公开(公告)号：US4339384A

公开(公告)日：1982-07-13

申请号：US54626

申请日：1979-07-03

申请人： Jacques G. Maillard ,  Jacky Legeai

发明人： Jacques G. Maillard ,  Jacky Legeai

IPC分类号： C07D405/12 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/443 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/55 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P25/00 ,  C07D307/79 ,  C07D405/04

CPC分类号： C07D307/79 ,  Y10S514/821

摘要： This invention relates to compounds having the general formula: ##STR1## in which ##STR2## is selected from: a radical ##STR3## in which R'.sub.1 is hydrogen and R'.sub.2 is selected from hydrogen; C.sub.1-6 alkyl; C.sub.2-6 alkenyl; C.sub.2-6 alkynyl; phenyl; phenyl C.sub.1-6 alkyl; mono-, di- and trimethoxyphenyl C.sub.1-6 alkyl; C.sub.1-6 alkoxy; benzyloxy; di-C.sub.1-6 alkylamino-C.sub.1-6 alkyl; C.sub.1-6 hydroxyalkyl; C.sub.1-6 alkyloxycarbonyl-C.sub.1-6 alkyl;a radical ##STR4## in which R".sub.1 and R".sub.2 are C.sub.1-6 alkyl; a radical ##STR5## in which n is selected from 4, 5 and 6; the radical ##STR6## and the radical ##STR7## and their pharmacologically acceptable inorganic and organic acid addition salts.Said compounds are therapeutically useful for the treatment of dysrhythmia.

摘要翻译： 本发明涉及具有以下通式的化合物：其中选自：其中R 1是氢并且R 2选自氢的基团 C 1-6烷基; C 2-6烯基; C 2-6炔基; 苯基; 苯基C 1-6烷基; 单，二和三甲氧基苯基C 1-6烷基; C 1-6烷氧基 苄氧基; 二-C 1-6烷基氨基-C 1-6烷基; C 1-6羟基烷基; C 1-6烷氧基羰基-C 1-6烷基; 其中R“1和R”2为C 1-6烷基的基团“IMAGE” 其中n选自4,5和6的激进的 激进的“IMAGE”和激进的“IMAGE”及其药理学上可接受的无机和有机酸加成盐。 所述化合物对于治疗心律失常是治疗上有用的。

公开(公告)号：US4443468A

公开(公告)日：1984-04-17

申请号：US355331

申请日：1982-03-05

申请人： J. Georges Maillard ,  Jacky Legeai

发明人： J. Georges Maillard ,  Jacky Legeai

IPC分类号： C07D405/12 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/443 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/55 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P25/00 ,  C07D307/79 ,  C07D405/04

CPC分类号： C07D307/79 ,  Y10S514/821

摘要： This invention relates to compounds having the general formula: ##STR1## in which ##STR2## is selected from: a radical ##STR3## in which R'.sub.1 is hydrogen and R'.sub.2 is selected from hydrogen; C.sub.1-6 alkyl; C.sub.2-6 alkenyl; C.sub.2-6 alkynyl; phenyl; phenyl C.sub.1-6 alkyl; mono-, di- and trimethoxyphenyl C.sub.1-6 alkyl; C.sub.1-6 alkoxy; benzyloxy; di-C.sub.1-6 alkylamino-C.sub.1-6 alkyl; C.sub.1-6 hydroxyalkyl; C.sub.1-6 alkyloxycarbonyl-C.sub.1-6 alkyl; or R'.sub.1 and R'.sub.2 are joined to form a heterocyclic ring;and their pharmacologically acceptable inorganic and organic acid addition salts.Said compounds are therapeutically useful for the treatment of dysrhythmia.

摘要翻译： 本发明涉及具有以下通式的化合物：其中选自：其中R 1是氢并且R 2选自氢的基团 C 1-6烷基; C 2-6烯基; C 2-6炔基; 苯基; 苯基C 1-6烷基; 单，二和三甲氧基苯基C 1-6烷基; C 1-6烷氧基; 苄氧基; 二-C 1-6烷基氨基-C 1-6烷基; C 1-6羟基烷基; C 1-6烷氧基羰基-C 1-6烷基; 或R'1和R'2连接形成杂环; 及其药理学上可接受的无机酸和有机酸加成盐。 所述化合物对于治疗心律失常是治疗上有用的。

公开(公告)号：US4208420A

公开(公告)日：1980-06-17

申请号：US950394

申请日：1978-10-11

申请人： Jacques Maillard ,  Pierre Delaunay ,  Jacky Legeai

发明人： Jacques Maillard ,  Pierre Delaunay ,  Jacky Legeai

IPC分类号： C07D277/64 ,  A61K31/425 ,  A61K31/428 ,  A61P1/04 ,  A61P3/04 ,  A61P9/02 ,  A61P9/12 ,  A61P25/04 ,  A61P25/26 ,  A61P29/00 ,  C07D277/30 ,  C07D277/56 ,  C07D277/62 ,  A61K31/38 ,  C07D277/60

CPC分类号： C07D277/62 ,  C07D277/30 ,  C07D277/56

摘要： This invention relates to compounds having the general formula: ##STR1## and their pharmaceutically acceptable acid addition salts having the formula: ##STR2## in which: R represents hydrogen or a C.sub.1-4 alkyl radical,R' represents hydrogen or a C.sub.1-4 alkyl radical,m is 0, 1, 2 or 3,n is 3, 2, 1 or 0,the sum m+n being always equal to 3, andX.sup.- represents an anion formed by a pharmaceutically acceptable acid.Said compounds are typically useful as analgesic agents and as stimulants of the sympathetic nervous system, and also as central and peripheral vasoregulator agents.

摘要翻译： 本发明涉及具有以下通式的化合物：其中：R表示氢或C1-4烷基，R'表示（I）化合物及其药学上可接受的酸加成盐，其具有下式： 氢或C 1-4烷基，m为0,1,2或3，n为3，2，1或0，总和m + n总是等于3，X代表由药学上形成的阴离子 可接受的酸。