公开(公告)号：US06458940B2

公开(公告)日：2002-10-01

申请号：US08887497

申请日：1997-07-02

Applicant: Peter C. Roberts ,  Bruce L. Frank ,  David E. Szymkowski ,  John S. Mills ,  John Goodchild ,  Jia L. Wolfe ,  Robert E. Kilkuskie ,  Isobel M. Greenfield ,  Veronica Sullivan

Inventor： Peter C. Roberts ,  Bruce L. Frank ,  David E. Szymkowski ,  John S. Mills ,  John Goodchild ,  Jia L. Wolfe ,  Robert E. Kilkuskie ,  Isobel M. Greenfield ,  Veronica Sullivan

IPC: C07H2102

CPC classification number: C12N15/1131 ,  A61K38/00 ,  C07H21/00 ,  C12N2310/3125 ,  C12N2310/314 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/334 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2310/3521

Abstract: The present invention discloses synthetic oligonucleotides complementary to a nucleic acid spanning the translational start site of human papillomavirus gene E1, and including at least 15 nucleotides. Also disclosed are methods and kits for inhibiting the replication of HPV, for inhibiting the expression of HPV nucleic acid and protein, for detection of HPV, and for treating HPV infections.

Abstract translation: 本发明公开了与跨越人乳头状瘤病毒基因E1的翻译起始位点的核酸互补的包含至少15个核苷酸的合成寡核苷酸。 还公开了用于抑制HPV的复制，用于抑制HPV核酸和蛋白质的表达，用于HPV检测和用于治疗HPV感染的方法和试剂盒。

公开(公告)号：US06509149B2

公开(公告)日：2003-01-21

申请号：US08471974

申请日：1995-06-06

Applicant: Peter C. Roberts ,  Bruce L. Frank ,  David E. Szymkowski ,  John S. Mills ,  John Goodchild ,  Jia L. Wolfe ,  Robert E. Kilkuskie ,  Isobel M. Greenfield ,  Veronica Sullivan

Inventor： Peter C. Roberts ,  Bruce L. Frank ,  David E. Szymkowski ,  John S. Mills ,  John Goodchild ,  Jia L. Wolfe ,  Robert E. Kilkuskie ,  Isobel M. Greenfield ,  Veronica Sullivan

IPC: C12Q170

CPC classification number: C12N15/1131 ,  A61K38/00 ,  C12N2310/321 ,  C12N2310/334 ,  C12N2310/351 ,  C12N2310/3521

Abstract: The present invention discloses synthetic oligonucleotides complementary to a nucleic acid spanning the translational start site of human papillomavirus gene E1, and including at least 15 nucleotides. Also disclosed are methods and kits for inhibiting the replication of HPV, for inhibiting the expression of HPV nucleic acid and protein, for detection of HPV, and for treating HPV infections.