公开(公告)号：US20180045740A1

公开(公告)日：2018-02-15

申请号：US15684445

申请日：2017-08-23

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE PARIS-EST CRETEIL VAL DE MARNE ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  ICM - INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE ,  OTR3 ,  ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS

发明人： Dulce PAPY-GARCIA ,  Minh Bao HUYNH ,  Nadia SOUSSI-YANICOSTAS ,  Rita VOZARI ,  Fernando SINERIZ ,  Constantin YANICOSTAS

IPC分类号： G01N33/68 ,  A61K31/721 ,  C12Q1/68 ,  C12N15/113 ,  A61K31/70 ,  G01N33/53 ,  A61K31/737 ,  A61K31/727 ,  A61K31/713 ,  A61K38/17

CPC分类号： G01N33/6896 ,  A61K31/70 ,  A61K31/713 ,  A61K31/721 ,  A61K31/727 ,  A61K31/737 ,  A61K38/1703 ,  A61K38/1709 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/3233 ,  C12N2320/30 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y208/02023 ,  C12Y208/02029 ,  G01N33/5308 ,  G01N2333/47 ,  G01N2333/91194 ,  G01N2440/14 ,  G01N2500/20 ,  G01N2800/28 ,  G01N2800/2821 ,  G01N2800/52

摘要： Methods for the diagnosis and prognosis of neurodegenerative diseases, such as a Tauopathy or Alzheimer's disease, are described. Compositions and methods for the treatment of neurodegenerative diseases are also described.

公开(公告)号：US11708593B2

公开(公告)日：2023-07-25

申请号：US17949489

申请日：2022-09-21

申请人： OPTIMVIA, LLC

发明人： Daniel H. Lajiness ,  Tarsis Gesteira Ferreira

IPC分类号： C12P19/26 ,  C12N9/10

CPC分类号： C12P19/26 ,  C12N9/13 ,  C12Y208/02023

摘要： The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors. Each of the engineered sulfotransferase enzymes have a biological activity characterized by the position within the heparosan-based polysaccharide that receives the sulfo group, including glucosaminyl N-sulfotransferase activity, hexuronyl 2-O sulfotransferase activity, glucosaminyl 6-O sulfotransferase activity, or glucosaminyl 3-O sulfotransferase activity. Methods of using the engineered sulfotransferases to produce sulfated heparosan-based polysaccharides, including polysaccharides having anticoagulant activity, are also provided.

公开(公告)号：US20160334421A1

公开(公告)日：2016-11-17

申请号：US15196180

申请日：2016-06-29

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE PARIS-EST CRETEIL VAL DE MARNE ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  ICM - INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE ,  OTR3 ,  ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS

发明人： Dulce PAPY-GARCIA ,  Minh Bao HUYNH ,  Nadia SOUSSI-YANICOSTAS ,  Rita VOZARI ,  Fernando SINERIZ ,  Constantin YANICOSTAS

IPC分类号： G01N33/68 ,  C12Q1/68 ,  A61K31/737 ,  C12N15/113 ,  A61K31/721

CPC分类号： G01N33/6896 ,  A61K31/70 ,  A61K31/713 ,  A61K31/721 ,  A61K31/727 ,  A61K31/737 ,  A61K38/1703 ,  A61K38/1709 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/3233 ,  C12N2320/30 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y208/02023 ,  C12Y208/02029 ,  G01N33/5308 ,  G01N2333/47 ,  G01N2333/91194 ,  G01N2440/14 ,  G01N2500/20 ,  G01N2800/28 ,  G01N2800/2821 ,  G01N2800/52

摘要： Methods for the diagnosis and prognosis of neurodegenerative diseases, such as Alzheimer's disease, are described. Compositions and method for the treatment of neurodegenerative diseases are also described.

摘要翻译： 描述了神经变性疾病如阿尔茨海默病的诊断和预后的方法。 还描述了治疗神经变性疾病的组合物和方法。

公开(公告)号：US20230340552A1

公开(公告)日：2023-10-26

申请号：US18135614

申请日：2023-04-17

申请人： OPTIMVIA, LLC

发明人： Tarsis Ferriera Gesteira ,  Daniel H. Lajiness

IPC分类号： C12P19/04 ,  A61K31/727 ,  C12N9/10 ,  C12N9/90 ,  C08B37/00 ,  C08J11/10

CPC分类号： C12P19/04 ,  A61K31/727 ,  C08B37/0003 ,  C08B37/0075 ,  C08J11/105 ,  C12N9/13 ,  C12N9/90 ,  C08J2305/10 ,  C12Y208/02008 ,  C12Y208/02023 ,  C12Y501/03017

摘要： The present invention includes methods for preparing anticoagulant polysaccharides using several non-naturally occurring, engineered sulfotransferase enzymes that are designed to react with aryl sulfate compounds instead of the natural substrate, PAPS, to facilitate sulfo group transfer to polysaccharide sulfo group acceptors. Suitable aryl sulfate compounds include, but are not limited to, p-nitrophenyl sulfate or 4-nitrocatechol sulfate. Anticoagulant polysaccharides produced by methods of the present invention comprise N—, 3—O—, 6-O-sulfated glucosamine residues and 2-O sulfated hexuronic acid residues, have comparable anticoagulant activity compared to commercially-available anticoagulant polysaccharides, and can be utilized to form truncated anticoagulant polysaccharides having a reduced molecular weight.

公开(公告)号：US20140302510A1

公开(公告)日：2014-10-09

申请号：US14351616

申请日：2012-10-15

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE PARIS-EST CRETEIL VAL DE MARNE ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  ICM-INSTITUT DU CERVEAU ET DE MOELLE EPINIERE ,  OTR3 ,  ASSISTANCE PUBLIQUE-HOPITAUX PARIS

发明人： Dulce Papy-Garcia ,  Minh Bao Huynh ,  Nadia Soussi-Yanicostas ,  Rita Vozari ,  Fernando Sineriz ,  Constantin Yanicostas

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： G01N33/6896 ,  A61K31/70 ,  A61K31/713 ,  A61K31/721 ,  A61K31/727 ,  A61K31/737 ,  A61K38/1703 ,  A61K38/1709 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/3233 ,  C12N2320/30 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y208/02023 ,  C12Y208/02029 ,  G01N33/5308 ,  G01N2333/47 ,  G01N2333/91194 ,  G01N2440/14 ,  G01N2500/20 ,  G01N2800/28 ,  G01N2800/2821 ,  G01N2800/52

摘要： The present invention relates to a method of diagnosis, prognostic or treatment of neurodegenerative diseases, in particular Alzheimer's disease.

摘要翻译： 本发明涉及诊断，预后或治疗神经变性疾病，特别是阿尔茨海默氏病的方法。