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公开(公告)号：US06842704B2
公开(公告)日：2005-01-11
申请号：US09244984
申请日：1999-02-04
申请人： Roy A. Black , Raymond James Paxton , Wolfram Bode , Klaus Maskos , Carlos Fernandez-Catalan , James Ming Chen , Jeremy Ian Levin
发明人： Roy A. Black , Raymond James Paxton , Wolfram Bode , Klaus Maskos , Carlos Fernandez-Catalan , James Ming Chen , Jeremy Ian Levin
CPC分类号： C12N9/6489
摘要： A tumor necrosis factor-α converting enzyme (TACE) is produced, purified, and crystallized. The three-dimensional coordinates of the crystal are obtained by X-ray diffraction. The coordinates can be recorded on a computer readable medium, or are part of a video memory, where they can be used as part of a system for studying for studying TACE. The coordinates are also used in designing, screening, and developing compounds that associate with TACE.
摘要翻译： 产生，纯化和结晶的肿瘤坏死因子-α转化酶（TACE）。 通过X射线衍射获得晶体的三维坐标。 坐标可以被记录在计算机可读介质上，或者是视频存储器的一部分，它们可以用作用于研究TACE的系统的一部分。 坐标也用于设计，筛选和开发与TACE相关的化合物。
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2.发明授权Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors 失效邻氨基磺酰氨基芳基异羟肟酸作为基质金属蛋白酶抑制剂的制备和应用公开(公告)号：US07470794B2
公开(公告)日：2008-12-30
申请号：US10980990
申请日：2004-11-04
IPC分类号： C07D263/02
CPC分类号： C07D307/87 , C07D307/78 , C07D333/52
摘要： Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.
摘要翻译： 提供了邻磺酰氨基芳基异羟肟酸，其尤其可用于抑制基质金属蛋白酶和治疗与MMP过量表达相关的病症。
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3.发明授权Preparation and use of ortho-sulfonamido arylhydroxamic acids as matrix metalloproteinase inhibitors 失效邻氨基磺酰氨基芳基肟酸作为基质金属蛋白酶抑制剂的制备和应用公开(公告)号：US06825352B2
公开(公告)日：2004-11-30
申请号：US10231584
申请日：2002-08-30
IPC分类号： C07D21516
CPC分类号： C07D307/87 , C07D307/78 , C07D333/52
摘要： Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.
摘要翻译： 提供了正亚磺酰氨基芳基异羟肟酸，其尤其可用于抑制基质金属蛋白酶和治疗与MMP的过度表达相关的病症。
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4.发明授权Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors 失效邻氨基磺酰氨基芳基异羟肟酸作为基质金属蛋白酶抑制剂的制备和应用公开(公告)号：US06465508B1
公开(公告)日：2002-10-15
申请号：US09792798
申请日：2001-02-23
IPC分类号： A61K3138
CPC分类号： C07D307/87 , C07D307/78 , C07D333/52
摘要： Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.
摘要翻译： 提供了正亚磺酰氨基芳基异羟肟酸，其尤其可用于抑制基质金属蛋白酶和治疗与MMP的过度表达相关的病症。
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5.发明授权公开(公告)号：US06544984B1
公开(公告)日：2003-04-08
申请号：US09492622
申请日：2000-01-27
IPC分类号： A61K3155
CPC分类号： C07D401/06 , C07D243/14 , C07D409/06
摘要： Compounds having the following formula: are useful in treating disease conditions mediated by matrix metalloproteinases and TACE, such as tumor growth, osteoarthritis, rheumatoid arthritis and degenerative cartilage loss.
摘要翻译： 具有下式的化合物可用于治疗由基质金属蛋白酶和TACE介导的疾病状况，例如肿瘤生长，骨关节炎，类风湿性关节炎和退行性软骨损失。
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