

发明授权
Pharmaceutical compositions for prevention or treatment of neurodegenerative diseases 有权

公开(公告)号：US10059748B2

公开(公告)日：2018-08-28

申请号：US15317196

申请日：2015-06-08

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ PAUL SABATIER TOULOUSE III , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6) , ICM (INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE)

发明人： Daniel Dunia , Marion Szelechowski , Alexandre Betourne , Stephane Hunot

IPC分类号： A61K38/00 , C07K14/005 , A61K38/16 , C12N7/00

CPC分类号： C07K14/005 , A61K38/162 , C07K2319/07 , C07K2319/10 , C12N7/00 , C12N2740/16322 , C12N2760/00022 , C12N2760/00033

摘要： The present invention relates to methods and compositions for the prevention or treatment of neurodegenerative diseases.

4.

发明申请
METHOD OF DIAGNOSIS, PROGNOSIS OR TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开

公开(公告)号：US20180045740A1

公开(公告)日：2018-02-15

申请号：US15684445

申请日：2017-08-23

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE PARIS-EST CRETEIL VAL DE MARNE , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , ICM - INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE , OTR3 , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS

发明人： Dulce PAPY-GARCIA , Minh Bao HUYNH , Nadia SOUSSI-YANICOSTAS , Rita VOZARI , Fernando SINERIZ , Constantin YANICOSTAS

IPC分类号： G01N33/68 , A61K31/721 , C12Q1/68 , C12N15/113 , A61K31/70 , G01N33/53 , A61K31/737 , A61K31/727 , A61K31/713 , A61K38/17

CPC分类号： G01N33/6896 , A61K31/70 , A61K31/713 , A61K31/721 , A61K31/727 , A61K31/737 , A61K38/1703 , A61K38/1709 , C12N15/1137 , C12N2310/14 , C12N2310/3233 , C12N2320/30 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Y208/02023 , C12Y208/02029 , G01N33/5308 , G01N2333/47 , G01N2333/91194 , G01N2440/14 , G01N2500/20 , G01N2800/28 , G01N2800/2821 , G01N2800/52

摘要： Methods for the diagnosis and prognosis of neurodegenerative diseases, such as a Tauopathy or Alzheimer's disease, are described. Compositions and methods for the treatment of neurodegenerative diseases are also described.

5.

发明申请
PHARMACEUTICAL COMPOSITIONS FOR PREVENTION OR TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开

公开(公告)号：US20170137472A1

公开(公告)日：2017-05-18

申请号：US15317196

申请日：2015-06-08

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET LA RECHERCHE MÉDICALE , UNIVERSITÉ PAUL SABATIER TOULOUSE III , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6) , ICM (INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE)

发明人： Daniel DUNIA , Marion SZELECHOWSKI , Alexandre BETOURNE , Stephane HUNOT

IPC分类号： C07K14/005 , C12N7/00 , A61K38/16

CPC分类号： C07K14/005 , A61K38/162 , C07K2319/07 , C07K2319/10 , C12N7/00 , C12N2740/16322 , C12N2760/00022 , C12N2760/00033

摘要： The present invention relates to methods and compositions for the prevention or treatment of neurodegenerative diseases.

6.

发明授权
Method for characterizing the physiological state of a patient from the analysis of the cerebral electrical activity of said patient, and monitoring device applying said method 有权

公开(公告)号：US10939838B2

公开(公告)日：2021-03-09

申请号：US14398217

申请日：2013-05-03

申请人： UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , FONDATION ICM—INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS

发明人： Thomas Similowski , Mathieu Raux , Mario Chavez , Jacques Martinerie , Pierre Pouget

IPC分类号： A61B5/04 , A61B5/048 , A61B5/00 , A61M16/00

摘要： The invention relates to a method for detecting a physiological state of a patient deviating from a reference physiological state, in which, after having determined, in each of Q frequency bands, R reference matrices PRq,r with qe[1 . . . Q] and rϵ[1 . . . R] which correspond to the reference physiological state, the following steps are repeated in a loop: carrying out measurements, in M time segments, of an electroencephalographic signal; filtering and centering the measurements in Q frequency bands to obtain and determine M×Q scaled matrices of spatial covariance; for each time segment m, calculating a deviation from the reference physiological state, and comparing each of the deviations from the reference physiological state to a predefined threshold. The invention also relates to a monitoring device applying said method.