公开(公告)号：US11696939B2

公开(公告)日：2023-07-11

申请号：US17138864

申请日：2020-12-30

申请人： ILIAS Biologics Inc ,  ILIAS Therapeutics, Inc.

发明人： Chulhee Choi ,  Kyungsun Choi ,  Ramkumar Menon

IPC分类号： A61K35/12 ,  A61K38/17 ,  A61K47/69 ,  A61P15/06 ,  A61K38/095 ,  A61K9/127 ,  A61K31/137 ,  A61K31/4025 ,  A61K31/405 ,  A61K31/43 ,  A61K31/4422 ,  A61K31/545 ,  A61K31/57 ,  A61K31/7048 ,  A61K33/06 ,  A61K38/16 ,  A61K38/45 ,  A61K38/51

CPC分类号： A61K38/1738 ,  A61K9/127 ,  A61K31/137 ,  A61K31/405 ,  A61K31/4025 ,  A61K31/43 ,  A61K31/4422 ,  A61K31/545 ,  A61K31/57 ,  A61K31/7048 ,  A61K33/06 ,  A61K38/095 ,  A61K38/164 ,  A61K38/168 ,  A61K38/1709 ,  A61K38/1774 ,  A61K38/45 ,  A61K38/51 ,  A61K47/6911 ,  A61P15/06

摘要： The present invention is related to compositions containing extracellular vesicles (exosomes) and methods of using the same for increasing lifespan of fetus, viability of fetus, or viability of newborn, for treating inflammation in uterus and/or fetus, for delaying preterm birth, or for treating a condition related to inflammation in uterus and/or fetus, wherein the extracellular vesicles comprising a nuclear factor kappa beta (NF-κB) inhibitor and a photo-specific binding protein.

公开(公告)号：US20240207360A1

公开(公告)日：2024-06-27

申请号：US18412403

申请日：2024-01-12

申请人： ILIAS BIOLOGICS INC. ,  ILIAS THERAPEUTICS, INC.

发明人： Chulhee CHOI ,  Nambin YIM ,  Hojun CHOI ,  Kyungsun CHOI ,  Seung-Wook RYU

IPC分类号： A61K38/17 ,  A61K38/00 ,  A61K47/69 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  C12N15/62 ,  C12N15/85 ,  C12P21/02

CPC分类号： A61K38/177 ,  A61K47/6917 ,  C07K14/705 ,  C07K14/70596 ,  C07K16/18 ,  C07K16/28 ,  C12N15/62 ,  C12N15/85 ,  C12P21/02 ,  A61K38/00 ,  C07K2317/80 ,  C07K2319/03 ,  C07K2319/70

摘要： The present invention provides a method for producing an exosome that transfers an active substance specifically to a target and the exosome produced by the same; a method for delivering the active substance to the target tissue using the exosome; a pharmaceutical composition for delivery of the active substance comprising the exosome as an active ingredient; and a composition for preparing the exosome comprising an expression vector wherein the target peptide is inserted into an extracellular portion of a transmembrane protein.

公开(公告)号：US20210275636A1

公开(公告)日：2021-09-09

申请号：US17138864

申请日：2020-12-30

申请人： ILIAS Biologics Inc ,  ILIAS Therapeutics, Inc. ,  Korea Advanced Institute of Science and Technology

发明人： Chulhee CHOI ,  Kyungsun CHOI ,  Ramkumar MENON

IPC分类号： A61K38/17 ,  A61K9/127 ,  A61K47/69 ,  A61K38/16 ,  A61K38/51 ,  A61K38/45 ,  A61K31/43 ,  A61K31/545 ,  A61K31/7048 ,  A61K31/57 ,  A61K31/405 ,  A61K33/06 ,  A61K31/137 ,  A61K31/4422 ,  A61K38/095 ,  A61K31/4025 ,  A61P15/06

摘要： The present invention is related to compositions containing extracellular vesicles (exosomes) and methods of using the same for increasing lifespan of fetus, viability of fetus, or viability of newborn, for treating inflammation in uterus and/or fetus, for delaying preterm birth, or for treating a condition related to inflammation in uterus and/or fetus, wherein the extracellular vesicles comprising a nuclear factor kappa beta (NF-κB) inhibitor and a photo-specific binding protein.

公开(公告)号：US20200206360A1

公开(公告)日：2020-07-02

申请号：US16639740

申请日：2018-08-16

申请人： ILIAS BIOLOGICS INC. ,  ILIAS THERAPEUTICS, INC.

发明人： Chulhee CHOI ,  Nambin YIM ,  Hojun CHOI ,  Kyungsun CHOI ,  Seung-Wook RYU

IPC分类号： A61K47/69 ,  C07K14/705 ,  C12N15/63

摘要： The present invention provides a method for producing an exosome that transfers an active substance specifically to a target and the exosome produced by the same; a method for delivering the active substance to the target tissue using the exosome; a pharmaceutical composition for delivery of the active substance comprising the exosome as an active ingredient; and a composition for preparing the exosome comprising an expression vector wherein the target peptide is inserted into an extracellular portion of a transmembrane protein.