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公开(公告)号：US5368859A
公开(公告)日：1994-11-29
申请号：US84777
申请日：1993-06-29
IPC分类号： A61K6/00 , A61K9/00 , A61K9/16 , A61K31/74 , A61K33/42 , A61L24/00 , A61L27/00 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , B29C41/08 , B29C67/06 , A61F2/00
CPC分类号： A61K9/0024 , A61K31/74 , A61K33/42 , A61K6/0038 , A61K6/0041 , A61K9/0063 , A61K9/1647 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , A61L31/148 , B29C41/08 , B29C67/06 , A61L2300/404 , A61L2300/406 , A61L2300/412 , A61L2300/414 , A61L2300/604 , Y10S514/90
摘要： Methods are described for assisting the restoration of periodontal tissue in a periodontal pocket and for retarding migration of epithelial cells along the root surface of a tooth. The methods involve placement of an in-situ forming biodegradable barrier adjacent the surface of a tooth. The barrier is microporous and includes pores of defined size. The barrier can include a biologically active agent.
摘要翻译： 描述了用于协助牙周袋中牙周组织恢复并延缓上皮细胞沿牙根表面的迁移的方法。 该方法涉及在牙齿表面附近放置原位形成的可生物降解的屏障。 屏障是微孔的，并且包括具有规定尺寸的孔。 屏障可以包括生物活性剂。
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公开(公告)号：US5324520A
公开(公告)日：1994-06-28
申请号：US46396
申请日：1993-04-13
CPC分类号： A61B5/411 , A61B5/02411 , A61B5/0422 , A61B5/0448 , A61B5/4362 , A61B5/4547 , Y10S436/829 , Y10S514/953 , Y10S514/963
摘要： A polymeric controlled delivery system is provided for use in treating periodontal disease. The delivery system in a variety of forms is placed directly in the infected gingival tissue where the chemotherapeutic agent is slowly released into the tissue and into the infected periodontal pocket by means of the gingival crevicular fluid originating in the gingival tissue.
摘要翻译： 提供用于治疗牙周病的聚合物控制递送系统。 各种形式的递送系统直接放置在感染的牙龈组织中，其中化学治疗剂通过源自牙龈组织的牙龈沟液缓慢释放到组织中并进入感染的牙周袋中。
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公开(公告)号：US5324519A
公开(公告)日：1994-06-28
申请号：US783512
申请日：1991-10-28
IPC分类号： A61K6/083 , A61K6/00 , A61K9/00 , A61K9/16 , A61K31/74 , A61K33/42 , A61K39/00 , A61K45/00 , A61K47/02 , A61K47/26 , A61K47/30 , A61K47/34 , A61L24/00 , A61L27/00 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , B29C41/08 , B29C41/12 , B29C67/06 , A61F2/00
CPC分类号： A61K9/0024 , A61K31/74 , A61K33/42 , A61K47/34 , A61K6/0044 , A61K9/0063 , A61K9/1647 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , A61L31/148 , B29C41/08 , B29C41/12 , B29C67/06 , A61L2300/406 , A61L2300/412 , A61L2300/602 , A61L2300/604
摘要： The invention is directed to a composition composed of a thermoplastic or thermosetting polymer which is capable of forming a biodegradable and/or bioerodible microporous, solid or gelatinous polymer matrix. The matrix is useful as an implant in animals for enhancing regeneration of cells and tissue, such as bone and nerve cells, or for delivery of biologically-active substances to tissue or organs. The composition is administered to an implant site as a liquid. The invention also includes a method of preventing and treating disorders and diseases, such as bone or nerve growth disorders, or of altering body functions such as birth control, using the compositions and implants of the invention.
摘要翻译： 本发明涉及由热塑性或热固性聚合物组成的组合物，其能够形成可生物降解和/或生物腐蚀性微孔，固体或凝胶状聚合物基质。 该基质可用作动物中的植入物，用于增强细胞和组织的再生，例如骨和神经细胞，或将生物活性物质递送至组织或器官。 将组合物作为液体施用于植入部位。 本发明还包括使用本发明的组合物和植入物来预防和治疗诸如骨骼或神经生长障碍的疾病和疾病或改变身体功能例如避孕的方法。
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公开(公告)号：US5599552A
公开(公告)日：1997-02-04
申请号：US249630
申请日：1994-05-26
IPC分类号： A61K6/083 , A61K6/00 , A61K9/00 , A61K9/16 , A61K31/74 , A61K33/42 , A61K39/00 , A61K45/00 , A61K47/02 , A61K47/26 , A61K47/30 , A61K47/34 , A61L24/00 , A61L27/00 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , B29C41/08 , B29C41/12 , B29C67/06 , A61F2/00
CPC分类号： A61K9/0024 , A61K31/74 , A61K33/42 , A61K47/34 , A61K6/0044 , A61K9/0063 , A61K9/1647 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , A61L31/148 , B29C41/08 , B29C41/12 , B29C67/06 , A61L2300/406 , A61L2300/412 , A61L2300/602 , A61L2300/604
摘要： The invention is directed to a composition composed of a thermoplastic or thermosetting polymer which is capable of forming a biodegradable and/or bioerodible microporous, solid or gelatinous polymer matrix. The matrix is useful as an implant in animals for enhancing regeneration of cells and tissue, such as bone and nerve cells, or for delivery of biologically-active substances to tissue or organs. The composition is administered to an implant site as a liquid. The invention also includes a method of preventing and treating disorders and diseases, such as bone or nerve growth disorders, or of altering body functions such as birth control, using the compositions and implants of the invention.
摘要翻译： 本发明涉及由热塑性或热固性聚合物组成的组合物，其能够形成可生物降解和/或生物腐蚀性微孔，固体或凝胶状聚合物基质。 该基质可用作动物中的植入物，用于增强细胞和组织的再生，例如骨和神经细胞，或将生物活性物质递送至组织或器官。 将组合物作为液体施用于植入部位。 本发明还包括使用本发明的组合物和植入物来预防和治疗诸如骨骼或神经生长障碍的疾病和疾病或改变身体功能例如避孕的方法。
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公开(公告)号：US5077049A
公开(公告)日：1991-12-31
申请号：US384416
申请日：1989-07-24
IPC分类号： A61K6/00 , A61K9/00 , A61K9/16 , A61K31/74 , A61K33/42 , A61L24/00 , A61L27/00 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , B29C41/08 , B29C67/06
CPC分类号： A61K9/0024 , A61K31/74 , A61K33/42 , A61K6/0038 , A61K6/0041 , A61K9/0063 , A61K9/1647 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , A61L31/148 , B29C41/08 , B29C67/06 , A61L2300/404 , A61L2300/406 , A61L2300/412 , A61L2300/414 , A61L2300/604 , Y10S514/90
摘要： Methods are described for assisting the restoration of periodontal tissue in a periodontal pocket and for retarding migration of epithelial cells along the root surface of a tooth. The methods involve placement of an in-situ forming biodegradable barrier adjacent the surface of a tooth. The barrier is microporous and includes pores of defined size. The barrier can include a biologically active agent.
摘要翻译： 描述了用于协助牙周袋中牙周组织恢复并延缓上皮细胞沿牙根表面的迁移的方法。 该方法涉及在牙齿表面附近放置原位形成的可生物降解的屏障。 屏障是微孔的，并且包括具有规定尺寸的孔。 屏障可以包括生物活性剂。
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公开(公告)号：US4039636A
公开(公告)日：1977-08-02
申请号：US374458
申请日：1973-06-28
申请人： Kenneth G. Claus , Jack A. Rogers
发明人： Kenneth G. Claus , Jack A. Rogers
摘要： Magnesium dialkyl phosphates capable of thickening or gelling nonpolar organic solvents are prepared by reacting a dialkyl acid phosphate with a magnesium oxide, hydroxide, or carbonate in organic solvent solution in the presence of a small amount of water within defined limits of time, temperature, mole ratios of reactants, and size of alkyl groups. The products are useful as thickening agents and vapor pressure depressants for nonpolar solvents.
摘要翻译： 能够增稠或胶凝非极性有机溶剂的二烷基磷酸镁可以通过在少量水存在下，在规定的时间，温度，摩尔数范围内使有机溶剂溶液中的二烷基酸式磷酸酯与氧化镁，氢氧化物或碳酸酯反应来制备 反应物的比例和烷基的大小。 该产品可用作非极性溶剂的增稠剂和蒸汽抑压剂。
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