公开(公告)号：US07994168B2

公开(公告)日：2011-08-09

申请号：US11677067

申请日：2007-02-21

Applicant: Petra Lennig ,  Siegfried Stengelin ,  Thomas Klabunde ,  Matthias Gossel ,  Pavel Safar ,  James Spoonamore ,  Gregory Merriman ,  Joseph T Klein ,  Brian Whiteley ,  Carolina Lanter ,  Kenneth Bordeau ,  Zhaoxia Yang ,  Martin Smrcina

Inventor： Petra Lennig ,  Siegfried Stengelin ,  Thomas Klabunde ,  Matthias Gossel ,  Pavel Safar ,  James Spoonamore ,  Gregory Merriman ,  Joseph T Klein ,  Brian Whiteley ,  Carolina Lanter ,  Kenneth Bordeau ,  Zhaoxia Yang ,  Martin Smrcina

IPC: C07D487/04 ,  A61K31/4985 ,  A61P3/04

CPC classification number: C07D487/04

Abstract: The invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives substituted with amino acids, and to the physiologically tolerated salts thereof, processes for their preparation and their use as medicaments.

Abstract translation: 本发明涉及被氨基酸取代的取代六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物及其生理学上可耐受的盐，其制备方法及其用作药物。

公开(公告)号：US07750005B2

公开(公告)日：2010-07-06

申请号：US12124503

申请日：2008-05-21

Applicant: Stefanie Flohr ,  Siegfried Stengelin ,  Matthias Gossel ,  Thomas Klabunde ,  Pavel Safar ,  James Spoonamore ,  Martin Smrcina

Inventor： Stefanie Flohr ,  Siegfried Stengelin ,  Matthias Gossel ,  Thomas Klabunde ,  Pavel Safar ,  James Spoonamore ,  Martin Smrcina

IPC: C07D487/00 ,  A61K31/495 ,  A01N43/60

CPC classification number: C07D487/04

Abstract: The invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof.Compounds of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example as anorectic agents.

Abstract translation: 本发明涉及取代的六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物及其生理上耐受的盐和生理功能衍生物。 描述了其中基团具有所述含义的式I化合物及其生理上耐受的盐及其制备方法。 该化合物适合于例如厌食剂。

公开(公告)号：US07652007B2

公开(公告)日：2010-01-26

申请号：US10779439

申请日：2004-02-13

Applicant: Stefanie Flohr ,  Siegfried Stengelin ,  Matthias Gossel ,  Thomas Klabunde ,  Petra Stahl ,  Pavel Safar ,  James Spoonamore ,  Martin Smrcina ,  Joseph Klein ,  Gregory Merriman ,  Brian Whiteley ,  Carolina Lanter ,  Kenneth Bordeau ,  Zhaoxia Yang

Inventor： Stefanie Flohr ,  Siegfried Stengelin ,  Matthias Gossel ,  Thomas Klabunde ,  Petra Stahl ,  Pavel Safar ,  James Spoonamore ,  Martin Smrcina ,  Joseph Klein ,  Gregory Merriman ,  Brian Whiteley ,  Carolina Lanter ,  Kenneth Bordeau ,  Zhaoxia Yang

IPC: C07D487/00 ,  A61K31/495 ,  A01N43/60

CPC classification number: C07D487/04

Abstract: Nitrogen-substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives, processes for the preparation and their use as medicamentsThe invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof.Compounds of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example as anorectic agents.

Abstract translation: 氮取代六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物，其制备方法及其作为药物的用途本发明涉及取代的六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物 以及其生理上耐受的盐和生理功能衍生物。 描述了其中基团具有所述含义的式I化合物及其生理上耐受的盐及其制备方法。 该化合物适合于例如厌食剂。

公开(公告)号：US20050085483A1

公开(公告)日：2005-04-21

申请号：US10779439

申请日：2004-02-13

Applicant: Stefanie Flohr ,  Siegfried Stengelin ,  Matthias Gossel ,  Thomas Klabunde ,  Petra Stahl ,  Pavel Safar ,  James Spoonamore ,  Martin Smrcina ,  Joseph Klein ,  Gregory Merriman ,  Brian Whiteley ,  Carolina Lanter ,  Kenneth Bordeau ,  Zhaoxia Yang

Inventor： Stefanie Flohr ,  Siegfried Stengelin ,  Matthias Gossel ,  Thomas Klabunde ,  Petra Stahl ,  Pavel Safar ,  James Spoonamore ,  Martin Smrcina ,  Joseph Klein ,  Gregory Merriman ,  Brian Whiteley ,  Carolina Lanter ,  Kenneth Bordeau ,  Zhaoxia Yang

IPC: C07D487/04 ,  A61K31/519

CPC classification number: C07D487/04

Abstract: Nitrogen-substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives, processes for the preparation and their use as medicaments The invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof. in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example as anorectic agents.

Abstract translation: 氮取代六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物，其制备方法及其作为药物的用途本发明涉及取代的六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物 以及其生理上耐受的盐和生理功能衍生物。 其中基团具有所述含义，并且描述了其生理上耐受的盐及其制备方法。 该化合物适合于例如厌食剂。

公开(公告)号：US20080221113A1

公开(公告)日：2008-09-11

申请号：US12124503

申请日：2008-05-21

Applicant: Stefanie Flohr ,  Siegfried Stengelin ,  Matthias Gossel ,  Thomas Klabunde ,  Pavel Safar ,  James Spoonamore ,  Martin Smrcina

Inventor： Stefanie Flohr ,  Siegfried Stengelin ,  Matthias Gossel ,  Thomas Klabunde ,  Pavel Safar ,  James Spoonamore ,  Martin Smrcina

IPC: A61K31/4985 ,  C07D471/04 ,  A61P3/04 ,  A61P3/10 ,  A61P15/00

CPC classification number: C07D487/04

Abstract: Substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives, processes for their preparation and their use as medicamentsThe invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof.Compounds of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example as anorectic agents.

Abstract translation: 取代的六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物，其制备方法及其作为药物的用途本发明涉及取代的六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物， 生理上耐受的盐及其生理功能衍生物。 描述了其中基团具有所述含义的式I化合物及其生理上耐受的盐及其制备方法。 该化合物适合于例如厌食剂。

公开(公告)号：US07390814B2

公开(公告)日：2008-06-24

申请号：US10778554

申请日：2004-02-13

Applicant: Stefanie Flohr ,  Siegfried Stengelin ,  Matthias Gossel ,  Thomas Klabunde ,  Pavel Safar ,  James Spoonamore ,  Martin Smrcina

Inventor： Stefanie Flohr ,  Siegfried Stengelin ,  Matthias Gossel ,  Thomas Klabunde ,  Pavel Safar ,  James Spoonamore ,  Martin Smrcina

IPC: A01N43/90 ,  C07D239/70

CPC classification number: C07D487/04

Abstract: Substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives, processes for their preparation and their use as medicamentsThe invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof.Compounds of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example as anorectic agents.

Abstract translation: 取代的六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物，其制备方法及其作为药物的用途本发明涉及取代的六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物， 生理上耐受的盐及其生理功能衍生物。 描述了其中基团具有所述含义的式I化合物及其生理上耐受的盐及其制备方法。 该化合物适合于例如厌食剂。

公开(公告)号：US20070197539A1

公开(公告)日：2007-08-23

申请号：US11677067

申请日：2007-02-21

Applicant: Petra Lennig ,  Siegfried Stengelin ,  Thomas Klabunde ,  Matthias Gossel ,  Pavel Safar ,  Martin Smrcina ,  James Spoonamore ,  Gregory Merriman ,  Joseph Klein ,  Brian Whiteley ,  Carolina Lanter ,  Kenneth Bordeau ,  Zhaoxia Yang

Inventor： Petra Lennig ,  Siegfried Stengelin ,  Thomas Klabunde ,  Matthias Gossel ,  Pavel Safar ,  Martin Smrcina ,  James Spoonamore ,  Gregory Merriman ,  Joseph Klein ,  Brian Whiteley ,  Carolina Lanter ,  Kenneth Bordeau ,  Zhaoxia Yang

IPC: A61K31/519 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: The invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives substituted with amino acids, and to the physiologically tolerated salts thereof, processes for their preparation and their use as medicaments

Abstract translation: 本发明涉及被氨基酸取代的取代六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物及其生理学上可耐受的盐，其制备方法及其用作药物