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1.发明申请公开(公告)号：US20140154232A1
公开(公告)日：2014-06-05
申请号：US13880893
申请日：2011-06-01
申请人： Manuel Serrano Marugan , Joaquin Pastor Fernández , Sonia Martínez González , Ana Ortega Molina , James R. Bischoff , Julen Oyarzabal Santamarina
发明人： Manuel Serrano Marugan , Joaquin Pastor Fernández , Sonia Martínez González , Ana Ortega Molina , James R. Bischoff , Julen Oyarzabal Santamarina
IPC分类号： A61K31/5377 , C07D471/10 , A61K45/06 , C07D487/04
CPC分类号： A61K45/06 , A61K31/35 , A61K31/4985 , A61K31/5377 , C07D471/10 , C07D487/04
摘要： The first aspect of the invention relates to a phosphoinositide 3-kinase inhibitor for use in the treatment or prevention of a disease or condition associated with the expression of peroxisome proliferator-activated receptor gamma coactivator 1-α (Pgd1α) and/or uncoupling protein 1 (Thermogenin/Ucp1) in brown adipocytes. The disease or condition may be positive energy imbalance-associated, for example, obesity, an obesity-associated disease or condition, steatosis and biological aging (performance aging). Another aspect of the invention provides the use of a phosphoinositide 3-kinase inhibitor for promoting weight loss in an individual.
摘要翻译： 本发明的第一方面涉及用于治疗或预防与过氧化物酶体增殖物激活受体γ共激活因子1-α（Pgd1α）和/或解偶联蛋白1的表达相关的疾病或病症的磷酸肌醇3-激酶抑制剂 （Thermogenin / Ucp1）在棕色脂肪细胞。 疾病或病症可能是正能量失衡相关的，例如肥胖，肥胖相关疾病或病症，脂肪变性和生物衰老（性能衰老）。 本发明的另一方面提供了磷酸肌醇3-激酶抑制剂在个体中促进体重减轻的用途。
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公开(公告)号：US5756669A
公开(公告)日：1998-05-26
申请号：US399696
申请日：1995-03-02
申请人： James R. Bischoff , Lelia Wu
发明人： James R. Bischoff , Lelia Wu
IPC分类号： G01N33/566 , A61K31/70 , A61K38/00 , A61K49/00 , A61P1/16 , A61P9/08 , A61P9/10 , A61P25/00 , A61P31/12 , A61P35/00 , C07H21/04 , C07K14/47 , C07K14/82 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , G01N33/50 , G01N33/574 , C12N15/64
CPC分类号： G01N33/5011 , C07K14/47 , C07K14/82 , G01N33/57496 , A61K38/00 , G01N2333/47 , G01N2333/4703
摘要： The invention provides mammalian polypeptides which bind wild-type and/or mutant mamalian p53 proteins, polynucleotides encoding such polypeptides, screening assays for drug development employing such polypeptides and polynucleotides, immunological and other reagents for diagnostic, therapeutic, and research applications.
摘要翻译： 本发明提供了结合野生型和/或突变型mamalian p53蛋白质的哺乳动物多肽，编码这种多肽的多核苷酸，筛选使用这种多肽和多核苷酸的药物开发的测定法，用于诊断，治疗和研究应用的免疫学和其它试剂。
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公开(公告)号：US5705342A
公开(公告)日：1998-01-06
申请号：US484945
申请日：1995-06-07
CPC分类号： C07K14/82 , C07K14/4702 , A61K38/00
摘要： The invention provides compositions and methods for screening for agents which are modulators of bcl-2 function and can modulate bcl-2-mediated apoptosis and/or modulate neoplastic and immune conditions dependent upon bcl-2 function. The invention also provides a composition comprising a substantially pure protein complex comprising a R-ras polypeptide and a bcl-2 polypeptide.
摘要翻译： 本发明提供用于筛选作为bcl-2功能的调节剂并可以调节bcl-2介导的细胞凋亡和/或调节依赖于bcl-2功能的肿瘤和免疫病症的药剂的组合物和方法。 本发明还提供包含基本上纯的包含R-ras多肽和bcl-2多肽的蛋白质复合物的组合物。
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公开(公告)号：US09993554B2
公开(公告)日：2018-06-12
申请号：US13880893
申请日：2011-06-01
申请人： Manuel Serrano Marugan , Joaquin Pastor Fernández , Sonia Martínez González , Ana Ortega Molina , James R. Bischoff , Julen Oyarzabal Santamarina
发明人： Manuel Serrano Marugan , Joaquin Pastor Fernández , Sonia Martínez González , Ana Ortega Molina , James R. Bischoff , Julen Oyarzabal Santamarina
IPC分类号： A61K31/5377 , A61K31/35 , A61K45/06 , C07D471/10 , C07D487/04 , A61K31/4985
CPC分类号： A61K45/06 , A61K31/35 , A61K31/4985 , A61K31/5377 , C07D471/10 , C07D487/04
摘要： The first aspect of the invention relates to a phosphoinositide 3-kinase inhibitor for use in the treatment or prevention of a disease or condition associated with the expression of peroxisome proliferator-activated receptor gamma coactivator 1-α (Pgd1α) and/or uncoupling protein 1 (Thermogenin/Ucp1) in brown adipocytes. The disease or condition may be positive energy imbalance-associated, for example, obesity, an obesity-associated disease or condition, steatosis and biological aging (performance aging). Another aspect of the invention provides the use of a phosphoinositide 3-kinase inhibitor for promoting weight loss in an individual.
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5.发明授权Cytopathic adenoviral E1B mutated viruses for therapy and prophylaxis of neoplasia 失效细胞病变腺病毒E1B突变病毒用于治疗和预防肿瘤
公开(公告)号：US6080578A
公开(公告)日：2000-06-27
申请号：US986331
申请日：1997-12-08
申请人： James R. Bischoff , Julie Nye , Lelia Ng , Sharon Horn , Angelica Williams , David Kirn
发明人： James R. Bischoff , Julie Nye , Lelia Ng , Sharon Horn , Angelica Williams , David Kirn
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/075 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/04 , C12N15/861 , C12R1/93 , C07H21/04
CPC分类号： C07K14/005 , C12N15/86 , C12N7/00 , A61K38/00 , A61K48/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10362
摘要： Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 and/or RB function. The mutant virus is able to substantially produce a replication phenotype in neoplastic cells but is substantially unable to produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 and/or RB function. The preferential generation of replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype.
摘要翻译： 提供了通过病毒治疗来治疗肿瘤病症的方法和组合物。 将具有结合和/或失活p53或RB的病毒蛋白的突变病毒给予具有肿瘤的患者，所述肿瘤包含缺乏p53和/或RB功能的细胞。 突变型病毒能够在肿瘤细胞中基本上产生复制表型，但基本上不能在具有基本正常p53和/或RB功能的非复制性非肿瘤细胞中产生复制表型。 在肿瘤细胞中优先产生复制表型导致直接或通过在表达病毒复制表型的细胞中表达细胞毒性基因来赘生性细胞的优先杀伤。
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公开(公告)号：US5539085A
公开(公告)日：1996-07-23
申请号：US110287
申请日：1993-08-20
IPC分类号： A61K38/00 , C07K14/47 , C07K14/82 , C07K14/435
CPC分类号： C07K14/82 , C07K14/4702 , A61K38/00
摘要： The invention provides compositions and methods for screening for agents which are modulators of bcl-2 function and can modulate bcl-2-mediated apoptosis and/or modulate neoplastic and immune conditions dependent upon bcl-2 function. The invention also provides a composition comprising a substantially pure protein complex comprising a R-ras polypeptide and a bcl-2 polypeptide.
摘要翻译： 本发明提供用于筛选作为bcl-2功能的调节剂并可以调节bcl-2介导的细胞凋亡和/或调节依赖于bcl-2功能的肿瘤和免疫病症的药剂的组合物和方法。 本发明还提供包含基本上纯的包含R-ras多肽和bcl-2多肽的蛋白质复合物的组合物。
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公开(公告)号：US5360957A
公开(公告)日：1994-11-01
申请号：US896933
申请日：1992-06-11
摘要： A controlled EDM apparatus comprises at least one electrode mounted in a base, a driver for positioning the base, a system for providing electrical energy to the electrode, a monitor for measuring the electrical discharge frequency of the electrode, and a controller responsive to the monitor for controlling either the driver or the energy providing system. The apparatus operates by measuring the electrical discharge frequency of the electrode and controlling at least the duration of machining in accordance with the frequency measured.
摘要翻译： 受控电火花加工设备包括安装在基座中的至少一个电极，用于定位基座的驱动器，用于向电极提供电能的系统，用于测量电极的放电频率的监视器以及响应于监视器的控制器 用于控制驾驶员或能量提供系统。 该装置通过测量电极的放电频率并根据测量的频率至少控制加工的持续时间来操作。
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