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公开(公告)号：US20140212434A1
公开(公告)日：2014-07-31
申请号：US13983545
申请日：2012-02-02
IPC分类号： C12N15/86 , A61K39/12 , A61K45/06 , A61K39/205
CPC分类号： A61K45/06 , A61K39/08 , A61K39/12 , A61K39/205 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , A61K2039/70 , C12N7/00 , C12N15/86 , C12N2760/14134 , C12N2760/14234 , C12N2760/20043 , C12N2760/20134 , C12N2760/20143
摘要： The present invention provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a filovirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a filovirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present invention provides a recombinant rabies virus vector omprising a nucleotide sequence encoding at least one filovirus glycoprotein or an immunogenic fragment thereof, as well as pharmaceutical compostions comprising the vaccine vectors.
摘要翻译： 本发明提供用于诱导免疫应答的方法和组合物，所述免疫应答赋予双重保护以抵抗狂犬病病毒和弗洛伊病毒中的任一种或两者的感染，和/或可用于治疗性地用于狂犬病病毒和/或病毒性病毒的现有感染 以治疗其至少一种症状和/或中和或清除感染剂。 特别地，本发明提供重组狂犬病病毒载体，其包含编码至少一种病毒糖蛋白或其免疫原性片段的核苷酸序列，以及包含疫苗载体的药物组合物。
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公开(公告)号：US10849975B2
公开(公告)日：2020-12-01
申请号：US13983545
申请日：2012-02-02
摘要： The present invention provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a filovirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a filovirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present invention provides a recombinant rabies virus vector comprising a nucleotide sequence encoding at least one filovirus glycoprotein or an immunogenic fragment thereof, as well as pharmaceutical compositions comprising the vaccine vectors.
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