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1.发明公开公开(公告)号：US20240279612A1
公开(公告)日：2024-08-22
申请号：US18553316
申请日：2022-03-31
申请人： INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE , NANTES UNIVERSITÉ , HCS PHARMA , CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE) , CHU DE NANTES
IPC分类号： C12N5/071
CPC分类号： C12N5/0671 , C12N2500/02 , C12N2501/115 , C12N2501/12 , C12N2501/15 , C12N2501/155 , C12N2501/2306 , C12N2501/727 , C12N2501/999 , C12N2506/45 , C12N2513/00 , C12N2533/54 , C12N2537/10
摘要： The present disclosure relates to methods for preparing a liver organoid, as well as liver organoids obtained with the same and uses thereof. It was observed that, in presence of a set of suitable cell culture media, a use of a 3D porous scaffold and of alternated steps of hypoxic and normoxic conditions was able to drive the differentiation of stems cells in functional liver organoids comprising at least in hepatocytes, cholangiocytes, stellate cells, and sinusoidal endothelial cells. The obtained liver organoids expressed liver-specific genes, responded to LDL internalization, showed lipid accumulation and presented a strong activity of CYP enzymes.
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公开(公告)号：US20230256009A1
公开(公告)日：2023-08-17
申请号：US18303694
申请日：2023-04-20
申请人： TERALI INNOV SAS , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , INRA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE , CNRS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE STRASBOURG
IPC分类号： A61K33/00 , A61P25/00 , A61K31/522
CPC分类号： A61K33/00 , A61P25/00 , A61K31/522
摘要： The present invention relates to a novel pharmaceutical use of bromide, i.e. the treatment of autism spectral disorder (ASD).
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公开(公告)号：US11666599B2
公开(公告)日：2023-06-06
申请号：US16464403
申请日：2017-11-28
申请人： INSERM, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , INRA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE , CNRS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE STRASBOURG
IPC分类号： A61K33/00 , A61P25/00 , A61K31/522
CPC分类号： A61K33/00 , A61K31/522 , A61P25/00
摘要： The present invention relates to a novel pharmaceutical use of bromide, i.e. the treatment of autism spectral disorder (ASD).
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公开(公告)号：US20220275420A1
公开(公告)日：2022-09-01
申请号：US17632094
申请日：2020-07-27
申请人： UNIVERSITÉ GRENOBLE ALPES , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE - INSERM , GRENOBLE INP (INSTITUT NATIONAL POLYTECHNIQUE) , CNRS - CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
摘要： A biomass-based enzymatic biocathode based on glucose, monosaccharide, ketone or aldehyde includes a collector conductor support, conductive particles disposed on and bound to said collector conductor support, and an aldose reductase disposed on said conductive particles, being bound thereto by adsorption and accessible at the surface of the monosaccharide, ketone or aldehyde reagent that is to be reduced when the biocathode is operational.
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公开(公告)号：US20220011569A1
公开(公告)日：2022-01-13
申请号：US17296116
申请日：2019-11-20
申请人： UNIVERSITÉ GRENOBLE ALPES , GRENOBLE INP (INSTITUT POLYTECHNIQUE DE GRENOBLE) , CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE) , UNIVERSITÉ PARIS-SUD 11
发明人： Jocelyn MEYRON , Quentin MÉRIGOT , Boris THIBERT
摘要： Disclosed is a method for fabricating an optical component that is configured so as to generate on an illumination target in the near-field an illumination that has a determined pattern according to which each point (i) of the illumination target receives a quantity of light (alpha_i) via an illumination generated by an illumination light source that is incident on the optical component, which is placed between the illuminating light source and the illumination target.
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公开(公告)号：US20210106613A1
公开(公告)日：2021-04-15
申请号：US16464403
申请日：2017-11-28
申请人： INSERM, INSTITUE NATIONAL DE LA SANTE ET DE LA RESEARCHE MEDECALE , INRA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMOQIE , CNRS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE STRASBOURG
IPC分类号： A61K33/00 , A61K31/522 , A61P25/00
摘要： The present invention relates to a novel pharmaceutical use of bromide, i.e. the treatment of autism spectral disorder (ASD).
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公开(公告)号：US10465073B2
公开(公告)日：2019-11-05
申请号：US15036277
申请日：2014-11-14
发明人： Paolo Biagini , Riccardo Po' , Jean Roncali , Dora Demeter
摘要： An organic dye for a dye-sensitized solar cell (DSSC) comprising at least one electron-acceptor unit and at least one π-conjugated unit is described. Said organic dye is particularly useful in a dye-sensitized photoelectric transformation element which, in its turn, can be used in a dye-sensitized solar cell (DSSC).
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公开(公告)号：US09837607B2
公开(公告)日：2017-12-05
申请号：US14391994
申请日：2013-04-10
CPC分类号： H01L45/142 , G11C13/0002 , G11C13/0007 , G11C13/0014 , H01L45/04 , H01L45/1253 , H01L45/14 , H01L45/141 , H01L45/143 , H01L45/146 , H01L45/147
摘要： A material belonging to the family of centrosymmetric Mott insulators is used as an active material in a resistively switched memory for storing data. The material is placed between two electrical electrodes, by virtue of which an electric field of a preset value is applied in order to form, by way of an electron avalanche effect, an elementary information cell that has at least two logic states.
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9.发明申请公开(公告)号：US20170141471A1
公开(公告)日：2017-05-18
申请号：US15127579
申请日：2015-03-17
发明人： Yaakoub Taachouche , Mohamed Himdi
CPC分类号： H01Q9/0407 , H01Q1/288 , H01Q1/38 , H01Q1/48 , H01Q3/22 , H01Q5/50 , H01Q9/0435 , H01Q9/0442 , H01Q9/0457 , H01Q9/0464 , H01Q9/145
摘要： A Frequency-tunable and slot-fed planar antenna is proposed. The antenna includes resonant patch, a first dielectric layer, a ground plane having a first slot for each linear polarization, a second dielectric layer and a transmission line having, for each first slot, an end strand extending beneath the first slot. The antenna is frequency tunable for each linear polarization through at least one variable capacitance element. The matching of the antenna varies, for each linear polarization, as a function of a bias voltage applied to the variable capacitance element(s). The antenna includes, for each linear polarization, at least one second slot extending along the first slot. The end strand of the transmission line extends between the first slot and second slots. The at least one second slot creates an additional resonance.
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10.发明申请公开(公告)号：US20170139196A1
公开(公告)日：2017-05-18
申请号：US15300126
申请日：2015-03-23
发明人： Julien Roul , Marc Tramier , Jacques Pecreaux
IPC分类号： G02B21/36 , G02B21/00 , G02B21/26 , G05B19/042 , G02B21/16
CPC分类号： G02B21/365 , G01N21/6458 , G02B21/0044 , G02B21/0076 , G02B21/16 , G02B21/26 , G05B19/042 , G05B19/0421 , G05B19/41815 , G05B2219/33278 , Y02P90/08
摘要： A method is proposed for driving a plurality of functional modules included in a multi-wavelength microscopy imaging device. The device includes at least one first functional module and a second functional module, adapted respectively to performing a first function and a second function. The method includes at least one iteration of the acts of: sending a first driving signal to the second functional module when the first functional module has performed said first function; the second functional module triggers the function upon reception of the first driving signal; sending a second driving signal to the first functional module when the second functional module has performed said second function; the first functional module triggers said first function upon reception of the second driving signal.
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