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公开(公告)号:USD680891S1
公开(公告)日:2013-04-30
申请号:US29414463
申请日:2012-02-28
申请人: Jason Dallwig , Kristina Remple , Isarnu Sato , Laurel Stone , Adam Zahner
设计人: Jason Dallwig , Kristina Remple , Isarnu Sato , Laurel Stone , Adam Zahner
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公开(公告)号:US07655409B2
公开(公告)日:2010-02-02
申请号:US12240218
申请日:2008-09-29
申请人: Jason Dallwig , David Hagen , Shih-Jung Huang , Gerald Thomas , Stephen Yue
发明人: Jason Dallwig , David Hagen , Shih-Jung Huang , Gerald Thomas , Stephen Yue
CPC分类号: C09B23/02 , C12Q1/6827 , G01N33/582 , Y10T436/143333 , C12Q2527/125 , C12Q2563/107
摘要: Cyanine dye compounds having a negatively charged substituent that are nucleic acid stains, particularly for fluorescent staining of DNA, including compounds having the formula wherein W forms one or two fused 5- or 6-membered aromatic rings, α has a value of 0 or 1, n has a value of 0, or 1, X is O, S, or Se, and D is a pyridinium, or quinolinium moiety, provided that the compound has at least one negatively charged substituent.
摘要翻译: 具有带负电荷的取代基的花青染料化合物,特别是用于DNA的荧光染色的带负电荷的取代基,包括具有下式的化合物,其中W形成一个或两个稠合的5-或6-元芳环,α具有0或1的值 ,n为0或1,X为O,S或Se,D为吡啶鎓或喹啉鎓部分,条件是该化合物具有至少一个带负电荷的取代基。
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公开(公告)号:US08470529B2
公开(公告)日:2013-06-25
申请号:US12851030
申请日:2010-08-05
申请人: Jason Dallwig , David Hagen , Ching-Ying Cheung , Gerald Thomas , Stephen Yue
发明人: Jason Dallwig , David Hagen , Ching-Ying Cheung , Gerald Thomas , Stephen Yue
IPC分类号: A61K31/4709 , C07D215/12 , C12Q1/68
CPC分类号: C09B23/164 , C07D277/64 , C07D417/06 , C09B23/0008 , C09B23/04 , C09B23/06 , C09B23/107 , C12Q1/6806 , C12Q1/6876 , C12Q2600/16 , G01N33/5308 , Y10T436/143333
摘要: Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6 alkyl, sulfoalkyl, carboxyalkyl or C1-C6 alkoxy; each R2 is independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R3, R4, and R5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R3, R4 or R5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.
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公开(公告)号:US20050214810A1
公开(公告)日:2005-09-29
申请号:US11005860
申请日:2004-12-06
申请人: Jason Dallwig , David Hagen , Shih-Jung Huang , Gerald Thomas , Stephen Yue
发明人: Jason Dallwig , David Hagen , Shih-Jung Huang , Gerald Thomas , Stephen Yue
CPC分类号: C09B23/02 , C12Q1/6827 , G01N33/582 , Y10T436/143333 , C12Q2527/125 , C12Q2563/107
摘要: Cyanine dye compounds having a negatively charged substituent that are nucleic acid stains, particularly for fluorescent staining of DNA, including compounds having the formula wherein W forms one or two fused 5- or 6-membered aromatic rings, a has a value of 0 or 1, n has a value of 0, or 1, X is O, S, or Se, and D is a pyridinium, or quinolinium moiety, provided that the compound has at least one negatively charged substituent.
摘要翻译: 具有带负电荷的取代基的花青染料化合物,其特征在于DNA的荧光染色,包括具有下式的化合物,其中W形成一个或两个稠合的5-或6-元芳环,具有0或1的值 ,n为0或1,X为O,S或Se,D为吡啶鎓或喹啉鎓部分,条件是该化合物具有至少一个带负电荷的取代基。
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公开(公告)号:US20050208534A1
公开(公告)日:2005-09-22
申请号:US11005861
申请日:2004-12-06
申请人: Jason Dallwig , David Hagen , Ching-Ying Cheung , Gerald Thomas , Stephen Yue
发明人: Jason Dallwig , David Hagen , Ching-Ying Cheung , Gerald Thomas , Stephen Yue
IPC分类号: C07D413/02 , C07D417/02 , C07H21/04 , C12Q1/68
CPC分类号: C09B23/164 , C07D277/64 , C07D417/06 , C09B23/0008 , C09B23/04 , C09B23/06 , C09B23/107 , C12Q1/6806 , C12Q1/6876 , C12Q2600/16 , G01N33/5308 , Y10T436/143333
摘要: Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6 alkyl, sulfoalkyl, carboxyalkyl or C1-C6 alkoxy; each R2 is independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R3, R4, and R5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R3, R4 or R5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.
摘要翻译: 具有作为核酸污渍的取代的次甲基部分的花青染料化合物,特别是用于RNA的荧光染色,包括具有下式的化合物:其中R 1是C 1 -C 3烷基, 烷基,磺基烷基,羧基烷基或C 1 -C 6烷氧基; 每个R 2独立地选自H,C 1 -C 6烷基,C 1至C 6烷基, -C 6烷氧基,稠合的苯并,三氟甲基,氨基,磺基,羧基和卤素,其任选进一步被取代; R 3,R 4和R 5中的至少一个是任选地是烷基,芳基,杂芳基,环状或杂环部分 被烷基,氨基,氨基烷基,羧基,硝基或卤素取代; 而其余的R 3,R 4或R 5是氢; X是S,O或Se; 并且D是取代或未取代的吡啶鎓,喹啉鎓或苯并咪唑鎓部分。
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公开(公告)号:US07842811B2
公开(公告)日:2010-11-30
申请号:US12686149
申请日:2010-01-12
申请人: Jason Dallwig , David Hagen , Shih-Jung Huang , Gerald Thomas , Stephen Yue
发明人: Jason Dallwig , David Hagen , Shih-Jung Huang , Gerald Thomas , Stephen Yue
IPC分类号: C07D215/38 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号: C09B23/02 , C12Q1/6827 , G01N33/582 , Y10T436/143333 , C12Q2527/125 , C12Q2563/107
摘要: Cyanine dye compounds having a negatively charged substituent that are nucleic acid stains, particularly for fluorescent staining of DNA, including compounds having the formula wherein W forms one or two fused 5- or 6-membered aromatic rings, α has a value of 0 or 1, n has a value of 0, or 1, X is O, S, or Se, and D is a pyridinium, or quinolinium moiety, provided that the compound has at least one negatively charged substituent.
摘要翻译: 具有带负电荷的取代基的花青染料化合物,其特征在于DNA的荧光染色,包括具有下式的化合物,其中W形成一个或两个稠合的5-或6-元芳环,α为0或1 ,n为0或1,X为O,S或Se,D为吡啶鎓或喹啉鎓部分,条件是该化合物具有至少一个带负电荷的取代基。
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