公开(公告)号：US5844237A

公开(公告)日：1998-12-01

申请号：US791346

申请日：1997-01-31

申请人： Craig M. Whitehouse ,  J. Fred Banks, Jr. ,  Clement Catalano

发明人： Craig M. Whitehouse ,  J. Fred Banks, Jr. ,  Clement Catalano

IPC分类号： G01N27/62 ,  G01N30/72 ,  H01J49/04 ,  H01J49/10 ,  H01J49/26 ,  B01D59/44 ,  H01J49/00

CPC分类号： G01N30/7266 ,  H01J49/067 ,  H01J49/165 ,  G01N30/7293

摘要： Improvements have been made to the Electrospray and Atmospheric Pressure Chemical Ionization source chambers interfaced to mass spectrometers to simplify source performance optimization and source operation and to improve system sensitivity. The atmospheric pressure ion source procedure for optimizing performance has been simplified by adding windows along the sides of the atmospheric pressure ionization chamber allowing direct viewing of the Electrospray and Atmospheric pressure ion sources during operation. A cylindrical lens which extends along the side walls of the atmospheric pressure chamber has been configured to be semitransparent for viewing into the chamber. This cylindrical shaped side lens is electrically isolated from the Electrospray liquid introduction needle and Electrospray chamber endplate. Improved Electrospray mass spectrometer system sensitivity can be achieved when operating the cylindrical lens with a higher potential difference between it and the Electrospray liquid introduction needle than is set between the needle and the endplate.

公开(公告)号：US06060705A

公开(公告)日：2000-05-09

申请号：US988491

申请日：1997-12-10

申请人： Craig M. Whitehouse ,  J. Fred Banks, Jr. ,  Clement Catalano

发明人： Craig M. Whitehouse ,  J. Fred Banks, Jr. ,  Clement Catalano

IPC分类号： H01J49/42 ,  B01D59/44 ,  H01J49/00

CPC分类号： H01J49/165

摘要： Improvements have been made to the Electrospray and Atmospheric Pressure Chemical Ionization source chambers interfaced to mass spectrometers to simplify source performance optimization and source operation and to improve system sensitivity. The atmospheric pressure ion source procedure for optimizing performance has been simplified by adding windows along the sides of the atmospheric pressure ionization chamber allowing direct viewing of the Electrospray and Atmospheric pressure ion sources during operation. A cylindrical lens which extends along the side walls of the atmospheric pressure chamber has been configured to be semitransparent for viewing into the chamber. This cylindrical shaped side lens is electrically isolated from the Electrospray liquid introduction needle and Electrospray chamber endplate. Improved Electrospray mass spectrometer system sensitivity can be achieved when operating the cylindrical lens with a higher potential difference between it and the Electrospray liquid introduction needle than is set between the needle and the endplate.

摘要翻译： 已经对与质谱仪连接的电喷雾和大气压化学电离源室进行了改进，以简化源性能优化和源操作，并提高系统灵敏度。 通过在大气压电离室的侧面添加窗口可简化用于优化性能的大气压离子源程序，从而可以在运行期间直接观察电喷雾和大气压离子源。 沿着大气压力室的侧壁延伸的圆柱形透镜已经被配置为半透明的，用于观察室。 该圆柱形侧透镜与电喷雾液引入针和电喷雾室终板电隔离。 当操作具有比电针与终板之间设置的电喷雾引入针之间更高的电位差的柱面透镜时，可以实现改进的电喷雾质谱系统灵敏度。