Solid dosage form comprising solid dispersion
    1.
    发明授权
    Solid dosage form comprising solid dispersion 有权
    包含固体分散体的固体剂型

    公开(公告)号:US08343548B2

    公开(公告)日:2013-01-01

    申请号:US11888529

    申请日:2007-08-01

    IPC分类号: A61K9/14 A61K9/50

    摘要: Provided are a solid dosage form comprising an enteric solid dispersion that allows a drug in the preparation to be rapidly dissolved without compromising the solubility of the solid dispersion, and a method for producing the same. More specifically, provided is a solid dosage form comprising an enteric solid dispersion comprising a poorly soluble drug, an enteric polymer and a disintegrant, wherein the disintegrant is low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m2/g. Moreover, provided is a method for producing a solid dosage form comprising an enteric solid dispersion, the method comprising steps of: spraying an enteric polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a powder of low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m2/g and serving as a disintegrant; and granulating the resultant; and drying.

    摘要翻译: 提供了一种固体剂型,其包含允许制剂中的药物快速溶解而不损害固体分散体的溶解性的肠溶固体分散体及其制备方法。 更具体地,提供了包含包含难溶性药物,肠溶性聚合物和崩解剂的肠溶性固体分散体的固体剂型,其中所述崩解剂是平均粒径为10〜100μm的低取代羟丙基纤维素,比表面积 通过BET法测量为至少1.0m 2 / g。 此外,提供了一种生产包含肠溶固体分散体的固体剂型的方法,所述方法包括以下步骤:将难溶性药物已经分散或溶解的肠溶性聚合物溶液喷雾到具有 平均粒径为10〜100μm,BET法测定的比表面积为1.0m 2 / g以上,作为崩解剂; 并造成结果; 并干燥。

    ORGANIC FIELD EFFECT TRANSISTOR AND ITS PRODUCTION METHOD
    2.
    发明申请
    ORGANIC FIELD EFFECT TRANSISTOR AND ITS PRODUCTION METHOD 有权
    有机场效应晶体及其生产方法

    公开(公告)号:US20100051927A1

    公开(公告)日:2010-03-04

    申请号:US12551205

    申请日:2009-08-31

    IPC分类号: H01L51/30 H01L51/40

    摘要: An organic field effect transistor (OFET) having a structure of a conductor layer/an insulator layer/a semiconductor layer is provided. This OFET comprises an insulator layer formed by mixing a polymer compound produced by polymerizing or copolymerizing a monomer represented by the formula (1): CH2═CHCOO—(CH2)2—CN   (1) and/or a monomer represented by the formula (2): CH2═C(CH3)COO—(CH2)2—CN   (2) with a polymerizable and/or crosslinkable organic compound other than the monomer represented by the formula (1) or (2); and a semiconductor layer comprising an organic compound.

    摘要翻译: 提供具有导体层/绝缘体层/半导体层的结构的有机场效应晶体管(OFET)。 该OFET包括通过将由式(1)表示的单体:CH2 = CHCOO-(CH2)2-CN(1)表示的单体和/或由式(1)表示的单体 2):CH 2 = C(CH 3)COO-(CH 2)2 -CN(2)与除式(1)或(2)表示的单体之外的可聚合和/或可交联的有机化合物; 以及包含有机化合物的半导体层。

    Thin-layer chemical transistor and making method
    3.
    发明申请
    Thin-layer chemical transistor and making method 有权
    薄层化学晶体管及制作方法

    公开(公告)号:US20060043432A1

    公开(公告)日:2006-03-02

    申请号:US11199152

    申请日:2005-08-09

    IPC分类号: H01L23/58

    摘要: In a thin-layer chemical transistor having a metal/solid electrolyte/semiconductor structure, the materials of which the solid electrolyte and semiconductor layers are made comprise organic solvent-soluble compounds. The transistor can be fabricated solely by solvent processes, typically printing techniques including ink jet printing.

    摘要翻译: 在具有金属/固体电解质/半导体结构的薄层化学晶体管中,制备固体电解质和半导体层的材料包括有机溶剂可溶性化合物。 晶体管可以仅通过溶剂工艺制造,通常是印刷技术,包括喷墨印刷。

    Enteric coated granule and method for preparing the same
    4.
    发明授权
    Enteric coated granule and method for preparing the same 有权
    肠溶包衣颗粒及其制备方法

    公开(公告)号:US09095513B2

    公开(公告)日:2015-08-04

    申请号:US11764084

    申请日:2007-06-15

    IPC分类号: A61K9/16 A61K9/50

    摘要: The present invention is an enteric coated granule having controlled dissolution in water even at a small coating amount; and a preparation method thereof. More specifically, provided are an enteric coated granule comprising a raw granule or a granule comprising a raw granule and at least one layer covering the raw granule, a first enteric layer covering the raw granule or the granule, and a second enteric layer formed over the first enteric layer, wherein the first and the second enteric layers comprise a first and a second hydroxypropylmethyl cellulose acetate succinates (HPMCASs) different in solubility pH, respectively, and the solubility pH value of the second HPMCAS of the second enteric layer is lower than that of the first enteric layer; and a preparation method comprising steps of covering a raw granule or a granule comprising a raw granule and at least one layer covering the raw granule with an enteric coating agent comprising a first HPMCAS to form a first enteric layer; and forming, over the first enteric layer, a second coating layer by using a second enteric coating agent comprising a second HPMCAS having a lower solubility pH value than that of the first HPMCAS.

    摘要翻译: 本发明是即使以小的涂布量控制溶解在水中的肠溶衣颗粒剂; 及其制备方法。 更具体地,提供一种肠溶包衣颗粒,其包含原料颗粒或颗粒,其包含原料颗粒和覆盖原料颗粒的至少一层,覆盖原料颗粒或颗粒的第一肠溶层和形成在该颗粒上的第二肠溶层 第一肠溶层,其中第一和第二肠溶层分别包含溶解度pH不同的第一和第二羟丙基甲基纤维素乙酸琥珀酸酯(HPMCAS),第二肠溶层的第二HPMCAS的溶解度pH值低于第二肠溶层的溶解度pH值 的第一肠溶层; 以及包括以下步骤的方法,其包括用包含原料颗粒的原料颗粒或包含原料颗粒的至少一层的颗粒与包含第一HPMCAS的肠溶包衣剂一起覆盖以形成第一肠溶层; 并且通过使用包含比第一HPMCAS具有更低的溶解度pH值的第二HPMCAS的第二肠溶包衣剂,在第一肠溶层上形成第二涂层。

    Binder for Separator of Non-Aqueous Electrolyte Battery Comprising 2-Cyanoethyl Group-Containing Polymer and Separator and Battery Using the Same
    7.
    发明申请
    Binder for Separator of Non-Aqueous Electrolyte Battery Comprising 2-Cyanoethyl Group-Containing Polymer and Separator and Battery Using the Same 有权
    包含含2-氰基乙基的聚合物和分离器和使用其的电池的非水电解质电池分离器的粘合剂

    公开(公告)号:US20120258349A1

    公开(公告)日:2012-10-11

    申请号:US13430812

    申请日:2012-03-27

    IPC分类号: H01M2/16 C08F8/30

    摘要: An object of the invention is to provide a binder for a separator which can be comprised by a non-aqueous electrolyte battery with improved heat resistance, a separator comprising the binder, and a non-aqueous electrolyte battery comprising the separator. More specifically, provided are a binder for a separator of a non-aqueous electrolyte battery comprising at least a 2-cyanoethyl group-containing polymer having a molecular weight distribution (Mw/Mn), which is a ratio of a weight-average molecular weight (Mw) to a number-average molecular weight (Mn), of 6 or less, the weight-average molecular weight (Mw) of 50,000 to 1,000,000, and 30% by weight or less of a low molecular weight portion having a molecular weight of 30,000 or less.

    摘要翻译: 本发明的目的是提供一种用于隔板的粘合剂,其可以由耐热性改善的非水电解质电池组成,包含粘结剂的隔膜和包含隔膜的非水电解质电池组成。 更具体地说,提供一种非水电解质电池用隔膜的粘合剂,其包含至少含有2-氰基乙基的聚合物,其分子量分布(Mw / Mn)为重均分子量 (Mw)至数均分子量(Mn)为6以下,重均分子量(Mw)为50,000〜1,000,000,以及30重量%以下的具有分子量的低分子量部分 30,000或更少。

    Thin-filmed field effect transistor and making method
    8.
    发明授权
    Thin-filmed field effect transistor and making method 有权
    薄膜场效应晶体管及制作方法

    公开(公告)号:US08088642B2

    公开(公告)日:2012-01-03

    申请号:US12350715

    申请日:2009-01-08

    申请人: Ikuo Fukui

    发明人: Ikuo Fukui

    IPC分类号: H01L51/40

    摘要: In a thin-film field effect transistor with a MIS structure, the materials of which the semiconductor and insulating layers are made are polymers which are dissolvable in organic solvents and have a weight average molecular weight of more than 2,000 to 1,000,000. Use of polymers for both the semiconductor layer and insulating layer of TFT eliminates such treatments as patterning and etching using photoresists in the prior art circuit-forming technology, reduces the probability of TFT defects and achieves a reduction of TFT manufacture cost.

    摘要翻译: 在具有MIS结构的薄膜场效应晶体管中,制造半导体和绝缘层的材料是可溶于有机溶剂并且重均分子量大于2,000至1,000,000的聚合物。 在TFT的半导体层和绝缘层两者中使用聚合物消除了在现有技术的电路形成技术中使用光致抗蚀剂进行图案化和蚀刻的处理,降低了TFT缺陷的可能性并且实现了TFT制造成本的降低。

    Field effect transistor and making method
    9.
    发明授权
    Field effect transistor and making method 有权
    场效应晶体管及制作方法

    公开(公告)号:US07557392B2

    公开(公告)日:2009-07-07

    申请号:US11199152

    申请日:2005-08-09

    IPC分类号: H01L35/24 H01L51/00

    摘要: In a thin-layer chemical transistor having a metal/solid electrolyte/semiconductor structure, the materials of which the solid electrolyte and semiconductor layers are made comprise organic solvent-soluble compounds. The transistor can be fabricated solely by solvent processes, typically printing techniques including ink jet printing.

    摘要翻译: 在具有金属/固体电解质/半导体结构的薄层化学晶体管中,制备固体电解质和半导体层的材料包括有机溶剂可溶性化合物。 晶体管可以仅通过溶剂工艺制造,通常是印刷技术,包括喷墨印刷。

    THIN-FILMED FIELD EFFECT TRANSISTOR AND MAKING METHOD
    10.
    发明申请
    THIN-FILMED FIELD EFFECT TRANSISTOR AND MAKING METHOD 有权
    薄膜场效应晶体管和制作方法

    公开(公告)号:US20090124051A1

    公开(公告)日:2009-05-14

    申请号:US12350715

    申请日:2009-01-08

    申请人: Ikuo FUKUI

    发明人: Ikuo FUKUI

    IPC分类号: H01L21/288

    摘要: In a thin-film field effect transistor with a MIS structure, the materials of which the semiconductor and insulating layers are made are polymers which are dissolvable in organic solvents and have a weight average molecular weight of more than 2,000 to 1,000,000. Use of polymers for both the semiconductor layer and insulating layer of TFT eliminates such treatments as patterning and etching using photoresists in the prior art circuit-forming technology, reduces the probability of TFT defects and achieves a reduction of TFT manufacture cost.

    摘要翻译: 在具有MIS结构的薄膜场效应晶体管中,制造半导体和绝缘层的材料是可溶于有机溶剂并且重均分子量大于2,000至1,000,000的聚合物。 在TFT的半导体层和绝缘层两者中使用聚合物消除了在现有技术的电路形成技术中使用光致抗蚀剂进行图案化和蚀刻的处理,降低了TFT缺陷的可能性并且实现了TFT制造成本的降低。