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公开(公告)号：US4245041A
公开(公告)日：1981-01-13
申请号：US858187
申请日：1977-12-07
申请人： Jerry W. Denney
发明人： Jerry W. Denney
摘要： An improved triglyceride assay and reagent system which provides the introduction of iron into a reaction mixture in which glycerol from hydrolyzed triglycerides is coupled to a NAD/NADH indicator system, and measuring the resultant change of the oxidation state of the iron by use of an iron chelator, thereby improving the sensitivity and performance of the assay.
摘要翻译： 改进的甘油三酸酯测定和试剂系统，其提供将铁引入反应混合物中，其中来自水解甘油三酸酯的甘油与NAD / NADH指示剂体系偶联，并通过使用铁测量所得到的铁的氧化态变化 螯合剂，从而提高了测定的灵敏度和性能。
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公开(公告)号：US4224034A
公开(公告)日：1980-09-23
申请号：US940350
申请日：1978-09-07
申请人： Jerry W. Denney , Mark C. Outcalt
发明人： Jerry W. Denney , Mark C. Outcalt
CPC分类号： G01N33/84 , G01N33/90 , Y10S436/91
摘要： The discovery of 9-(2-pyridyl)-acenaphtho[1,2-e]-as-triazine and its sulfonated form, having particular advantages when used as both a chelator and indicator of ferrous ions in organic or aqueous mediums; a process for the synthesis of those compounds in which hydrazine is used as both a reactant and as a solvent in production of intermediate compounds, eliminating the need of ethanol and the disadvantageous ether-extraction step; the use of N,N-dimethylformamide as a reaction solvent in the production of triazines; the use of the new triazine compounds to measure iron, transferrin, and UIBC/TIBC in biological systems; the use of dimethylsulfoxide and certain processes to eliminate the interferences commonly encountered in these assays; and the use of the triazine compounds to measure both total and/or reduced iron in a variety of matrices.
摘要翻译： 当用作有机或水性介质中的亚铁离子的螯合剂和指示剂时，发现9-（2-吡啶基） - 苊并[1,2-e] --as-三嗪及其磺化形式具有特别的优点; 合成这些化合物的方法，其中肼用作中间体化合物生产中的反应物和溶剂，不需要乙醇和不利的乙醚萃取步骤; 在制备三嗪时使用N，N-二甲基甲酰胺作为反应溶剂; 使用新的三嗪化合物来测量生物系统中的铁，转铁蛋白和UIBC / TIBC; 使用二甲基亚砜和某些方法来消除这些测定中常见的干扰; 以及使用三嗪化合物来测量各种基质中的总铁和/或还原铁。
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公开(公告)号：US4154929A
公开(公告)日：1979-05-15
申请号：US714481
申请日：1976-08-16
申请人： Mark C. Outcalt , Jerry W. Denney
发明人： Mark C. Outcalt , Jerry W. Denney
IPC分类号： C07D213/78 , C07D213/86 , G01N33/84 , G01N33/90 , C07D253/08
CPC分类号： C07D213/86 , G01N33/84
摘要： The discovery of 9-(2-pyridyl)-acenaphtho[ 1,2-e]-as-triazine and its sulfonated form, having particular advantages when used as both a chelator and indicator of ferrous ions in organic or aqueous mediums; a process for the synthesis of those compounds in which hydrazine is used as both a reactant and as a solvent in production of intermediate compounds, eliminating the need of ethanol and the disadvantageous ether-extraction step; the use of N,N-dimethylformamide as a reaction solvent in the production of triazines; the use of the new triazine compounds to measure iron, transferrin, and UIBC/TIBC in biological systems; the use of dimethylsulfoxide and certain processes to eliminate interferences commonly encountered in these assays; and the use of the triazine compounds to measure both total and/or reduced iron in a variety of matrices.
摘要翻译： 当用作有机或水性介质中的亚铁离子的螯合剂和指示剂时，发现9-（2-吡啶基） - 苊并[1,2-e] --as-三嗪及其磺化形式具有特别的优点; 合成这些化合物的方法，其中肼用作中间体化合物生产中的反应物和溶剂，不需要乙醇和不利的乙醚萃取步骤; 在制备三嗪时使用N，N-二甲基甲酰胺作为反应溶剂; 使用新的三嗪化合物来测量生物系统中的铁，转铁蛋白和UIBC / TIBC; 使用二甲亚砜和某些方法来消除这些测定中通常遇到的干扰; 以及使用三嗪化合物来测量各种基质中的总铁和/或还原铁。
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公开(公告)号：US4131429A
公开(公告)日：1978-12-26
申请号：US885600
申请日：1978-03-13
申请人： Jerry W. Denney
发明人： Jerry W. Denney
IPC分类号： C07D215/46 , G01N31/00 , G01N33/62 , G01N33/16
CPC分类号： C07D215/46 , G01N33/62 , Y10T436/171538
摘要： Urea assay or analysis process and reagents therefor, in which the assay involves a reaction between a sample of biological fluid and an acidic reagent solution of o-phthaldehyde and a chromogenic compound; the chromogenic compounds include certain substituted benzene compounds, certain substituted naphthalene compounds, certain aminopyrimidines, certain substituted quinolines, certain morpholino substituted quinolines and certain morpholino substituted naphthalenes.
摘要翻译： 尿素试验或其分析方法和试剂，其中测定涉及生物流体样品与邻苯二甲醛的酸性试剂溶液和显色化合物之间的反应; 显色化合物包括某些取代的苯化合物，某些取代的萘化合物，某些氨基嘧啶，某些取代的喹啉，某些吗啉取代的喹啉和某些吗啉取代的萘。
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公开(公告)号：US4105408A
公开(公告)日：1978-08-08
申请号：US841655
申请日：1977-10-13
申请人： Jerry W. Denney
发明人： Jerry W. Denney
IPC分类号： C07D215/46 , G01N31/00 , G01N33/62 , G01N33/16
CPC分类号： C07D215/46 , G01N33/62 , Y10T436/171538
摘要： A urea assay or analysis process and reagents therefor, in which the assay involves a reaction between a sample of biological fluid and an acidic reagent solution of o-phthaldehyde and a chromogenic compound; the chromogenic compounds include certain substituted benzene compounds, certain substituted naphthalene compounds, certain aminopyrimidines, certain substituted quinolines, certain morpholino substituted quinolines and certain morpholino substituted naphthalenes.
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公开(公告)号：US3547586A
公开(公告)日：1970-12-15
申请号：US3547586D
申请日：1967-06-05
申请人： JERRY W DENNEY , LARRY W DENNEY
发明人： DENNEY JERRY W , DENNEY LARRY W
CPC分类号： G01N33/84 , G01N2800/04 , Y10T436/166666
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公开(公告)号：US06326208B1
公开(公告)日：2001-12-04
申请号：US09463131
申请日：2000-01-18
申请人： Jerry W. Denney
发明人： Jerry W. Denney
IPC分类号： G01N3300
CPC分类号： G01N33/728 , Y10T436/146666 , Y10T436/25 , Y10T436/25125
摘要： Methods for assay of both total bilirubin and direct bilirubin in a sample. The inventive methods enable the amounts of total and direct (conjugated) bilirubin to be colorimetrically measured in about 5 minutes, and do not require the precipitation and removal of potentially interfering substances such as proteins prior to analysis. Novel stable reagents that solubilize the bilirubin and interfering substances are also provided. A novel total bilirubin reagent causes the oxidation of the total bilirubin in the sample, and the formation of a light-absorbing bilirubin chromophore detectable in the near-infrared region of the spectrum. A novel direct bilirubin reagent causes the oxidation of the direct bilirubin in the sample, and the formation of a light-absorbing bilirubin chromophore detectable in the near-infrared region of the spectrum, whereas the chromophore formed by the unconjugated bilirubin is substantially colorless.
摘要翻译： 检测样品中总胆红素和直接胆红素的方法。 本发明方法使得总共和直接（共轭）胆红素的量在约5分钟内进行比色测定，并且在分析之前不需要沉淀和除去潜在的干扰物质如蛋白质。 还提供了增溶胆红素和干扰物质的新型稳定试剂。 一种新的总胆红素试剂导致样品中总胆红素氧化，并形成在光谱的近红外区域可检测的光吸收型胆红素发色团。 一种新颖的直接胆红素试剂导致样品中直接胆红素的氧化，并且在光谱的近红外区域形成可吸收的光吸收型胆红素发色团，而由非共轭胆红素形成的发色团基本上是无色的。
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公开(公告)号：US5151370A
公开(公告)日：1992-09-29
申请号：US596942
申请日：1990-10-11
申请人： Jerry W. Denney
发明人： Jerry W. Denney
摘要： A method utilizing a novel reagent for the assay (determination)of serum iron.The serum iron assay reagent is a single, stable reagent, which includes the chromogen chromazurol B (CAB), chromazurol S (CAS), or an alkali metal, alkaline earth metal, rubidium or ammonium base addition salt of CAB or CAS, a surfactant that forms a ternary complex with iron and the chromogen, a buffer, and dimethylsulfoxide.
摘要翻译： 一种利用新型试剂测定血清铁的方法。 血清铁测定试剂是一种稳定的试剂，其包括色原铬色谱柱B（CAB），色谱柱S（CAS）或CAB或CAS的碱金属，碱土金属，铷或铵基加成盐，表面活性剂 它们与铁和色原子形成三元复合物，缓冲剂和二甲基亚砜。
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公开(公告)号：US4131430A
公开(公告)日：1978-12-26
申请号：US885597
申请日：1978-03-13
申请人： Jerry W. Denney
发明人： Jerry W. Denney
IPC分类号： C07D215/46 , G01N31/00 , G01N33/62 , G01N33/16
CPC分类号： C07D215/46 , G01N33/62 , Y10T436/171538
摘要： Urea assay or analysis process and reagents therefor, in which the assay involves a reaction between a sample of biological fluid and an acidic reagent solution of o-phthaldehyde and a chromogenic compound; the chromogenic compounds include certain substituted benzene compounds, certain substituted naphthalene compounds, certain aminopyrimidines, certain substituted quinolines, certain morpholino substituted quinolines and certain morpholino substituted naphthalenes.
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公开(公告)号：US4131425A
公开(公告)日：1978-12-26
申请号：US885596
申请日：1978-03-13
申请人： Jerry W. Denney
发明人： Jerry W. Denney
IPC分类号： C07D215/46 , G01N31/00 , G01N33/62 , G01N33/16
CPC分类号： C07D215/46 , G01N33/62 , Y10T436/171538
摘要： Urea assay or analysis process and reagents therefor, in which the assay involves a reaction between a sample of biological fluid and an acidic reagent solution of o-phthaldehyde and a chromogenic compound; the chromogenic compounds include certain substituted benzene compounds, certain substituted naphthalene compounds, certain aminopyrimidines, certain substituted quinolines, certain morpholino substituted quinolines and certain morpholino substituted naphthalenes.
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