High resolution mobility analysis of large charge-reduced electrospray ions

    公开(公告)号:US10163615B2

    公开(公告)日:2018-12-25

    申请号:US15076103

    申请日:2016-03-21

    IPC分类号: H01J49/16 H01J49/00

    摘要: Achieving high conversion of large multiply charged biological ions into low charge states involves requirements difficult to reconcile when high transmission and good spray quality (resulting in narrow mobility distributions) are sought. These multiple goals are achieved in this invention by partially isolating different regions from each other with electrostatic barriers relatively transparent to ions, such as metallic grids. One such region requires high electric fields for ion generation. The other region, used for ion recombination, is approximately field-free. In an alternative arrangement intended for charge reduction in sub-millisecond times, two sources of ions with opposite polarities are placed contiguously, with a grid in between. In all cases, ion crossing through grids into field free regions is effectively driven by space charge.

    Method for detecting atmospheric vapors at parts per quadrillion (PPQ) concentrations
    2.
    发明授权
    Method for detecting atmospheric vapors at parts per quadrillion (PPQ) concentrations 有权
    用于检测每千瓦(PPQ)浓度的大气蒸气的方法

    公开(公告)号:US09297785B2

    公开(公告)日:2016-03-29

    申请号:US13532146

    申请日:2012-06-25

    摘要: Improvements are provided in the detection of atmospheric vapors by ionizing them near ambient pressure, and analyzing them as ions. Lowest detection limits of parts per quadrillion (ppq) concentrations are enabled by a combination of improvements, including the use of a filter to remove occasional intense signal from explosive particles. Several sources of chemical background are identified and solutions for their reduction or elimination are presented. Gains in response time may be achieved by operating at elevated temperature. When the ionizer is an electrospray source, the use of high boiling point solvents is indicated. An increased selectivity is achieved by operating a differential mobility analyzer (DMA) in series with a mass spectrometer. However, ppq sensitivities require various improvements in the DMA system including a special coupling to the ionizer, controlling the temperature in the DMA pump circuit, avoidance of induction on the DMA electrodes from heating devices, etc.

    摘要翻译: 通过在大气压附近电离大气蒸气并分析它们作为离子,提供了改进。 通过改进的组合实现了每千瓦(ppq)浓度的最低检测限,包括使用过滤器去除爆炸性颗粒的偶然强烈信号。 确定了化学背景的几个来源,并提出了其减少或消除的解决方案。 响应时间的增益可以通过在高温下运行来实现。 当电离器是电喷雾源时,指示使用高沸点溶剂。 通过与质谱仪串联操作差示迁移率分析仪(DMA)来实现增加的选择性。 然而,ppq灵敏度需要DMA系统的各种改进,包括与离子发生器的特殊耦合,控制DMA泵电路中的温度,避免加热装置上DMA电极的感应等。

    Social media platform
    3.
    发明授权
    Social media platform 有权
    社交媒体平台

    公开(公告)号:US08910076B2

    公开(公告)日:2014-12-09

    申请号:US13330536

    申请日:2011-12-19

    申请人: Juan Fernandez

    发明人: Juan Fernandez

    摘要: A machine-controlled method may include creating a tile profile including multiple tiles, visually presenting the tile profile using a display, and storing the tile profile. The method may further include adding, removing, and editing the tiles and utilizing tile stacks. The method may further include any of a number of tile scrolling mechanisms.

    摘要翻译: 机器控制的方法可以包括创建包括多个瓦片的瓦片轮廓,使用显示器可视地呈现瓦片轮廓,以及存储瓦片轮廓。 该方法还可以包括添加,移除和编辑瓦片并利用瓦片堆叠。 该方法还可以包括多个瓦片滚动机构中的任何一个。

    Flex chair
    4.
    发明授权
    Flex chair 失效
    柔软的椅子

    公开(公告)号:US08540314B2

    公开(公告)日:2013-09-24

    申请号:US12912960

    申请日:2010-10-27

    申请人: Juan Fernandez

    发明人: Juan Fernandez

    IPC分类号: A47C9/00

    CPC分类号: A47C9/002 A47C3/30

    摘要: A chair having a seat, a first support base and an upright elongated support element. The upright elongated support element has a first point and a second point, with the first point connecting to the seat and the second point connecting to the first support base. The first support base is bolstered by a resilient component since the resilient component is disposed beneath the first support base. The resilient component is capable of providing cushioning to the first support base is also capable of providing a full axial rotation to said upright elongated support element.

    摘要翻译: 具有座椅,第一支撑底座和直立细长支撑元件的椅子。 直立的细长支撑元件具有第一点和第二点,第一点连接到座,而第二点连接到第一支撑基座。 第一支撑基座由弹性部件支撑,因为弹性部件设置在第一支撑基座的下方。 弹性部件能够为第一支撑基座提供缓冲,还能够向所述直立的细长支撑元件提供完全的轴向旋转。

    Vehicle protection device
    5.
    发明授权
    Vehicle protection device 失效
    车辆保护装置

    公开(公告)号:US08496267B2

    公开(公告)日:2013-07-30

    申请号:US13316747

    申请日:2011-12-12

    IPC分类号: B60J11/00

    摘要: A protection device for the outside of a vehicle is described. An impact absorbing structure is placed on the outside of a vehicle and is anchored to the vehicle using a strap. The strap is secured between the doorframe and the roof of the vehicle and allows the impact absorbing structure to hang horizontally along the outside of the vehicle. Any object that would otherwise impact and damage the vehicle, such as the door of a neighboring car in a parking lot, is intercepted by the protection device.

    摘要翻译: 描述了用于车辆外部的保护装置。 冲击吸收结构被放置在车辆的外部并且使用带固定到车辆上。 带子被固定在车门框架和车辆的车顶之间,并允许冲击吸收结构沿着车辆的外部水平地悬挂。 否则会影响和损坏车辆的任何物体,例如停车场中的相邻汽车的门,被保护装置拦截。

    SOCIAL MEDIA PLATFORM
    6.
    发明申请
    SOCIAL MEDIA PLATFORM 有权
    社会媒体平台

    公开(公告)号:US20120154444A1

    公开(公告)日:2012-06-21

    申请号:US13330536

    申请日:2011-12-19

    申请人: Juan Fernandez

    发明人: Juan Fernandez

    IPC分类号: G06F17/00 G06T11/20 G09G5/00

    摘要: A machine-controlled method may include creating a tile profile including multiple tiles, visually presenting the tile profile using a display, and storing the tile profile. The method may further include adding, removing, and editing the tiles and utilizing tile stacks. The method may further include any of a number of tile scrolling mechanisms.

    摘要翻译: 机器控制的方法可以包括创建包括多个瓦片的瓦片轮廓,使用显示器可视地呈现瓦片轮廓,以及存储瓦片轮廓。 该方法还可以包括添加,移除和编辑瓦片并利用瓦片堆叠。 该方法还可以包括多个瓦片滚动机构中的任何一个。

    Nail groomer
    7.
    发明授权
    Nail groomer 失效
    指甲花

    公开(公告)号:US08201565B2

    公开(公告)日:2012-06-19

    申请号:US12725645

    申请日:2010-03-17

    IPC分类号: A45D29/05 A45D29/04 A45D29/20

    CPC分类号: A45D29/05 A45D29/20

    摘要: The invention is a hand held nail and foot groomer for people, which includes a spherical nail groomer body having at least one compartment for batteries and tips; a semi-spherical tip cover assembly having an opening, being in substantial contact to the nail groomer body and being movably connected to the nail groomer body; a combination battery, motor and tip compartment; a tip assembly for attachment of various shapes and sizes of nail files and brushes. The preferred embodiment of this invention is one in which the nail body optionally includes a flat bottom section which includes one or more detachable ringed or recessed sections, said ring sections or recessed sections capable of holding rounded and optionally recessed files and/or pumice stones and/emery files and/or foot scarpers useful in grooming feet.

    摘要翻译: 本发明是一种用于人的手持式指甲和足部凹槽,其包括具有至少一个用于电池和尖端的隔间的球形指甲整形体; 具有开口的半球形末端盖组件,其与所述指甲整体主体基本上接触并且可移动地连接到所述指甲整形体; 组合电池,电机和提示舱; 用于附接各种形状和尺寸的指甲锉和刷子的尖端组件。 本发明的优选实施例是其中钉体可选地包括平底部分,其包括一个或多个可拆卸的环形或凹陷部分,所述环形部分或能够保持圆形和任选凹陷的文件和/或浮石的凹部, / emery文件和/或脚踏板可用于修脚。

    Agility device
    8.
    发明授权
    Agility device 失效
    敏捷设备

    公开(公告)号:US07993253B2

    公开(公告)日:2011-08-09

    申请号:US12380087

    申请日:2009-02-24

    申请人: Juan Fernandez

    发明人: Juan Fernandez

    IPC分类号: A63B22/14

    摘要: The agility device is an article of manufacture comprising a base, a stabilized inflatable support disposed on the base, and a top platform positioned on the stabilized inflatable support. The device also has optional handles and expandable base supports for added stability. The device is primarily for use as an exercise device, but also has value as an agility training tool to help users improve their balance and agility, and to improve their reflexes. It is useful for exercise, physical therapy, and for entertainment.

    摘要翻译: 敏捷装置是一种制品,其包括基座,设置在基座上的稳定的可充气支撑件和位于稳定的可充气支架上的顶部平台。 该设备还具有可选的手柄和可扩展的基座支架,以增加稳定性。 该设备主要用作锻炼设备,但也具有作为敏捷性训练工具的价值,可帮助用户提高他们的平衡和敏捷性,并改善其反应。 它对于运动,物理治疗和娱乐是有用的。

    METHOD AND APPARATUS TO ACCURATELY DISCRIMINATE GAS PHASE IONS WITH SEVERAL FILTERING DEVICES IN TANDEM
    9.
    发明申请
    METHOD AND APPARATUS TO ACCURATELY DISCRIMINATE GAS PHASE IONS WITH SEVERAL FILTERING DEVICES IN TANDEM 有权
    在TANDEM中精确地分离气相相关离子的方法和装置,具有多个过滤装置

    公开(公告)号:US20110057096A1

    公开(公告)日:2011-03-10

    申请号:US12946435

    申请日:2010-11-15

    IPC分类号: H01J49/00

    摘要: A method for fast and accurate recognition of species contained in trace amounts in complex mixtures such as ambient air or biological fluids is taught based on the use in tandem of one or several differential mobility analyzers (DMAs) and possibly also a mass spectrometer (MS), all arranged in series. The two DMAs operate in different regions of the ion drag versus drift velocity curve (for instance, linear versus nonlinear regions), hence separating according to more than one independently discriminating parameters of the ion. Very high discrimination can be achieved even with a single stage of mass spectrometric separation by selecting a narrow range of ions with the DMA, and analyzing them in the MS, first without fragmentation, and then with fragmentation. This process does not require necessarily a tandem MS when fragmentation takes place in the inlet region of the MS. Fast and accurate discrimination is possible in single ion monitoring mode (SIM) for a large number of targeted species, even with relatively inexpensive and light single quadrupole MS systems, where the various filters placed in series would open pre-configured narrow windows suitable for passage of each ion in a list.

    摘要翻译: 基于一个或多个差分迁移率分析仪(DMA)和可能还有质谱仪(MS)串联使用的方法,教导了在复杂混合物如环境空气或生物流体中快速和准确地识别微量物质的方法, ,全部排列在一起。 两个DMA在离子阻力对漂移速度曲线(例如,线性对非线性区域)的不同区域中操作,因此根据离子的多于一个独立鉴别参数进行分离。 即使通过使用DMA选择窄范围的离子,并且在MS中分析它们,也可以通过单阶段质谱分离来实现非常高的辨别,首先没有碎裂,然后是碎裂。 当MS的入口区域发生碎裂时,该过程不一定需要串联MS。 即使使用相对便宜又轻的单一四极杆MS系统,单个离子监测模式(SIM)对于大量目标物种可以进行快速准确的鉴别,其中各种过滤器串联放置可以打开预先配置的适合通过的窄窗口 的列表中的每个离子。