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公开(公告)号：US20100144035A1
公开(公告)日：2010-06-10
申请号：US12733061
申请日：2008-04-04
申请人： Yu-Kyoung Oh , Hyun-Gu Kang , Ji-Seok Kim , Jiang Ge , Ki-Su Kim , Ki-Tae Park , Su-Eun Han , Ga-Yong Shim , II-Hwan Cho , Sei-Kwang Hahn
发明人： Yu-Kyoung Oh , Hyun-Gu Kang , Ji-Seok Kim , Jiang Ge , Ki-Su Kim , Ki-Tae Park , Su-Eun Han , Ga-Yong Shim , II-Hwan Cho , Sei-Kwang Hahn
摘要： The present invention relates to a delivery system for nucleic acid using a cationic polymer conjugate, and more specifically relates to a delivery system for nucleic acid comprising a cationic polymer conjugate prepared by conjugating hyaluronic acid or its derivative and polyethyleneimine, and a composition of delivering a nucleic acid into mammalian cell comprising a complex of the nucleic acid and a cationic polymer conjugate with electrostatic binding.
摘要翻译： 本发明涉及使用阳离子聚合物缀合物的核酸递送系统，并且更具体地涉及用于核酸的递送系统，其包含通过将透明质酸或其衍生物和聚乙烯亚胺缀合而制备的阳离子聚合物缀合物，以及递送 核酸进入哺乳动物细胞，其包含核酸和具有静电结合的阳离子聚合物缀合物的复合物。
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2.发明申请Diary 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor 有权Diary 1,2,4-三唑衍生物作为高选择性环加氧酶-2抑制剂公开(公告)号：US20060009495A1
公开(公告)日：2006-01-12
申请号：US11224787
申请日：2005-09-12
申请人： II-hwan Cho , Jee-woong Lim , Ji-young Noh , Jong-hoon Kim , Sang-wook Park , Hyung-chul Ryu , Je-hak Kim , Jong-ho Kim , So-young Wang , Dal-hyun Kim , Chun-seon Lyu
发明人： II-hwan Cho , Jee-woong Lim , Ji-young Noh , Jong-hoon Kim , Sang-wook Park , Hyung-chul Ryu , Je-hak Kim , Jong-ho Kim , So-young Wang , Dal-hyun Kim , Chun-seon Lyu
IPC分类号： A61K31/4439 , C07D403/04
CPC分类号： C07D249/08 , C07D401/04
摘要： The present invention relates to a novel diaryl 1,2,4-triazole derivative of the following formula 1 as a highly selective cyclooxygenase-2 inhibitor: Wherein, R1, R2, R3, R4, R5, W and A is as defined in this specification.
摘要翻译： 本发明涉及作为高选择性环加氧酶-2抑制剂的新型的下式1的二芳基-1,2,4-三唑衍生物：其中R 1，R 2， R 3，R 4，R 5，W和A如本说明书中所定义。
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3.发明授权Nucleic acid delivery system comprising conjugates of PEI and hyaluronic acid 有权包含PEI和透明质酸的缀合物的核酸递送系统公开(公告)号：US08318856B2
公开(公告)日：2012-11-27
申请号：US12733061
申请日：2008-04-04
申请人： Yu-Kyoung Oh , Hyun-Gu Kang , Ji-Seok Kim , Jiang Ge , Ki-Su Kim , Ki-Tae Park , Su-Eun Han , Ga-Yong Shim , Ii-Hwan Cho , Sei-Kwang Hahn
发明人： Yu-Kyoung Oh , Hyun-Gu Kang , Ji-Seok Kim , Jiang Ge , Ki-Su Kim , Ki-Tae Park , Su-Eun Han , Ga-Yong Shim , Ii-Hwan Cho , Sei-Kwang Hahn
摘要： The present invention relates to a delivery system for nucleic acid using a cationic polymer conjugate, and more specifically relates to a delivery system for nucleic acid comprising a cationic polymer conjugate prepared by conjugating hyaluronic acid or its derivative and polyethyleneimine, and a composition of delivering a nucleic acid into mammalian cell comprising a complex of the nucleic acid and a cationic polymer conjugate with electrostatic binding.
摘要翻译： 本发明涉及使用阳离子聚合物缀合物的核酸递送系统，并且更具体地涉及用于核酸的递送系统，其包含通过将透明质酸或其衍生物和聚乙烯亚胺缀合而制备的阳离子聚合物缀合物，以及递送 核酸进入哺乳动物细胞，其包含核酸和具有静电结合的阳离子聚合物缀合物的复合物。
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4.发明授权3,4-dihydro-1H-naphthalene derivatives as a highly selective cyclooxygenase-2 inhibitor 失效3,4-二氢-1H-萘衍生物作为高选择性环加氧酶-2抑制剂公开(公告)号：US06768019B2
公开(公告)日：2004-07-27
申请号：US10456065
申请日：2003-06-05
申请人： Ii Hwan Cho , Jee Woong Lim , Ji Young Noh , Jong Hoon Kim , Sang Wook Park , Hyung Chul Ryu , Je Hak Kim , Hyung Ok Chun , So Young Wang , Sung Hak Lee
发明人： Ii Hwan Cho , Jee Woong Lim , Ji Young Noh , Jong Hoon Kim , Sang Wook Park , Hyung Chul Ryu , Je Hak Kim , Hyung Ok Chun , So Young Wang , Sung Hak Lee
IPC分类号： C07C25132
CPC分类号： C07D261/20 , C07C317/24 , C07C317/32 , C07C2602/10 , C07D231/54
摘要： The present invention relates to a novel 3,4-dihydro-1H-naphthalene derivative having a structure of formula 1 or formula 2, its pharmaceutically acceptable salts and their geometric isomers as a highly selective cyclooxygenase-2 inhibitor. Wherein R1, R2, X, A and Q are defined in this specification respectively.
摘要翻译： 本发明涉及具有式1或式2结构的新型3,4-二氢-1H-萘衍生物，其药学上可接受的盐及其几何异构体作为高度选择性的环氧合酶-2抑制剂。在R 1， R 2，X，A和Q分别在本说明书中定义。
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