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![Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof](/abs-image/US/2010/06/01/US07728165B2/abs.jpg.150x150.jpg)
1.发明授权Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof 失效制备（1R，2S，5S）-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸盐或其盐的方法和中间体公开(公告)号：US07728165B2
公开(公告)日：2010-06-01
申请号：US12484461
申请日：2009-06-15
申请人： Jeonghan Park , Anantha R Sudhakar , George S. K. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-long Kwok , Ingyu Jeon , Ramani R Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
发明人： Jeonghan Park , Anantha R Sudhakar , George S. K. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-long Kwok , Ingyu Jeon , Ramani R Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
IPC分类号： C07C69/01 , C07C211/17 , C07C235/02
CPC分类号： C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要： In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
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![Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof](/abs-image/US/2009/08/04/US07569705B2/abs.jpg.150x150.jpg)
2.发明授权Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof 失效其制备用于其盐的（1R，2S，5S）-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸盐的方法和中间体公开(公告)号：US07569705B2
公开(公告)日：2009-08-04
申请号：US11982875
申请日：2007-11-06
申请人： Jeonghan Park , Anantha R Sudhakar , George S. K. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-long Kwok , Ingyu Jeon , Ramani R Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
发明人： Jeonghan Park , Anantha R Sudhakar , George S. K. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-long Kwok , Ingyu Jeon , Ramani R Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
IPC分类号： C07D209/52
CPC分类号： C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要： In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
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![PROCESS AND INTERMEDIATES FOR THE PREPARATION OF (1R,2S,5S)-6,6-DIMETHYL-3-AZABICYCLO[3,1,0]HEXANE-2-CARBOXYLATES OR SALTS THEREOF](/abs-image/US/2009/10/01/US20090247784A1/abs.jpg.150x150.jpg)
3.发明申请PROCESS AND INTERMEDIATES FOR THE PREPARATION OF (1R,2S,5S)-6,6-DIMETHYL-3-AZABICYCLO[3,1,0]HEXANE-2-CARBOXYLATES OR SALTS THEREOF 失效（1R，2S，5S）-6,6-二甲基-3-亚氨基] [3,1,0]庚烷-2-羧酸酯或其盐的制备方法和中间体公开(公告)号：US20090247784A1
公开(公告)日：2009-10-01
申请号：US12484461
申请日：2009-06-15
申请人： Jeonghan Park , Anantha R. Sudhakar , George S. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani R. Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
发明人： Jeonghan Park , Anantha R. Sudhakar , George S. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani R. Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
IPC分类号： C07C61/04 , C07C229/38
CPC分类号： C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要： In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
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![Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof](/abs-image/US/2007/12/18/US07309717B2/abs.jpg.150x150.jpg)
4.发明授权Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof 有权制备（1R，2S，5S）-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸盐或其盐的方法和中间体公开(公告)号：US07309717B2
公开(公告)日：2007-12-18
申请号：US10867602
申请日：2004-06-15
申请人： Jeonghan Park , Anantha Sudhakar , George S. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani R. Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
发明人： Jeonghan Park , Anantha Sudhakar , George S. Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani R. Raghavan , Maria Tamarez , Weidong Tong , Eugene J. Vater
IPC分类号： A61K31/21 , C07D209/52
CPC分类号： C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要： In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
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![Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof](/abs-image/US/2008/05/15/US20080114179A1/abs.jpg.150x150.jpg)
5.发明申请Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof 失效其制备用于其盐的（1R，2S，5S）-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸盐的方法和中间体公开(公告)号：US20080114179A1
公开(公告)日：2008-05-15
申请号：US11982875
申请日：2007-11-06
申请人： Jeonghan Park , Anantha Sudhakar , George Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw Kwok , Ingyu Jeon , Ramani Raghavan , Maria Tamarez , Weidong Tong , Eugene Vater
发明人： Jeonghan Park , Anantha Sudhakar , George Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw Kwok , Ingyu Jeon , Ramani Raghavan , Maria Tamarez , Weidong Tong , Eugene Vater
IPC分类号： C07C211/33 , C07C69/74 , C07C63/08 , C07D209/44
CPC分类号： C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要： In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
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![Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof](/abs-image/US/2005/03/17/US20050059648A1/abs.jpg.150x150.jpg)
6.发明申请Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof 有权制备（1R，2S，5S）-6,6-二甲基-3-氮杂双环[3,1,0]己烷-2-羧酸盐或其盐的方法和中间体公开(公告)号：US20050059648A1
公开(公告)日：2005-03-17
申请号：US10867602
申请日：2004-06-15
申请人： Jeonghan Park , Anantha Sudhakar , George Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani Raghavan , Maria Tamarez , Weidong Tong , Eugene Vater
发明人： Jeonghan Park , Anantha Sudhakar , George Wong , Minzhang Chen , Juergen Weber , Xiaojing Yang , Daw-Jong Kwok , Ingyu Jeon , Ramani Raghavan , Maria Tamarez , Weidong Tong , Eugene Vater
IPC分类号： C07C69/74 , C07C215/20 , C07C233/58 , C07C271/18 , C07D209/52 , A61K31/33
CPC分类号： C07C233/58 , C07B2200/07 , C07C69/74 , C07C215/20 , C07C271/18 , C07C2601/02 , C07D209/52
摘要： In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物和在制备式I化合物的方法中制备的某些中间体化合物的方法。
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7.发明授权Synthesis of (4-bromophenyl)(4-piperidyl)methanone-(Z)-O-ethyloxime and salts 失效（4-溴苯基）（4-哌啶基）甲酮 - （Z）-O-乙基肟和盐的合成公开(公告)号：US07524963B2
公开(公告)日：2009-04-28
申请号：US11098642
申请日：2005-04-04
IPC分类号： C07D211/08 , C07D211/18 , C07D211/20
CPC分类号： C07D211/28
摘要： In one embodiment, the present invention describes the synthesis of (4-bromophenyl) (4-piperidyl)methanone-(Z)-O-ethyloxime and its acid salts, and similar compounds, in high stereochemical purity.
摘要翻译： 在一个实施方案中，本发明描述了具有高立体化学纯度的（4-溴苯基）（4-哌啶基）甲酮 - （Z）-O-乙基肟及其酸盐和类似化合物的合成。
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![Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl](/abs-image/US/2008/02/05/US07326795B2/abs.jpg.150x150.jpg)
8.发明授权Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl 失效制备（1R，2S，5S）-3-氮杂双环[3,1,0]己烷-2-甲酰胺，N- [3-氨基-1-（环丁基甲基）-2,3-二氧代丙基] -3 - [（2S）-2 - [[[1,1-二甲基乙基]氨基]羰基氨基] -3,3-二甲基-1-氧代丁基] -6,6-二甲基公开(公告)号：US07326795B2
公开(公告)日：2008-02-05
申请号：US10867600
申请日：2004-06-15
申请人： Anantha Sudhakar , Vilas Dahanukar , Ilia A. Zavialov , Cecilia Orr , Hoa N. Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael D. Green , George S. Wong , Jeonghan Park , Tetsuo Iwama
发明人： Anantha Sudhakar , Vilas Dahanukar , Ilia A. Zavialov , Cecilia Orr , Hoa N. Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael D. Green , George S. Wong , Jeonghan Park , Tetsuo Iwama
IPC分类号： C07D209/52 , C07C233/08
CPC分类号： C07K5/0202 , C07C271/22 , C07C2601/04
摘要： In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物的方法以及在制备式I化合物的方法中制备的某些中间体化合物。
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![Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl](/abs-image/US/2005/03/17/US20050059800A1/abs.jpg.150x150.jpg)
9.发明申请Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl 失效制备（1R，2S，5S）-3-氮杂双环[3,1,0]己烷-2-甲酰胺，N- [3-氨基-1-（环丁基甲基）-2,3-二氧代丙基] -3 - [（2S）-2 - [[[1,1-二甲基乙基]氨基]羰基氨基] -3,3-二甲基-1-氧代丁基] -6,6-二甲基公开(公告)号：US20050059800A1
公开(公告)日：2005-03-17
申请号：US10867600
申请日：2004-06-15
申请人： Anantha Sudhakar , Vilas Dahanukar , Ilia Zavialov , Cecilia Orr , Hoa Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael Green , George Wong , Jeonghan Park , Tetsuo Iwama
发明人： Anantha Sudhakar , Vilas Dahanukar , Ilia Zavialov , Cecilia Orr , Hoa Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael Green , George Wong , Jeonghan Park , Tetsuo Iwama
IPC分类号： C07C271/22 , C07K5/02 , C07K5/06
CPC分类号： C07K5/0202 , C07C271/22 , C07C2601/04
摘要： In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译： 在一个实施方案中，本申请涉及制备式I化合物的方法以及在制备式I化合物的方法中制备的某些中间体化合物。
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公开(公告)号：US20090326244A1
公开(公告)日：2009-12-31
申请号：US12518736
申请日：2007-12-13
IPC分类号： C07D209/52
CPC分类号： C07D209/52
摘要： A process for purifying the alpha-keto amide is (1R,5S)—N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]-amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide via a bisulfite adduct is disclosed.
摘要翻译： 纯化α-酮酰胺的方法是（1R，5S）-N- [3-氨基-1-（环丁基甲基）-2,3-二氧代丙基] -3- [2（S） - [[ 1,1-二甲基乙基）氨基]羰基] - 氨基] -3,3-二甲基-1-氧代丁基] -6,6-二甲基-3-氮杂双环[3.1.0]己-2（S） - 甲酰胺通过亚硫酸氢盐加合物 披露
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