公开(公告)号：US20180339035A1

公开(公告)日：2018-11-29

申请号：US16034209

申请日：2018-07-12

申请人： National University of Singapore ,  Institut Pasteur de Lille ,  Institut National de la Santé et de la Recherche Medicale (INSERM)

发明人： Sylvie Claudette Alonso ,  Rui Fen, Annabelle Lim ,  Camille Locht

IPC分类号： A61K39/02

CPC分类号： A61K39/099 ,  A61K2039/522

摘要： A CyaA-deficient B. pertussis mutant was constructed and used in a vaccine. The pertussis-specific antibody profile and Th17 response induced by vaccination with the mutant was surprisingly comparable to that induced by B. pertussis strains not deficient in CyaA.

公开(公告)号：US20230348934A1

公开(公告)日：2023-11-02

申请号：US18179269

申请日：2023-03-06

申请人： Ecole Normale Superieure De Lyon ,  Centre National de La Recherche Scientifique (CNRS) ,  Université Claude Bernard Lyon 1 ,  Institut National de la Santé et de la Recherche Medicale (INSERM)

发明人： Caroline COSTA FEJOZ ,  Els Verhoeyen ,  François-Loîc Cosset ,  Ruben Bender ,  Christian Buchholz ,  Qi Zhou

IPC分类号： C07K16/32 ,  C12N15/86 ,  C07K16/28 ,  A61P35/00 ,  C07K14/005 ,  C07K14/54

CPC分类号： C12N15/86 ,  A61P35/00 ,  C07K14/005 ,  C07K14/5418 ,  C07K16/2812 ,  C07K16/2815 ,  C07K16/32 ,  A61K2039/505 ,  C07K2319/03 ,  C07K2319/74 ,  C12N2740/16043 ,  C12N2740/16045 ,  C12N2760/18222 ,  C12N2760/18422

摘要： The present invention relates to pseudotyped retrovirus-like particles or retroviral vectors comprising both engineered envelope glycoproteins derived from a virus of the Paramyxoviridae family fused to a cell targeting domain and fused to a functional domain.
The present invention also relates to the use of said pseudotyped retrovirus-like particles or retroviral vectors to selectively modulate the activity of specific subsets of cells, in particular of specific immune cells. These pseudotyped retrovirus-like particles or retroviral vectors are particularly useful for gene therapy, immune therapy and/or vaccination.

公开(公告)号：US20220275420A1

公开(公告)日：2022-09-01

申请号：US17632094

申请日：2020-07-27

申请人： UNIVERSITÉ GRENOBLE ALPES ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE - INSERM ,  GRENOBLE INP (INSTITUT NATIONAL POLYTECHNIQUE) ,  CNRS - CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Abdelkader ZEBDA ,  Philippe CINQUIN ,  Donald MARTIN ,  Thomas SORANZO

IPC分类号： C12Q1/00 ,  C12Q1/26 ,  H01M4/86 ,  H01M4/90 ,  H01M8/16

摘要： A biomass-based enzymatic biocathode based on glucose, monosaccharide, ketone or aldehyde includes a collector conductor support, conductive particles disposed on and bound to said collector conductor support, and an aldose reductase disposed on said conductive particles, being bound thereto by adsorption and accessible at the surface of the monosaccharide, ketone or aldehyde reagent that is to be reduced when the biocathode is operational.

公开(公告)号：US20220362179A1

公开(公告)日：2022-11-17

申请号：US17642905

申请日：2020-10-23

申请人： SORBONNE UNIVERSITE ,  INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE (INSERM) ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

发明人： Jérémie GAUTHERON ,  Vlad RATZIU

IPC分类号： A61K31/165 ,  A61P1/16

摘要： The present invention relates to compounds and compositions comprising said compounds, for use in the prevention and/or treatment of non-alcoholic fatty liver disease (NAFLD), in particular hepatic steatosis or non-alcoholic steatohepatitis (NASH).