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1.发明授权公开(公告)号：US06291237B1
公开(公告)日：2001-09-18
申请号：US09239864
申请日：1999-01-29
IPC分类号： C12N121
CPC分类号： G01N33/57492 , A61K38/00 , A61K48/00 , C07K14/71 , Y02A90/26 , Y10S436/811
摘要： This invention is based on the discovery that the type II TGF&bgr; receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis.
摘要翻译： 本发明基于以下发现：II型TGFbeta受体（RII）是在约25％的结肠癌中被遗传灭活（突变）的癌抑制基因，其包括几乎所有被称为变异体/微卫星不稳定性的结肠癌 / RER。 提供了用于检测用于癌症诊断或预后的RII的失活的方法。
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公开(公告)号：US06630326B2
公开(公告)日：2003-10-07
申请号：US09878905
申请日：2001-06-13
IPC分类号： C12N1563
CPC分类号： G01N33/57492 , A61K38/00 , A61K48/00 , C07K14/71 , Y02A90/26 , Y10S436/811
摘要： This invention is based on the discovery that the type II TGF&bgr; receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis.
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3.发明授权Spring guide wire with torque control for catheterization of blood vessels and method of using same 失效具有扭矩控制用于血管导管的弹簧导丝及其使用方法
公开(公告)号：US4020829A
公开(公告)日：1977-05-03
申请号：US625073
申请日：1975-10-23
CPC分类号： A61M25/09 , A61M2025/09066 , A61M2025/09191
摘要： An instrument for use in catheterization of small distal branch arteries includes a guide wire having a short flexible distal section connected with a relatively long, multi-wire, axial and rotary torque transmitting section to guide a soft, thin-walled, flexible catheter through the compound curves involved in the junctions between various arterial branches. A method for catheterization of blood vessels includes the steps of sequentially advancing the catheter and guide wire to negotiate these compound turns in the arterial system.
摘要翻译： 用于小远端分支动脉导管插入的仪器包括导丝，其具有与较长的多线，轴向和旋转扭矩传递部分连接的短柔性远端部分，以引导柔软的薄壁柔性导管通过 涉及各种动脉分支之间的交界处的复合曲线。 用于导管血管的方法包括依次推进导管和导丝以协商动脉系统中的这些复合匝的步骤。
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4.发明授权
公开(公告)号：US5866323A
公开(公告)日：1999-02-02
申请号：US445520
申请日：1995-05-22
IPC分类号： G01N33/50 , A61K35/74 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/71 , C07K16/30 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/574 , C12N15/00 , G01N33/567
CPC分类号： G01N33/57492 , C07K14/71 , A61K38/00 , A61K48/00 , Y10S436/811
摘要： This invention is based on the discovery that the type II TGF-.beta. receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis.
摘要翻译： 本发明基于以下发现：II型TGF-β受体（RII）是在大约25％的结肠癌中被遗传灭活（突变）的癌抑制基因，包括几乎所有类别的所有结肠癌被鉴定为变异体/ 微卫星不稳定/ RER。 提供了用于检测用于癌症诊断或预后的RII的失活的方法。
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公开(公告)号：US4215703A
公开(公告)日：1980-08-05
申请号：US937775
申请日：1978-08-29
申请人： James K. V. Willson
发明人： James K. V. Willson
CPC分类号： A61M25/09033 , A61M2025/0915
摘要： A guide wire capable of being adjusted to provide variable stiffness for catheterizing arterial branches comprises an elongated helical wire coil with a plurality of core wires contained within and joined to the outer wire coil at their distal ends; at their proximal ends there is a handle having two elements which are movable relative to each other connected respectively to the inner core wires and to the wire coil to vary the extent to which the coil may be flexed, by tensioning the core wires and limiting the longitudinal expansion of the coil.
摘要翻译： 能够被调节以提供用于导管动脉分支的可变刚度的导丝包括细长的螺旋线圈，其多根芯线包含在其远端处并且连接到外线圈上; 在其近端处具有手柄，其具有两个元件，该元件可相对于彼此分别连接，分别连接到内芯线和线圈，以通过张紧芯线来改变线圈可弯曲的程度，并限制 线圈的纵向膨胀。
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