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公开(公告)号:US12106952B2
公开(公告)日:2024-10-01
申请号:US17057731
申请日:2019-05-31
Applicant: Micromass UK Limited
Inventor: Alastair Booth , Alvin Chua , Carl Chen , Marcus Dawber , Pham Hoang Vu Ngo , William Ngo , Dennis Ong , Richard Tyldesley-Worster , Arvind Rangan , Steven Rocha
CPC classification number: H01J49/068 , H01J49/067
Abstract: A lens assembly for an outer source of a mass spectrometer, the assembly comprising: a housing; a plurality of lens elements, each lens element comprising a radially extending electrically conductive protrusion, the lens elements being linearly arranged in the housing such that the protrusions are aligned with one another; and an interface connector having a plurality of sockets to receive the protrusions therein and create an electrical connection between the protrusions and sockets. A housing for a resistance temperature detector is also disclosed.
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公开(公告)号:US12027357B2
公开(公告)日:2024-07-02
申请号:US17622568
申请日:2020-07-22
Applicant: DH Technologies Development PTE. LTD.
Inventor: Bruce Collings , Pascal Martin
CPC classification number: H01J49/0031 , H01J49/0036 , H01J49/022 , H01J49/067
Abstract: In one aspect, a method of modulating transmission of ions in a mass spectrometer is disclosed, which comprises generating an ion beam comprising a plurality of ions, directing the ion beam to an ion optic positioned in the path of the ion beam, wherein the ion optic includes at least one opening through which the ions can pass, and applying one or more voltage pulses at a selected duty cycle to said ion optic so as to obtain a desired attenuation of brightness of the ion beam passing through the ion optic, where a pulse width of said voltage pulses at said selected duty cycle is determined by identifying a pulse width on a calibration normalized ion intensity versus pulse width relation for said ions that corresponds to said desired attenuation on an ideal normalized ion intensity versus pulse width relation for said ions.
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公开(公告)号:US20240177985A1
公开(公告)日:2024-05-30
申请号:US18528491
申请日:2023-12-04
Applicant: Thermo Fisher Scientific (Bremen) GmbH
Inventor: Henning WEHRS , Johannes SCHWIETERS , Gerhard JUNG
CPC classification number: H01J49/063 , F16K1/2007 , H01J49/005 , H01J49/0077 , H01J49/022 , H01J49/065 , H01J49/067 , H01J49/068 , H01J49/105 , H01J49/421 , H01J49/4215
Abstract: An ion optical arrangement (1) for use in a mass spectrometer comprises a collision cell defining an ion optical axis along which ions may pass, electrodes comprising a set of parallel poles (11A, 11B, 11C) arranged in the collision cell, and a voltage source for providing voltages to the electrodes to produce electric fields. The ion optical arrangement is arranged for switching between a first operation mode in which the collision cell is pressurized and a second operation mode in which the collision cell is substantially evacuated. The ion optical arrangement is further arranged for producing a radio frequency electric focusing field in the first operation mode and a static electric focusing field in the second operation mode.
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公开(公告)号:US11972937B2
公开(公告)日:2024-04-30
申请号:US17057736
申请日:2019-05-31
Applicant: Micromass UK Limited
Inventor: Alastair Booth , Alvin Chua , Carl Chen , Marcus Dawber , Enchen Guo , Dennis Ong , Richard Tyldesley-Worster
CPC classification number: H01J49/147 , H01J49/067
Abstract: A filament assembly for mounting to a source assembly of a mass spectrometer, the filament assembly comprising a body having one of: an aperture to receive a corresponding spigot provided by a source assembly; or a spigot to be received in a corresponding aperture on a source assembly.
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公开(公告)号:US11967496B2
公开(公告)日:2024-04-23
申请号:US17580917
申请日:2022-01-21
Applicant: Fluidigm Canada Inc. , University of Ottawa
Inventor: Paul Corkum , Alexander V. Loboda
IPC: H01J49/04 , G01N33/68 , G02B21/33 , H01J37/20 , H01J37/28 , H01J49/00 , H01J49/02 , H01J49/06 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/40
CPC classification number: H01J49/0463 , G01N33/6848 , G01N33/6851 , G02B21/33 , H01J37/20 , H01J37/28 , H01J49/0004 , H01J49/0031 , H01J49/025 , H01J49/0418 , H01J49/067 , H01J49/105 , H01J49/142 , H01J49/161 , H01J49/164 , H01J49/40
Abstract: The present invention relates to the high resolution imaging of samples using imaging mass spectrometry (IMS) and to the imaging of biological samples by imaging mass cytometry (IMC™) in which labelling atoms are detected by IMS. LA-ICP-MS (a form of IMS in which the sample is ablated by a laser, the ablated material is then ionised in an inductively coupled plasma before the ions are detected by mass spectrometry) has been used for analysis of various substances, such as mineral analysis of geological samples, analysis of archaeological samples, and imaging of biological substances. However, traditional LA-ICP-MS systems and methods may not provide high resolution. Described herein are methods and systems for high resolution IMS and IMC.
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公开(公告)号:US20240055248A1
公开(公告)日:2024-02-15
申请号:US18384075
申请日:2023-10-26
Applicant: PerkinElmer Scientific Canada ULC
Inventor: Hamid Badiei , Brian Chan
CPC classification number: H01J49/068 , H01J49/105 , H01J49/04 , H01J49/067
Abstract: Certain configurations of a sampler cone and its use with a metal gasket to seal the sampler cone to a mass spectrometer interface are described. The sampler cone, interface or both may comprise one or more surface features. Coupling of the sampler cone to the interface can compress or crush the metal gasket to provide a seal between the sampler cone and the interface. For example, a crushing force provided by surface features of the sampler cone and interface can crush the gasket and provide a substantially fluid tight seal between the sampler cone and the interface.
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公开(公告)号:US11873219B2
公开(公告)日:2024-01-16
申请号:US17045961
申请日:2019-04-04
Applicant: SHELL OIL COMPANY
Inventor: Leonardo Spanu , Carolus Matthias Anna Maria Mesters
IPC: C01B3/30 , C01B32/162 , B01J23/755 , C01B3/56 , H01J49/06 , H01J49/10 , H01J49/24
CPC classification number: C01B3/30 , B01J23/755 , C01B3/56 , C01B32/162 , H01J49/067 , H01J49/105 , H01J49/24 , C01B2203/0277
Abstract: A method of operating a mass spectrometer vacuum interface, the vacuum interface comprising an evacuated expansion chamber downstream of a plasma ion source at atmospheric or relatively high pressure, the expansion chamber having a first aperture that interfaces with the plasma ion source to form an expanding plasma downstream of the first aperture and a second aperture downstream of the first aperture from the plasma for skimming the expanding plasma to form a skimmed expanding plasma; wherein the expansion chamber is pumped by an interface vacuum pump to provide an interface pressure in the chamber; the method comprising using a controller to automatically, or according to user input, control the throughput of the interface vacuum pump to control the interface pressure dependent on one or more operating modes of the spectrometer. A pressure gauge can be located in the expansion chamber and a feedback loop provided between the pressure gauge and controller.
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公开(公告)号:US11791149B2
公开(公告)日:2023-10-17
申请号:US17631393
申请日:2020-07-16
Applicant: Agilent Technologies, Inc.
Inventor: Tong Chen , Curt A. Flory , Gershon Perelman
CPC classification number: H01J49/067 , H01J37/12 , H01J2237/1215 , H01J2237/1534
Abstract: An electrostatic lens for transporting charged particles in an axial direction includes a first group of first electrodes configured to receive a first DC potential from a DC voltage source, and a second group of second electrodes configured to receive a second DC potential from the DC voltage source different from the first DC potential. The first electrodes are interdigitated with the second electrodes. The first group and/or the second group has a geometric feature that progressively varies along the axial direction. The lens generates an axial potential profile that progressively changes along the axial direction, and thereby reduces geometrical aberrations. The lens may be part of a charged particle processing apparatus such as, for example, a mass spectrometer or an electron microscope.
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公开(公告)号:US20230243986A1
公开(公告)日:2023-08-03
申请号:US18190483
申请日:2023-03-27
Applicant: Thermo Finnigan LLC
Inventor: Linfan LI , Jae C. SCHWARTZ , Oleg SILIVRA
CPC classification number: G01T1/28 , H01J49/0095 , H01J49/067 , H01J49/025
Abstract: A method of ion detection comprises: (a) setting electrical potentials of a dynode and a scintillator electrode of a Daly detector and of a focusing lens disposed at an ion inlet of the Daly detector so as to detect negatively charged ions received from a mass analyzer or mass filter; (b) transferring the negatively charged ions from the mass analyzer or mass filter to the Daly detector through the lens and detecting said negatively charged ions by a photodetector of the Daly detector; (c) setting electrical potentials of the dynode, the scintillator electrode and the focusing lens of the Daly detector so as to detect positively charged ions received from the mass analyzer or mass filter; and (d) transferring the positively charged ions from the mass analyzer or mass filter to the Daly detector through the lens and detecting said positively charged ions by the photodetector.
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公开(公告)号:US11676807B2
公开(公告)日:2023-06-13
申请号:US17545804
申请日:2021-12-08
Applicant: GMJ Technologies, Inc.
Inventor: Oluwatosin O. Dada
IPC: H01J49/16 , G01N27/447 , H01J49/02 , H01J49/06
CPC classification number: H01J49/167 , G01N27/44721 , H01J49/022 , H01J49/025 , H01J49/067
Abstract: Presented herein are apparatuses for use in capillary separations. An apparatus includes a coupling that integrates a capillary with a voltage source, a sheath liquid system, a fluid exit port, and a manifold. The coupling may be an elbow connector or equivalent. The manifold receives incident light from an incident light input, and emitted light is collected by a collected light output. The capillary enters the manifold at an input for the capillary, traverses the coupling, and terminates at the fluid exit port, for example an electrospray emitter. The capillary may also enter the manifold at an input for the capillary and terminates inside the manifold.
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