公开(公告)号：US20160258910A1

公开(公告)日：2016-09-08

申请号：US14638544

申请日：2015-03-04

Applicant: Jonathan James Grandy ,  German Augusto Gomez-Rios ,  Janusz Boleslaw Pawliszyn

Inventor： Jonathan James Grandy ,  German Augusto Gomez-Rios ,  Janusz Boleslaw Pawliszyn

IPC: G01N30/04 ,  B01J20/281 ,  G01N1/40

CPC classification number: G01N30/04 ,  B01L2300/069 ,  G01N1/405 ,  G01N30/08 ,  G01N30/48 ,  G01N2001/2893 ,  G01N2030/009 ,  G01N2030/045 ,  G01N2030/062 ,  G01N2030/488

Abstract: The invention describes the process by which a standard mixture of organic compounds are spiked and retained onto a composite sorbent matrix for the controlled generation of a standard in fluid above the spiked matrix either in gas (headspace) or aqueous phase which is contained in portable vials. The novelty of the aforementioned composite matrix stems from the combination of an immobilizing liquid phase such as silicone oil or a polyacrylonitrile solution, and solid, porous particles such as polystyrene-co-divinylbenzene (PS-DVB) or Hydrophilic/Lipophilic Balance (HLB) particles to strongly retain the spiked standards facilitating high capacity which translates into prolonged use as a source of calibrant. These novel composite mixtures exhibit sorptive capabilities greater than the sum of their individual components producing a standard analyte generator far superior to those described in the prior art. In addition swelling of the particles with the liquid phase facilitates immobilization of the composite sorbent matrix in the vial. Immobilization of said particles has also been achieved by cross-linking of a liquid polymeric solution such as polydimethylsiloxane (PDMS), allowing the composite sorbent matrix to be uniformly distributed on the vessel wall. With thermodynamic equilibrium strongly favoring the sorbent phase for a wide range of chemical compounds, this invention allows for the reproducible generation of an ultra-low concentration standard analyte mixture in fluid. If the fluid is gaseous, extractions from this headspace can be performed via solid phase microextraction (SPME), needle trap devices (NTD), or direct headspace extraction for injection onto various hyphenated gas chromatography (GC) systems. If the fluid is aqueous, extractions may be performed directly from the standard water for injection onto hyphenated GC or liquid chromatography (LC) systems. The invention can be used for a variety of applications ranging from integrated GC-MS or LC-MS tuning, automated instrument quality control (QC), preparation of reusable external calibration mixtures and, addition of internal standards wherein the method provides long-term stability, inter-batch reproducibility, repeatable analyte loading of the fluid, and quantifiable low concentrations at given temperatures.

公开(公告)号：US20060173932A1

公开(公告)日：2006-08-03

申请号：US11048447

申请日：2005-01-31

Applicant: David Cortright ,  James Grandy ,  Daniel Crevier

Inventor： David Cortright ,  James Grandy ,  Daniel Crevier

IPC: G06F12/00

CPC classification number: G06F17/30569 ,  Y10S707/99943

Abstract: Various entities need to share data among team members working on the same project without investing in specialized server software. To address this need, an existing standard file server is used to host data for sharing among the team. The file server has not been customized to share the data for the particular application. A user creates a special folder for a project at a user specified location on the file server. Data associated with the project is converted to files and stored in a structure of folders used by the file server to represent the data that is shared. Each client that has subscribed to this shared data synchronizes the data on their local computing device with the data on the file server. Security is provided by using the file server's built-in access controls.

Abstract translation: 各个实体需要在同一个项目上工作的团队成员之间共享数据，而无需投入专门的服务器软件。 为了解决这个需要，现有的标准文件服务器用于托管数据以便在团队之间进行共享。 文件服务器尚未被自定义以共享特定应用程序的数据。 用户在文件服务器上的用户指定位置为项目创建一个特殊文件夹。 与项目关联的数据将转换为文件，并存储在文件服务器使用的文件夹结构中，以表示共享的数据。 已订阅此共享数据的每个客户端将本地计算设备上的数据与文件服务器上的数据进行同步。 使用文件服务器的内置访问控制来提供安全性。

公开(公告)号：US20060047811A1

公开(公告)日：2006-03-02

申请号：US10932569

申请日：2004-09-01

Applicant: Daniel Lau ,  Daniel Crevier ,  Jorge Morinigo ,  Robert Vreeland ,  Shengyong Li ,  Stuart DeSpain ,  Brooke Nelson ,  Jeffrey Smith ,  James Grandy ,  Laura Neumann ,  Tony Lin ,  Vianna Tam

Inventor： Daniel Lau ,  Daniel Crevier ,  Jorge Morinigo ,  Robert Vreeland ,  Shengyong Li ,  Stuart DeSpain ,  Brooke Nelson ,  Jeffrey Smith ,  James Grandy ,  Laura Neumann ,  Tony Lin ,  Vianna Tam

IPC: G06F15/173

CPC classification number: H04L67/2852 ,  H04L51/16

Abstract: Described is a system and method that enables project management across application programs, including an email program, calendar program, spreadsheet program, word processing program, note taking program and others. A central project-related view provides access to project-related data items and may display a schedule, a task list of tasks filtered as being relevant to a project, a note page related to a project, and emails relevant to the project. In addition, other application objects (file, documents, presentations and spreadsheets) are also captured in the view and presented for easy access. Metadata including a project identifier is maintained in a database for the various data items, allowing rapid location of the data items related to a project via query techniques. A project palette allows access to the items from within another application program, and a project gallery allows a user alternative access to the files related to a project.

Abstract translation: 描述了一种能够跨应用程序进行项目管理的系统和方法，包括电子邮件程序，日历程序，电子表格程序，文字处理程序，记录程序等。 中央项目相关视图提供对项目相关数据项的访问，并且可以显示计划，过滤为与项目相关的任务的任务列表，与项目相关的注释页面以及与项目相关的电子邮件。 此外，其他应用对象（文件，文档，演示文稿和电子表格）也被捕获在视图中并被呈现以便于访问。 包含项目标识符的元数据被保存在用于各种数据项的数据库中，允许通过查询技术快速定位与项目相关的数据项。 项目调色板允许访问另一个应用程序中的项目，项目库允许用户对与项目相关的文件进行替代访问。

公开(公告)号：US09625426B2

公开(公告)日：2017-04-18

申请号：US14638544

申请日：2015-03-04

Applicant: Janusz Boleslaw Pawliszyn ,  Jonathan James Grandy ,  German Augusto Gomez Rios

Inventor： Janusz Boleslaw Pawliszyn ,  Jonathan James Grandy ,  German Augusto Gomez Rios

IPC: B01J20/281 ,  G01N1/40 ,  G01N30/04 ,  B01D15/10 ,  G01N30/00 ,  G01N30/06 ,  G01N1/28

CPC classification number: G01N30/04 ,  B01L2300/069 ,  G01N1/405 ,  G01N30/08 ,  G01N30/48 ,  G01N2001/2893 ,  G01N2030/009 ,  G01N2030/045 ,  G01N2030/062 ,  G01N2030/488

Abstract: The invention describes the process by which a standard mixture of organic compounds are spiked and retained onto a composite sorbent matrix for the controlled generation of a standard in fluid above the spiked matrix either in a gaseous or aqueous phase. The novelty of the aforementioned composite matrix stems from the combination of an immobilizing liquid phase such as silicone oil or a polyacrylonitrile solution, and solid, porous particles such as polystyrene-co-divinylbenzene (PS-DVB) or hydrophilic/Lipophilic Balance (HLB) particles to strongly retain the spiked standards. These novel composite mixtures exhibit sorptive capabilities greater than the sum of their individual components. In addition swelling of the particles with the liquid phase facilitates immobilization of the composite sorbent matrix in the vial. With thermodynamic equilibrium strongly favoring the sorbent phase for a wide range of chemical compounds, this invention allows for the reproducible generation of an ultra-low concentration standard analyte mixture in fluid.