公开(公告)号：US09334227B2

公开(公告)日：2016-05-10

申请号：US12084575

申请日：2006-11-08

申请人： Graham Ronald Eastham ,  Mark Waugh ,  Philip Ian Richards

发明人： Graham Ronald Eastham ,  Mark Waugh ,  Philip Ian Richards

IPC分类号： C07C51/14 ,  C07C67/38 ,  C07F7/08 ,  C07F9/28 ,  C07C67/31 ,  B01J31/24 ,  C07C51/09

CPC分类号： C07C67/31 ,  B01J31/2414 ,  C07C51/09 ,  C07C67/38 ,  C07C59/08 ,  C07C59/01 ,  C07C69/68 ,  C07C69/675 ,  C07C69/67

摘要： A process for the carbonylation of ethylenically unsaturated compounds including vinyl esters and a process for the production of 3-hydroxy propanoate esters or acids. The process comprises reacting said compound with carbon monoxide in the presence of a source of hydroxyl groups and of a catalyst system. The catalyst system is obtainable by combining: (a) a metal of Group 8, 9 or 10 or a compound thereof: and (b) a bidentate ligand of general formula (I): X1(X2)-Q2-A-R—B-Q1-X3(X4).

摘要翻译： 包括乙烯基酯的烯属不饱和化合物的羰基化方法和用于制备3-羟基丙酸酯或酸的方法。 该方法包括在羟基源和催化剂体系的存在下使所述化合物与一氧化碳反应。 催化剂体系可以通过以下方法获得：（a）第8,9或10族金属或其化合物：和（b）通式（I）的二齿配体：X1（X2）-Q2-AR-B- Q1-X3（X4）。

公开(公告)号：US06228660B1

公开(公告)日：2001-05-08

申请号：US08474192

申请日：1995-06-07

申请人： Keith May ,  Michael Evans Prior ,  Ian Richards

发明人： Keith May ,  Michael Evans Prior ,  Ian Richards

IPC分类号： G01N33533

CPC分类号： G01N33/54366 ,  G01N30/90 ,  G01N33/54386 ,  G01N33/548 ,  G01N33/549 ,  G01N33/558 ,  G01N33/58 ,  G01N33/689 ,  G01N33/76 ,  G01N2800/368 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/814 ,  Y10S436/817 ,  Y10S436/818 ,  Y10S436/906

摘要： An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with the exterior of the casing via a bibulous sample receiving member (506) which protrudes from the casing such that a liquid test sample can be applied to the receiving member and permeate therefrom to the porous carrier, the carrier containing in a first zone a labelled specific binding reagent is freely mobile within the porous carrier when in the moist state, and in a second zone spatially distinct from the first zone unlabelled specific binding reagent for the same analyte which unlabelled reagent is permanently immobilized on the carrier material and is therefore not mobile in the moist state, the two zones being arranged such that liquid sample applied to the porous carrier can permeate via the first zone into the second zone, and the device incorporating means, such as an aperture (508) in the casing, enabling the extent (if any) to which the labelled reagent becomes bound in the second zone to be observed. Preferably the device includes a removable cap for the protruding bibulous member.

摘要翻译： 可用于例如妊娠试验的分析测试装置包括由不透水的固体材料（例如塑料材料）构成的中空壳体（500），其包含干燥多孔载体（510），所述干燥多孔载体（510）经由壳体的外部经由 吸收样品接收构件（506），其从壳体突出，使得液体测试样品可以施加到接收构件并从其渗透到多孔载体上，在第一区域中包含标记的特异性结合剂的载体可在 多孔载体在处于潮湿状态时，在与第一区空间不同的第二区中，未标记的特异性结合试剂用于相同分析物，未标记的试剂永久地固定在载体材料上，因此在潮湿状态下不能移动， 被布置成使得施加到多孔载体的液体样品可以经由第一区域渗透到第二区域中 装置结合的装置，例如壳体中的孔（508），使得能够观察标记的试剂在第二区域中结合的程度（如果有的话）。 优选地，该装置包括用于突出的吸水构件的可移除盖。

公开(公告)号：US06187598B1

公开(公告)日：2001-02-13

申请号：US08487319

申请日：1995-06-07

申请人： Keith May ,  Michael Evans Prior ,  Ian Richards

发明人： Keith May ,  Michael Evans Prior ,  Ian Richards

IPC分类号： G01N33558

CPC分类号： G01N33/54366 ,  G01N30/90 ,  G01N33/54386 ,  G01N33/548 ,  G01N33/549 ,  G01N33/558 ,  G01N33/58 ,  G01N33/689 ,  G01N33/76 ,  G01N2800/368 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/814 ,  Y10S436/817 ,  Y10S436/818 ,  Y10S436/906

摘要： An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with the exterior of the casing via a bibulous sample receiving member (506) which protrudes from the casing such that a liquid test sample can be applied to the receiving member and permeate therefrom to the porous carrier, the carrier containing in a first zone a labelled specific binding reagent is freely mobile within the porous carrier when in the moist state, and in a second zone spatially distinct from the first zone unlabelled specific binding reagent for the same analyte which unlabelled reagent is permanently immobilised on the carrier material and is therefore not mobile in the moist state, the two zones being arranged such that liquid sample applied to the porous carrier can permeate via the first zone into the second zone, and the device incorporating means, such as an aperture (508) in the casing, enabling the extent (if any) to which the labelled reagent becomes bound in the second zone to be observed. Preferably the device includes a removable cap for the protruding bibulous member.

摘要翻译： 可用于例如妊娠试验的分析测试装置包括由不透水的固体材料（例如塑料材料）构成的中空壳体（500），其包含干燥多孔载体（510），所述干燥多孔载体（510）经由壳体的外部经由 吸收样品接收构件（506），其从壳体突出，使得液体测试样品可以施加到接收构件并从其渗透到多孔载体上，在第一区域中包含标记的特异性结合剂的载体可在 多孔载体在处于潮湿状态时，在与第一区空间不同的第二区中，未标记的特异性结合试剂用于相同分析物，未标记的试剂永久地固定在载体材料上，因此在潮湿状态下不能移动， 被布置成使得施加到多孔载体的液体样品可以经由第一区域渗透到第二区域中 装置结合的装置，例如壳体中的孔（508），使得能够观察标记的试剂在第二区域中结合的程度（如果有的话）。 优选地，该装置包括用于突出的吸水构件的可移除盖。

公开(公告)号：US5622871A

公开(公告)日：1997-04-22

申请号：US102313

申请日：1993-07-15

申请人： Keith May ,  Michael E. Prior ,  Ian Richards

发明人： Keith May ,  Michael E. Prior ,  Ian Richards

IPC分类号： G01N30/90 ,  G01N33/543 ,  G01N33/548 ,  G01N33/549 ,  G01N33/558 ,  G01N33/58 ,  G01N33/68 ,  G01N33/76 ,  G01N37/00

CPC分类号： G01N33/548 ,  G01N33/54386 ,  G01N33/549 ,  G01N33/558 ,  G01N33/58 ,  G01N33/689 ,  G01N33/76 ,  G01N2800/368 ,  G01N30/90 ,  Y10S435/962 ,  Y10S435/97 ,  Y10S435/971 ,  Y10S435/973 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/814 ,  Y10S436/817 ,  Y10S436/818

摘要： An analytical test device useful for example in pregnancy testing, includes a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with the exterior of the casing via a bibulous sample receiving member (506) which protrudes from the casing such that a liquid test sample can be applied to the receiving member and permeate therefrom to the porous carrier, the carrier containing in a first zone a labelled specific binding reagent is freely mobile within the porous carrier when in the moist state, and in a second zone spatially distinct from the first zone unlabelled specific binding reagent for the same analyte which unlabelled reagent is permanently immobilised on the carrier material and is therefore not mobile in the moist state, the two zones being arranged such that liquid sample applied to the porous carrier can permeate via the first zone into the second zone, and the device incorporating an aperture (508) in the casing, enabling the extent (if any) to which the labelled reagent becomes bound in the second zone to be observed. Preferably the device includes a removable cap for the protruding bibulous member.

摘要翻译： 例如在妊娠试验中有用的分析测试装置包括由不透水的固体材料（例如塑料材料）构成的中空壳体（500），其包含干燥的多孔载体（510），所述干燥的多孔载体（510）经由壳体的外部经由 吸收样品接收构件（506），其从壳体突出，使得液体测试样品可以施加到接收构件并从其渗透到多孔载体上，在第一区域中包含标记的特异性结合剂的载体可在 多孔载体在处于潮湿状态时，在与第一区空间不同的第二区中，未标记的特异性结合试剂用于相同分析物，未标记的试剂永久地固定在载体材料上，因此在潮湿状态下不能移动， 被布置成使得施加到多孔载体的液体样品能够经由第一区域渗入第二区域，并且d 在壳体中结合有孔（508）的装置，使得能够在待观察的第二区域中结合标记的试剂的程度（如果有的话）。 优选地，该装置包括用于突出的吸水构件的可移除盖。

公开(公告)号：US20120309613A1

公开(公告)日：2012-12-06

申请号：US13516176

申请日：2009-12-15

申请人： Graham Ronald Eastham ,  Philip Ian Richards

发明人： Graham Ronald Eastham ,  Philip Ian Richards

IPC分类号： B01J31/24

CPC分类号： B01J31/24 ,  B01J2231/321 ,  B01J2531/80 ,  B01J2531/82 ,  B01J2531/824 ,  C07C45/50 ,  C07C67/38 ,  C07C47/02 ,  C07C69/24

摘要： A method of increasing the TON of a catalyst system for the monocarbonylation of ethylenically unsaturated compounds using carbon monoxide in the presence of a co-reactant, other than water or a source thereof, having a mobile hydrogen atom is described. The catalyst system is obtainable by combining: (a) a metal of Group (8, 9) or (10) or a suitable compound thereof; (b) a ligand of general formula (I) wherein the groups X3 and X4 independently represent univalent radicals of up to 30 atoms or X3 and X4 together form a bivalent radical of up to 40 atoms and X5 has up to 400 atoms; Q1 represents phosphorus, arsenic or antimony; and c) optionally, a source of anions. The method includes the step of adding water or a source thereof to the catalyst system. The method is preferably carried out in the presence of an electropositive metal.

摘要翻译： 描述了在具有可移动氢原子的非水或其来源的共反应物存在下，使用一氧化碳增加烯属不饱和化合物的单羰基化催化剂体系的TON的方法。 催化剂体系可以通过以下方法获得：（a）组（8,9）或（10）的金属或其合适的化合物; （b）通式（I）的配体，其中基团X3和X4独立地表示至多30个原子的一价基团，或者X 3和X 4一起形成至多40个原子的二价基团，X 5具有多达400个原子; Q1代表磷，砷或锑; 和c）任选的阴离子源。 该方法包括将水或其源添加到催化剂体系中的步骤。 该方法优选在正电性金属存在下进行。

公开(公告)号：US06818455B2

公开(公告)日：2004-11-16

申请号：US09794061

申请日：2001-02-28

申请人： Keith May ,  Michael Evans Prior ,  Ian Richards

发明人： Keith May ,  Michael Evans Prior ,  Ian Richards

IPC分类号： G01N33558

CPC分类号： G01N33/54366 ,  G01N30/90 ,  G01N33/54386 ,  G01N33/548 ,  G01N33/549 ,  G01N33/558 ,  G01N33/58 ,  G01N33/689 ,  G01N33/76 ,  G01N2800/368 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/814 ,  Y10S436/817 ,  Y10S436/818 ,  Y10S436/906

摘要： An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as; plastics materials, containing a dry porous carrier (510) which communicates indirectly with the exterior of the casing via a bibulous sample receiving member (506) which protrudes from the casing such that a liquid test sample can be applied to the receiving member and permeate therefrom to the porous carrier, the carrier containing in a first zone a labelled specific binding reagent is freely mobile within the porous carrier when in the moist state, and in a second zone spatially distinct from the first zone unlabelled specific binding reagent for the same analyte which unlabelled reagent is permanently immobilised on the carrier material and is therefore not mobile in the moist state, the two zones being arranged such that liquid sample applied to the porous carrier can permeate via the first zone into the second zone, and the device incorporating means, such as an aperture (508) in the casing, enabling the extent (if any) to which the labelled reagent becomes bound in the second zone to be observed. Preferably the device includes a removable cap for the protruding bibulous member.

摘要翻译： 例如在妊娠试验中有用的分析测试装置包括由不透水的固体材料构成的中空壳体（500） 塑料材料，其包含干燥的多孔载体（510），所述干燥的多孔载体（510）经由从壳体突出的吸水样品接收构件（506）间接地与壳体的外部连通，使得可以将液体测试样品施加到接收构件并从其渗透 在多孔载体中，当处于潮湿状态时，在第一区域中含有标记的特异性结合试剂的载体在多孔载体内可自由移动，并且在空间上不同于第一区域的第二区域未标记的特异性结合试剂用于相同的分析物， 未标记的试剂永久地固定在载体材料上，因此在潮湿状态下不能移动，这两个区域被布置成使得施加到多孔载体的液体样品可以经由第一区域渗入第二区域，并且装置结合装置， 例如壳体中的孔（508），使得标记的试剂在第二个zo中能够结合的程度（如果有的话） 待观察。 优选地，该装置包括用于突出的吸水构件的可移除盖。

公开(公告)号：US5602040A

公开(公告)日：1997-02-11

申请号：US241675

申请日：1994-05-12

申请人： Keith May ,  Michael E. Prior ,  Ian Richards

发明人： Keith May ,  Michael E. Prior ,  Ian Richards

IPC分类号： G01N33/53 ,  G01N30/90 ,  G01N33/543 ,  G01N33/548 ,  G01N33/549 ,  G01N33/558 ,  G01N33/58 ,  G01N33/68 ,  G01N33/76 ,  G01N37/00

CPC分类号： G01N33/54366 ,  G01N33/54386 ,  G01N33/548 ,  G01N33/549 ,  G01N33/558 ,  G01N33/58 ,  G01N33/689 ,  G01N33/76 ,  G01N2800/368 ,  G01N30/90 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/814 ,  Y10S436/817 ,  Y10S436/818 ,  Y10S436/906

摘要： An analytical test device useful for example in pregnancy testing, includes a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with the exterior of the casing via a bibulous sample receiving member (506) which protrudes from the casing such that a liquid test sample can be applied to the receiving member and permeate therefrom to the porous carrier, the carrier containing in a first zone a labelled specific binding reagent is freely mobile within the porous carrier when in the moist state, wherein the mobility is facilitated by a material comprising sugar, in a amount effective to reduce interaction between the test strip and the labelled reagent, and in a second zone spatially distinct from the first zone unlabeled specific binding reagent for the same analyte which unlabelled reagent is permanently immobilized on the carrier material and is therefore not mobile in the moist state, the two zones being arranged such that liquid sample applied to the porous carrier can permeate via the first zone into the second zone, and the device incorporating an aperture (508) in the casing, enabling the extent (if any) to which the labelled reagent becomes bound in the second zone to be observed. Preferably the device includes a removable cap for the protruding bibulous member.

摘要翻译： 例如在妊娠试验中有用的分析测试装置包括由不透水的固体材料（例如塑料材料）构成的中空壳体（500），其包含干燥的多孔载体（510），所述干燥的多孔载体（510）经由壳体的外部经由 吸收样品接收构件（506），其从壳体突出，使得液体测试样品可以施加到接收构件并从其渗透到多孔载体上，在第一区域中包含标记的特异性结合剂的载体在 当处于潮湿状态时，其中迁移率由包含糖的材料促进，其量可以有效地减少测试条与标记的试剂之间的相互作用，并且在空间上不同于第一区未标记的特异性结合试剂 对于相同的分析物，未标记的试剂永久固定在载体材料上，因此不可移动 两个区域被布置成使得施加到多孔载体上的液体样品能够经由第一区域渗透到第二区域中，并且在壳体中结合有孔（508）的装置能够实现（如果有的话） 标记的试剂在第二区域中被结合以被观察。 优选地，该装置包括用于突出的吸水构件的可移除盖。

公开(公告)号：US07109042B2

公开(公告)日：2006-09-19

申请号：US09780351

申请日：2001-02-12

申请人： Keith May ,  Michael Evans Prior ,  Ian Richards

发明人： Keith May ,  Michael Evans Prior ,  Ian Richards

IPC分类号： G01N33/558

CPC分类号： G01N33/54366 ,  G01N30/90 ,  G01N33/54386 ,  G01N33/548 ,  G01N33/549 ,  G01N33/558 ,  G01N33/58 ,  G01N33/689 ,  G01N33/76 ,  G01N2800/368 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/814 ,  Y10S436/817 ,  Y10S436/818 ,  Y10S436/906

摘要： An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with the exterior of the casing via a bibulous sample receiving member (506) which protrudes from the casing such that a liquid test sample can be applied to the receiving member and permeate therefrom to the porous carrier, the carrier containing in a first zone a labelled specific binding reagent is freely mobile within the porous carrier when in the moist state, and in a second zone spatially distinct from the first zone unlabelled specific binding reagent for the same analyte which unlabelled reagent is permanently immobilised on the carrier material and is therefore not mobile in the moist state, the two zones being arranged such that liquid sample applied to the porous carrier can permeate via the first zone into the second zone, and the device incorporating means, such as an aperture (508) in the casing, enabling the extent (if any) to which the labelled reagent becomes bound in the second zone to be observed. Preferably the device includes a removable cap for the protruding bibulous member.

摘要翻译： 可用于例如妊娠试验的分析测试装置包括由不透水的固体材料（例如塑料材料）构成的中空壳体（500），其包含干燥多孔载体（510），所述干燥多孔载体（510）经由壳体的外部经由 吸收样品接收构件（506），其从壳体突出，使得液体测试样品可以施加到接收构件并从其渗透到多孔载体上，在第一区域中包含标记的特异性结合剂的载体可在 多孔载体在处于潮湿状态时，在与第一区空间不同的第二区中，未标记的特异性结合试剂用于相同分析物，未标记的试剂永久地固定在载体材料上，因此在潮湿状态下不能移动， 被布置成使得施加到多孔载体的液体样品可以经由第一区域渗透到第二区域中 装置结合的装置，例如壳体中的孔（508），使得能够观察标记的试剂在第二区域中结合的程度（如果有的话）。 优选地，该装置包括用于突出的吸水构件的可移除盖。

公开(公告)号：US20050244986A1

公开(公告)日：2005-11-03

申请号：US10990946

申请日：2004-11-16

申请人： Keith May ,  Michael Prior ,  Ian Richards

发明人： Keith May ,  Michael Prior ,  Ian Richards

IPC分类号： G01N33/53 ,  G01N30/90 ,  G01N33/543 ,  G01N33/548 ,  G01N33/549 ,  G01N33/558 ,  G01N33/58 ,  G01N33/68 ,  G01N33/76 ,  G01N37/00

CPC分类号： G01N33/54366 ,  G01N30/90 ,  G01N33/54386 ,  G01N33/548 ,  G01N33/549 ,  G01N33/558 ,  G01N33/58 ,  G01N33/689 ,  G01N33/76 ,  G01N2800/368 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/814 ,  Y10S436/817 ,  Y10S436/818 ,  Y10S436/906

摘要： An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with the exterior of the casing via a bibulous sample receiving member (506) which protrudes from the casing such that a liquid test sample can be applied to the receiving member and permeate therefrom to the porous carrier, the carrier containing in a first zone a labelled specific binding reagent is freely mobile within the porous carrier when in the moist state, and in a second zone spatially distinct from the first zone unlabelled specific binding reagent for the same analyte which unlabelled reagent is permanently immobilised on the carrier material and is therefore not mobile in the moist state, the two zones being arranged such that liquid sample applied to the porous carrier can permeate via the first zone into the second zone, and the device incorporating means, such as an aperture (508) in the casing, enabling the extent (if any) to which the labelled reagent becomes bound in the second zone to be observed. Preferably the device includes a removable cap for the protruding bibulous member.

摘要翻译： 可用于例如妊娠试验的分析测试装置包括由不透水的固体材料（例如塑料材料）构成的中空壳体（500），其包含干燥多孔载体（510），所述干燥多孔载体（510）经由壳体的外部经由 吸收样品接收构件（506），其从壳体突出，使得液体测试样品可以施加到接收构件并从其渗透到多孔载体上，在第一区域中包含标记的特异性结合剂的载体可在 多孔载体在处于潮湿状态时，在与第一区空间不同的第二区中，未标记的特异性结合试剂用于相同分析物，未标记的试剂永久地固定在载体材料上，因此在潮湿状态下不能移动， 被布置成使得施加到多孔载体的液体样品可以经由第一区域渗透到第二区域中 装置结合的装置，例如壳体中的孔（508），使得能够观察标记的试剂在第二区域中结合的程度（如果有的话）。 优选地，该装置包括用于突出的吸水构件的可移除盖。

公开(公告)号：US20090163724A1

公开(公告)日：2009-06-25

申请号：US12084575

申请日：2006-11-08

申请人： Graham Ronald Eastham ,  Mark Waugh ,  Philip Ian Richards

发明人： Graham Ronald Eastham ,  Mark Waugh ,  Philip Ian Richards

IPC分类号： C07C67/38 ,  C07C51/14 ,  C07F9/28 ,  C07F7/08

CPC分类号： C07C67/31 ,  B01J31/2414 ,  C07C51/09 ,  C07C67/38 ,  C07C59/08 ,  C07C59/01 ,  C07C69/68 ,  C07C69/675 ,  C07C69/67

摘要： A process for the carbonylation of ethylenically unsaturated compounds including vinyl esters and a process for the production of 3-hydroxy propanoate esters or acids. The process comprises reacting said compound with carbon monoxide in the presence of a source of hydroxyl groups and of a catalyst system. The catalyst system is obtainable by combining: (a) a metal of Group 8, 9 or 10 or a compound thereof: and (b) a bidentate ligand of general formula (I): X1(X2)-Q2-A-R—B-Q1-X3(X4).

摘要翻译： 包括乙烯基酯的烯属不饱和化合物的羰基化方法和用于制备3-羟基丙酸酯或酸的方法。 该方法包括在羟基源和催化剂体系存在下使所述化合物与一氧化碳反应。 催化剂体系可以通过以下方式获得：（a）第8,9或10族金属或其化合物：和（b）通式（I）的二齿配体：X1（X2）-Q2-ARB-Q1- X3（X4）。