公开(公告)号：US4631337A

公开(公告)日：1986-12-23

申请号：US755259

申请日：1985-07-15

Applicant: Donald A. Tomalia ,  James R. Dewald

Inventor： Donald A. Tomalia ,  James R. Dewald

IPC: A61K47/48 ,  B01D17/04 ,  C08G69/44 ,  C08G69/48 ,  C08G73/02 ,  C08G83/00 ,  C09D7/00 ,  C09D201/00 ,  C10G33/04 ,  C08G73/00

CPC classification number: C08G83/003 ,  A61K47/48192 ,  B01D17/047 ,  C08G69/44 ,  C08G69/48 ,  C08G73/028 ,  C09D201/005 ,  C09D7/002 ,  C10G33/04 ,  C08L101/005 ,  C08L79/02 ,  Y10S424/16

Abstract: Dense star polyamines having terminal group densities greater than extended conventional star polyamines exhibit greater and more uniform reactivity than their corresponding extended conventional star polyamines. For example, a second generation, amine-terminated polyamine dense star polyamine prepared from tri(2-aminoethyl)amine and aziridine has 4.7.times.10.sup.-3 amine moieties per unit volume (cubic Angstrom units) in contrast to the 1.7.times.10.sup.-3 amine moieties per unit volume contained by an extended conventional star polyamine. Such dense star polyamines are useful as calibration standards, high efficiency proton scavengers and in making size selective membranes.

Abstract translation: 具有大于扩展的常规星形多胺的末端基团密度的密集聚胺表现出比其相应的扩展的常规星形多胺更大和更均匀的反应性。 例如，与1.7×10-3胺部分相比，由三（2-氨基乙基）胺和氮丙啶制备的第二代胺封端的多胺致密星状多胺与单位体积（立方单位）相比具有4.7×10-3个胺部分 由扩展的常规星形多胺包含的每单位体积。 这种致密的星形多胺可用作校准标准品，高效质子清除剂和制备尺寸选择性膜。

公开(公告)号：US4059642A

公开(公告)日：1977-11-22

申请号：US707924

申请日：1976-07-22

Applicant: James R. Dewald ,  Lowell D. Markley

Inventor： James R. Dewald ,  Lowell D. Markley

IPC: C07C17/26 ,  C07C17/395 ,  C07C25/08

CPC classification number: C07C17/269

Abstract: In a mixture of isomers of a disubstituted benzene such as dichlorobenzene, the meta-disubstituted isomer is preferentially reacted with an alkylating or acylating agent, e.g., an alkyl halide, by contacting the mixture with the agent in the presence of a Friedel-Craft catalyst at a temperature of less than about 60.degree. C.The resulting alkylated or acylated meta-isomer can be readily separated from the reaction mixture by simple distillation.

Abstract translation: 在二取代苯如二氯苯的异构体的混合物中，间二取代的异构体优选与烷基化或酰化剂例如烷基卤反应，通过在Friedel-Craft催化剂存在下使该混合物与试剂接触 在小于约60℃的温度下

公开(公告)号：US4104315A

公开(公告)日：1978-08-01

申请号：US776168

申请日：1977-03-10

Applicant: James R. Dewald ,  Lowell D. Markley

Inventor： James R. Dewald ,  Lowell D. Markley

IPC: C07C17/26 ,  C07C17/395 ,  C07C25/04

CPC classification number: C07C17/269

Abstract: In a mixture of isomers of ar,ar-dihalo-ar-alkylbenzene wherein the halogen substituents are meta oriented with respect to each other, (e.g., a mixture of 3,5-dichlorocumene and 2,4-dichlorocumene), the 2,4-dihalo-1-alkylbenzene is preferentially reacted with an alkylating agent, e.g., an alkyl halide, by contacting the mixture with the agent in the presence of a Friedel-Crafts catalyst at a temperature of less than about 90.degree. C. The resulting alkylated isomer is readily separated from the unreacted isomer(s) by simple distillation.

Abstract translation: 在其中卤素取代基相对于彼此间位取向的（ar-二卤代 - 芳烷基苯）的异构体的混合物中（例如，3,5-二氯绒毛烯和2,4-二氯苯甲酸的混合物） 4-二卤代-1-烷基苯优选与烷基化剂例如烷基卤反应，通过在Friedel-Crafts催化剂存在下，在低于约90℃的温度下使该混合物与该试剂接触。所得到的 烷基化异构体通过简单蒸馏容易地与未反应的异构体分离。

公开(公告)号：US4507466A

公开(公告)日：1985-03-26

申请号：US456226

申请日：1983-01-07

Applicant: Donald A. Tomalia ,  James R. Dewald

Inventor： Donald A. Tomalia ,  James R. Dewald

IPC: C08G69/02 ,  A61K47/48 ,  B01D17/04 ,  C07C231/02 ,  C07C231/12 ,  C07C233/78 ,  C07C237/10 ,  C08G63/02 ,  C08G65/28 ,  C08G65/38 ,  C08G69/00 ,  C08G69/44 ,  C08G69/48 ,  C08G73/00 ,  C08G73/02 ,  C08G75/00 ,  C08G75/02 ,  C08G75/20 ,  C08G83/00 ,  C08G85/00 ,  C09D7/00 ,  C09D201/00 ,  C10G33/04

CPC classification number: C07C233/78 ,  A61K47/48192 ,  A61K47/482 ,  A61K47/48207 ,  B01D17/047 ,  C07C237/10 ,  C08G69/44 ,  C08G69/48 ,  C08G73/028 ,  C08G83/003 ,  C09D201/005 ,  C09D7/002 ,  C10G33/04 ,  C08L101/005 ,  Y10S424/16

Abstract: Dense star polymers having terminal group densities greater than conventional star polymers exhibit greater and more uniform reactivity than their corresponding conventional star polymers. For example, a third generation, amine-terminated polyamidoamine dense star polymer prepared from ammonia, methyl acrylate and ethylenediamine has 1.24.times.10.sup.-4 amine moieties per unit volume (cubic Angstrom units) in contrast to the 1.58.times.10.sup.-6 amine moieties per unit volume contained by a conventional star polymer. Such dense star polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, and agents for modifying viscosity in aqueous formulations such as paints.

Abstract translation: 具有大于常规星形聚合物的端基密度的密集聚合物表现出比其相应的常规星形聚合物更大且更均匀的反应性。 例如，由氨，丙烯酸甲酯和乙二胺制备的第三代胺封端的聚酰胺胺致密星形聚合物与每单位体积的1.58x10-6胺部分相比，每单位体积（立方单位）具有1.24×10-4胺部分 由常规的星形聚合物包含。 这种致密的星形聚合物可用作油/水乳液的破乳剂，纸张制造中的湿强力剂和用于改进水性配方如油漆中的粘度的试剂。

公开(公告)号：US4886922A

公开(公告)日：1989-12-12

申请号：US650915

申请日：1984-09-14

Applicant: Dennis K. Klipa ,  James R. Dewald

Inventor： Dennis K. Klipa ,  James R. Dewald

IPC: B01J21/04 ,  C07C17/25

CPC classification number: C07C17/25 ,  B01J21/04 ,  C07C17/278

Abstract: A method for preparing an .alpha.-substituted styrene such as 2-(3,5-dichlorophenyl)-4,4,4-trichloro-1-butene comprising contacting, an .alpha.-haloalkylbenzene such as 3-(3,5-dichlorophenyl)-1,1,1,3-tetrachlorobutane with a catalyst consisting essentially of .gamma.-alumina dried to a moisture content between about zero to about 12% by weight, the .gamma.-alumina serving to catalyze the dehydrohalogenation of the .alpha.-haloalkylbenzene to produce the .alpha.-substituted styrene.

Abstract translation: 一种制备α-取代苯乙烯如2-（3,5-二氯苯基）-4,4,4-三氯-1-丁烯的方法，包括使α-卤代烷基苯如3-（3,5-二氯苯基） -1,1,1,3-四氯丁烷与基本上由γ-氧化铝组成的催化剂干燥至水分含量在约0至约12重量％之间，γ-氧化铝用于催化α-卤代烷基苯的脱卤化氢以产生 α-取代苯乙烯。

公开(公告)号：US4558120A

公开(公告)日：1985-12-10

申请号：US565686

申请日：1983-12-27

Applicant: Donald A. Tomalia ,  James R. Dewald

Inventor： Donald A. Tomalia ,  James R. Dewald

IPC: A61K47/48 ,  B01D17/04 ,  C08G69/44 ,  C08G69/48 ,  C08G73/02 ,  C08G83/00 ,  C09D7/00 ,  C09D201/00 ,  C10G33/04 ,  C08G69/00

CPC classification number: C08G83/003 ,  A61K47/48192 ,  A61K47/482 ,  A61K47/48207 ,  B01D17/047 ,  C08G69/44 ,  C08G69/48 ,  C08G73/028 ,  C09D201/005 ,  C09D7/002 ,  C10G33/04 ,  C08L101/005 ,  Y10S424/16

Abstract: Dense star polymers having terminal group densities greater than conventional star polymers exhibit greater and more uniform reactivity than their corresponding conventional star polymers. For example, a third generation, amine-terminated polyamidoamine dense star polymer prepared from ammonia, methyl acrylate and ethylenediamine has 1.24.times.10.sup.-4 amine moieties per unit volume (cubic Angstrom units) in contrast to the 1.58.times.10.sup.-6 amine moieties per unit volume contained by a conventional star polymer. Such dense star polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, and agents for modifying viscosity in aqueous formulations such as paints.

Abstract translation: 具有大于常规星形聚合物的端基密度的密集聚合物表现出比其相应的常规星形聚合物更大且更均匀的反应性。 例如，由氨，丙烯酸甲酯和乙二胺制备的第三代胺封端的聚酰胺胺致密星形聚合物与每单位体积的1.58x10-6胺部分相比，每单位体积（立方单位）具有1.24×10-4胺部分 由常规的星形聚合物包含。 这种致密的星形聚合物可用作油/水乳液的破乳剂，纸张制造中的湿强力剂和用于改进水性配方如油漆中的粘度的试剂。

公开(公告)号：US4329524A

公开(公告)日：1982-05-11

申请号：US129514

申请日：1980-03-12

Applicant: James R. Dewald

Inventor： James R. Dewald

IPC: C07C17/395 ,  C07C17/38

CPC classification number: C07C17/395

Abstract: 3,5-Dichlorocumene is separated from a mixture comprising 3,5-dichlorocumene and 2,4-dichlorocumene by a process comprising contacting the mixture with an isopropyl group acceptor, in the presence of a catalyst comprising:(1) at least one Lewis acid compound, and(2) a proton source.The isopropyl group of 2,4-dichlorocumene is preferentially transferred, as compared to the isopropyl group of 3,5-dichlorocumene, to the acceptor forming a reaction product comprising an acceptor bearing the isopropyl group, 3,5-dichlorocumene and m-dichlorobenzene. 3,5-Dichlorocumene is readily separated from this reaction product by any conventional technique, typically distillation.

Abstract translation: 通过包括使该混合物与异丙基受体在催化剂的存在下接触的方法从3,5-二氯绒毛烯和2,4-二氯二茂酚的混合物中分离出3,5-二氯庚烯，所述催化剂包含：（1）至少一种路易斯 酸化合物，和（2）质子源。

公开(公告)号：US4587329A

公开(公告)日：1986-05-06

申请号：US757546

申请日：1985-07-19

Applicant: Donald A. Tomalia ,  James R. Dewald

Inventor： Donald A. Tomalia ,  James R. Dewald

IPC: A61K47/48 ,  B01D17/04 ,  C08G69/44 ,  C08G73/02 ,  C09D7/00 ,  C10G33/04 ,  C08G69/00

CPC classification number: A61K47/48207 ,  A61K47/48192 ,  A61K47/482 ,  B01D17/047 ,  C08G69/44 ,  C08G73/028 ,  C09D7/002 ,  C10G33/04 ,  C08L101/005 ,  Y10S424/16

Abstract: Dense star polymers having terminal group densities greater than conventional extended star polymers exhibit greater and more uniform reactivity than their corresponding conventional star polymers. For example, a third generation, hydroxy-terminated polyether dense star polymer can be prepared from pentaerythrityltetrabromide and 4-hydroxymethyl-2,6,7-trioxabicyclo[2.2.2]-octane which has a molecular volume less than 80 percent of the volume of a conventional extended star polymer made from similar materials. Such dense star polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, calibration standards for electron microscopy, and agents for modifying viscosity in aqueous formulations such as paints.

Abstract translation: 具有大于常规延伸的星形聚合物的端基密度的密集聚合物表现出比其相应的常规星形聚合物更大且更均匀的反应性。 例如，第三代羟基封端的聚醚致密星形聚合物可以由季戊四醇四溴化物和4-羟甲基-2,6,7-三氧杂双环[2.2.2] - 辛烷制备，其分子量小于体积的80％ 由类似材料制成的常规的扩展星形聚合物。 这样的致密星形聚合物可用作油/水乳液的破乳剂，纸张制造中的湿强剂，质子清除剂，用于电子显微镜的校准标准品和用于改进水性配方如油漆中的粘度的试剂。

公开(公告)号：US4568737A

公开(公告)日：1986-02-04

申请号：US641807

申请日：1984-08-17

Applicant: Donald A. Tomalia ,  James R. Dewald

Inventor： Donald A. Tomalia ,  James R. Dewald

IPC: A61K47/48 ,  B01D17/04 ,  C08G69/44 ,  C08G69/48 ,  C08G73/02 ,  C08G83/00 ,  C09D7/00 ,  C09D201/00 ,  C10G33/04 ,  C08G69/00

CPC classification number: C08G83/003 ,  A61K47/48192 ,  A61K47/482 ,  A61K47/48207 ,  B01D17/047 ,  C08G69/44 ,  C08G69/48 ,  C08G73/028 ,  C09D201/005 ,  C09D7/002 ,  C10G33/04 ,  C08L101/005 ,  Y10S424/16

Abstract: Dense star polymers having terminal group densities greater than conventional star polymers exhibit greater and more uniform reactivity than their corresponding conventional star polymers. For example, a third generation, amine-terminated polyamidoamine dense star polymer prepared from ammonia, methyl acrylate and ethylenediamine has 1.24.times.10.sup.-4 amine moieties per unit volume (cubic Angstrom units) in contrast to the 1.58.times.10.sup.-6 amine moieties per unit volume contained by a conventional star polymer. Such dense star polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, and agents for modifying viscosity in aqueous formulations such as paints.

Abstract translation: 具有大于常规星形聚合物的端基密度的密集聚合物表现出比其相应的常规星形聚合物更大且更均匀的反应性。 例如，由氨，丙烯酸甲酯和乙二胺制备的第三代胺封端的聚酰胺胺致密星形聚合物与每单位体积的1.58x10-6胺部分相比，每单位体积（立方单位）具有1.24×10-4胺部分 由常规的星形聚合物包含。 这种致密的星形聚合物可用作油/水乳液的破乳剂，纸张制造中的湿强力剂和用于改进水性配方如油漆中的粘度的试剂。