公开(公告)号：US20070225680A1

公开(公告)日：2007-09-27

申请号：US11277051

申请日：2006-03-21

Applicant: James Biggins

Inventor： James Biggins

IPC: A61M25/00 ,  B32B37/00

CPC classification number: B29C71/0009 ,  A61L29/06 ,  A61L29/141 ,  A61M25/0009 ,  A61M25/0012 ,  A61M25/0045 ,  A61M25/005 ,  A61M25/0054 ,  A61M25/0069 ,  A61M25/0662 ,  A61M2025/0081 ,  B29L2031/7542 ,  C08L77/00

Abstract: A guiding catheter for placement in a patient's vessel. The catheter includes an elongate hollow shaft with open proximal and distal ends and a bore extending there through. The catheter shaft includes an inner liner, a metallic reinforcement layer overlying the inner liner, and a unitary outer jacket covering the reinforcement layer. A distal portion of the outer jacket of the catheter shaft is chemically softened to be more flexible than a proximal portion of the outer jacket. A connector fitting is mounted at the proximal end of the shaft in communication with the bore and a distal tip is attached to the distal end of the shaft. A method of manufacturing the guiding catheter is also disclosed.

Abstract translation: 用于放置在患者血管中的引导导管。 导管包括具有开放的近端和远端的细长空心轴和在其上延伸的孔。 导管轴包括内衬，覆盖内衬的金属加强层和覆盖加强层的整体外护套。 导管轴的外护套的远端部分被化学软化以比外护套的近端部分更柔韧。 连接器配件安装在与孔连通的轴的近端处，并且远侧末端附接到轴的远端。 还公开了一种制造引导导管的方法。

公开(公告)号：US20250073014A1

公开(公告)日：2025-03-06

申请号：US18909484

申请日：2024-10-08

Applicant: James Biggins ,  Rajesh Kumar

Inventor： James BIGGINS ,  Rajesh Kumar

IPC: A61F2/01

Abstract: The present invention relates generally to medical compositions, methods and devices/systems for treating vascular diseases. More particularly, the invention relates to medical methods, devices and kits for distributing drug to surrounding vascular tissue to treat neointimal growth. More specifically, the described invention is intended to overcome shortcomings of existing treatments for peripheral artery disease (PAD). Devices and methods of the present invention are specifically intended to treat patients with PAD involving the infrapopliteal (tibial) arteries, e.g., patients having a clinical indication for treatment below the knees (e.g., claudication and/or critical limb ischemia (CLI), and patients with complex disease states, for reducing one or more of morbidity; treatment complications in treated patient populations, a reduction in target lesion revascularization (TLR) rates; and a reduction in patients populations requiring any type of leg amputation.

公开(公告)号：US20110060398A1

公开(公告)日：2011-03-10

申请号：US12872298

申请日：2010-08-31

Applicant: Srinath Tupil ,  James Biggins ,  William Bertolino

Inventor： Srinath Tupil ,  James Biggins ,  William Bertolino

IPC: A61F2/82

CPC classification number: A61F2/88 ,  A61F2/07 ,  A61F2/86 ,  A61F2/90 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2002/9528 ,  A61F2002/9534 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0078 ,  A61F2250/0039

Abstract: An endoprosthesis includes a stent structure having an elongate member longitudinal portions of which overlap to define the crossover structures. The stent structure may also include loop structures, which are contiguous with the crossover structures, through which a filament extends. A guard structure is secured to the stent structure and located adjacent to the crossover structures to obstruct displacement of the filament between the longitudinal portions of the elongate member of the crossover structures. A method for operating the endoprosthesis includes displacing the loop structures toward one another along the filament to displaced positions relative to the suture structure for reducing the respective profiles of the stent structure and patch structure.

Abstract translation: 内假体包括具有细长构件的支架结构，其长度部分重叠以限定交叉结构。 支架结构还可以包括与交叉结构邻接的环结构，细丝延伸穿过该结构。 保护结构被固定到支架结构并且位于交叉结构附近以阻止细丝在交叉结构的细长构件的纵向部分之间的移位。 用于操作内用假体的方法包括将所述环结构相对于所述细丝相互朝向彼此移动以相对于所述缝合线结构移位以减少所述支架结构和贴片结构的相应轮廓。

公开(公告)号：US08961501B2

公开(公告)日：2015-02-24

申请号：US12884466

申请日：2010-09-17

Applicant: Peter Jarrett ,  Rami El Hayek ,  Michael Bassett ,  James Biggins

Inventor： Peter Jarrett ,  Rami El Hayek ,  Michael Bassett ,  James Biggins

IPC: A61B18/18 ,  A61F2/00 ,  A61K9/00 ,  A61K9/06 ,  A61K47/34

CPC classification number: A61K9/0048 ,  A61K9/06 ,  A61K47/34

Abstract: Materials and methods of treating an eye with a hydrogel formed on the eye. Embodiments are provided that include post-keratectomy bandages. A method of treating a patient by application of a hydrogel bandage to a cornea by providing a first hydrogel precursor in a dry form immobilized in a first deposit at a first location in a well, providing a second hydrogel precursor in a dry form immobilized in a second deposit at a second location in the well, mixing the deposits together to form a mixture, and transferring at least some of the mixture to the cornea, with the mixture forming a covalently crosslinked hydrogel on the cornea.

Abstract translation: 用眼睛上形成的水凝胶治疗眼睛的材料和方法。 提供了包括后角膜切除术绷带的实施例。 一种通过将水凝胶绷带应用于角膜来治疗患者的方法，该方法通过在第一位置上提供固定在第一沉积物中的以干燥形式固定的第一水凝胶前体，提供固定在孔中的干燥形式的第二水凝胶前体 第二次沉积在井的第二位置，将沉积物混合在一起形成混合物，并将至少一些混合物转移到角膜，混合物在角膜上形​​成共价交联的水凝胶。

公开(公告)号：US08784473B2

公开(公告)日：2014-07-22

申请号：US12872298

申请日：2010-08-31

Applicant: Srinath Tupil ,  James Biggins ,  William Bertolino

Inventor： Srinath Tupil ,  James Biggins ,  William Bertolino

IPC: A61F2/88

CPC classification number: A61F2/88 ,  A61F2/07 ,  A61F2/86 ,  A61F2/90 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2002/9528 ,  A61F2002/9534 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0078 ,  A61F2250/0039

Abstract: An endoprosthesis includes a stent structure having an elongate member longitudinal portions of which overlap to define the crossover structures. The stent structure may also include loop structures, which are contiguous with the crossover structures, through which a filament extends. A guard structure is secured to the stent structure and located adjacent to the crossover structures to obstruct displacement of the filament between the longitudinal portions of the elongate member of the crossover structures. A method for operating the endoprosthesis includes displacing the loop structures toward one another along the filament to displaced positions relative to the suture structure for reducing the respective profiles of the stent structure and patch structure.

Abstract translation: 内假体包括具有细长构件的支架结构，其长度部分重叠以限定交叉结构。 支架结构还可以包括与交叉结构邻接的环结构，细丝延伸穿过该结构。 保护结构被固定到支架结构并且位于交叉结构附近以阻止细丝在交叉结构的细长构件的纵向部分之间的移位。 用于操作内用假体的方法包括将所述环结构相对于所述细丝相互朝向彼此移动以相对于所述缝合线结构移位以减少所述支架结构和贴片结构的相应轮廓。

公开(公告)号：US20120071865A1

公开(公告)日：2012-03-22

申请号：US12884466

申请日：2010-09-17

Applicant: Peter Jarrett ,  Rami El Hayek ,  Michael Bassett ,  James Biggins

Inventor： Peter Jarrett ,  Rami El Hayek ,  Michael Bassett ,  James Biggins

IPC: A61B18/20 ,  A61P27/02 ,  A61P29/00 ,  A61K9/00

CPC classification number: A61K9/0048 ,  A61K9/06 ,  A61K47/34

Abstract: Materials and methods of treating an eye with a hydrogel formed on the eye. Embodiments are provided that include post-keratectomy bandages.

Abstract translation: 用眼睛上形成的水凝胶治疗眼睛的材料和方法。 提供了包括后角膜切除术绷带的实施例。

公开(公告)号：US20070244413A1

公开(公告)日：2007-10-18

申请号：US11403043

申请日：2006-04-12

Applicant: James Biggins

Inventor： James Biggins

IPC: A61M25/00

CPC classification number: A61M25/09 ,  A61M25/0054 ,  A61M2025/09083 ,  A61M2025/09175

Abstract: A medical guidewire having a core-to-tip construction that includes a core wire region surrounded by a flexible coil. The core wire having a distal tip segment that includes a proximal flat drop axially separated from a distal flat drop by a cylindrical or frusto-conical linking portion. The proximal and distal flat drops each having a pair of parallel planar surfaces, wherein the planar surfaces of the proximal flat drop are at an angle to the planar surfaces of the distal flat drop. The tip construction provides improved flexibility while maintaining columnar strength and providing excellent torsional characteristics.

Abstract translation: 一种医疗用导线，其具有芯 - 尖端结构，其包括被柔性线圈围绕的芯线区域。 芯线具有远侧末端段，其包括通过圆柱形或截头圆锥形连接部分从远端平坦液滴轴向分离的近侧平坦液滴。 近端和远端扁平液滴各自具有一对平行的平坦表面，其中近端平坦液滴的平坦表面与远端平坦液滴的平面表面成一角度。 尖端结构提供了改善的灵活性，同时保持柱状强度并提供优异的扭转特性。