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公开(公告)号：US20140212434A1
公开(公告)日：2014-07-31
申请号：US13983545
申请日：2012-02-02
IPC分类号： C12N15/86 , A61K39/12 , A61K45/06 , A61K39/205
CPC分类号： A61K45/06 , A61K39/08 , A61K39/12 , A61K39/205 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , A61K2039/70 , C12N7/00 , C12N15/86 , C12N2760/14134 , C12N2760/14234 , C12N2760/20043 , C12N2760/20134 , C12N2760/20143
摘要： The present invention provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a filovirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a filovirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present invention provides a recombinant rabies virus vector omprising a nucleotide sequence encoding at least one filovirus glycoprotein or an immunogenic fragment thereof, as well as pharmaceutical compostions comprising the vaccine vectors.
摘要翻译： 本发明提供用于诱导免疫应答的方法和组合物，所述免疫应答赋予双重保护以抵抗狂犬病病毒和弗洛伊病毒中的任一种或两者的感染，和/或可用于治疗性地用于狂犬病病毒和/或病毒性病毒的现有感染 以治疗其至少一种症状和/或中和或清除感染剂。 特别地，本发明提供重组狂犬病病毒载体，其包含编码至少一种病毒糖蛋白或其免疫原性片段的核苷酸序列，以及包含疫苗载体的药物组合物。
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公开(公告)号：US10849975B2
公开(公告)日：2020-12-01
申请号：US13983545
申请日：2012-02-02
摘要： The present invention provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a filovirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a filovirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present invention provides a recombinant rabies virus vector comprising a nucleotide sequence encoding at least one filovirus glycoprotein or an immunogenic fragment thereof, as well as pharmaceutical compositions comprising the vaccine vectors.
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公开(公告)号：US07081243B1
公开(公告)日：2006-07-25
申请号：US09462543
申请日：1998-07-10
申请人： John K. Rose , Matthias Schnell , E. Erik Johnson
发明人： John K. Rose , Matthias Schnell , E. Erik Johnson
IPC分类号： A61K39/21
CPC分类号： C12N15/86 , C12N2760/20145 , C12N2760/20243 , C12N2810/6054 , C12N2810/855
摘要： Replication-competent recombinant rhabdoviruses that lack a functional glycoprotein gene and express at least one foreign polypeptide such as a celluar receptor for another virus in their viral envelopes are useful in the treatment of pathogenic viruses. In one embodiment, a recombinant vesicular stomatitis virus (VSV) lacking its glycoprotein (G) gene and expressing instead the HIV receptor and a coreceptor is employed in a method for treating persons infected with HIV. The recombinant virus is defective for entry into normal cells but is able to control HIV infection in a T cell line by replicating in, and killing, HIV-infected cells.
摘要翻译： 缺乏功能性糖蛋白基因并在其病毒包膜中表达至少一种外来多肽（例如另一种病毒的纤维素受体）的复制有关的重组弹状病毒可用于治疗病原性病毒。 在一个实施方案中，在用于治疗感染艾滋病毒的人的方法中使用缺乏其糖蛋白（G）基因并且代表性地表达HIV受体和共受体的重组水泡性口炎病毒（VSV）。 重组病毒进入正常细胞是有缺陷的，但能够通过复制和杀死HIV感染细胞来控制T细胞系中的HIV感染。
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4.发明授权公开(公告)号：US07074413B2
公开(公告)日：2006-07-11
申请号：US09816531
申请日：2001-03-23
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K39/205 , A61K2039/5254 , A61K2039/5256 , A61K2039/542 , A61K2039/552 , A61K2039/55516 , C07K2319/00 , C12N7/00 , C12N15/86 , C12N2760/20122 , C12N2760/20134 , C12N2760/20143 , C12N2760/20145 , C12N2760/20161 , C12N2810/6081
摘要： Live, attenuated recombinant rabies virus vaccines are generated using reverse genetics to combine the antigenic determinants that render the rabies virus non-pathogenic with the determinants that are responsible for the elicitation of an effective anti-rabies immune response. These vaccines do not affect the antigenic, and therefore the immunogenic, properties of the virus. The present invention further relates to recombinant rabies virus vaccines that express a pro-apoptotic protein, such as cytochrome c, to increase the capacity to induce apoptosis, thereby enhancing the protective immunity against rabies. This new generation of live rabies virus vaccines represents a safe and effective approach to the eradication of rabies in wildlife, and subsequently humans and livestock.
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公开(公告)号：US07695724B2
公开(公告)日：2010-04-13
申请号：US11571842
申请日：2005-07-12
IPC分类号： A61K39/205 , C12N7/00 , C12N7/01 , C12N15/86
CPC分类号： C12N7/00 , A61K35/13 , C07K14/005 , C12N2760/20121 , C12N2760/20122 , C12N2760/20161
摘要： Recombinant rabies viruses in which the arginine residue of the glycoprotein (G) at amino acid position 333 is exchanged, renders these viruses nonpathogenic for immunocompetent mammals regardless of the route of infection. Some of these recombinant rabies viruses after several serial virus passages in newborn mice can become pathogenic for adult mice. The reversion to the pathogenic phenotype is associated with a thymidine to adenosine mutation (T→A) at position 639 of the G gene, which results in an asparagine to lysine exchange at position 194 of G. The codon at position 637-639 was changed by site directed mutagenesis to replace asparagine at position 194 by an amino acid that minimized the possibility for an Asn→Lys exchange at amino acid position 194 of G and prevents reversion to a pathogenic form of the virus.
摘要翻译： 在氨基酸位置333处交换糖蛋白（G）的精氨酸残基的重组狂犬病毒使得这些病毒对于免疫活性的哺乳动物是非致病性的，而不管感染途径如何。 新生小鼠中几种连续病毒传代后的这些重组狂犬病病毒中的一些可能成为成年小鼠致病的。 对病原性表型的逆转与G基因位置639处的胸苷与腺苷突变（T→A）相关，导致在G位置194处天冬酰胺至赖氨酸交换。位置637-639的密码子被改变 通过位点定向诱变来替代位置194处的天门冬酰胺，其最小化在G的氨基酸位置194处的Asn→Lys交换的可能性，并防止逆转到病毒形式的病原体。
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6.发明授权公开(公告)号：US06239372B1
公开(公告)日：2001-05-29
申请号：US09085231
申请日：1998-05-27
申请人： Bernhard Gartner , Matthias Schnell , Joerg Wolke , Peter Schaefer , Hans-Erich Steinmann , Guenter Trogisch
发明人： Bernhard Gartner , Matthias Schnell , Joerg Wolke , Peter Schaefer , Hans-Erich Steinmann , Guenter Trogisch
IPC分类号： H02G1502
CPC分类号： B81B7/007 , B81B7/0006 , H05K1/0281 , H05K1/189 , H05K3/28 , H05K3/281 , H05K2201/0195 , H05K2201/057 , H05K2201/2009 , H05K2203/1327
摘要： An electrical connection in which a flexible, elastic conductor track carrier is affixed by a connecting end to an electrical component and embedded in potting compound. To prevent breakage at the fastening point at the transition from the potting compound to the outside, the conductor track carrier is reinforced with additional layers of insulating material.
摘要翻译： 一种电连接，其中柔性弹性导体轨道载体通过连接端固定到电气部件并嵌入灌封混合物中。 为了防止在从灌封化合物到外部的过渡处的紧固点处的断裂，导体轨道载体被附加的绝缘材料层增强。
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公开(公告)号：US20100313852A1
公开(公告)日：2010-12-16
申请号：US12744819
申请日：2008-10-31
申请人： Matthias Schnell
发明人： Matthias Schnell
IPC分类号： F02M51/00
CPC分类号： F02M47/027 , F02M63/0015 , F02M63/0043
摘要： The invention relates to a fuel injector comprising a nozzle retainer or an injector body, a valve body and a nozzle body, in which a preferably needle-shaped injection valve member is arranged to be vertically movable, said member releasing or closing at least one injection port leading to a combustion chamber of an internal combustion engine depending on the pressure relief of or the pressure load on a control chamber. The invention is characterized in that a valve comprising a preferably ball-shaped valve element is arranged in the nozzle retainer or in the injector body for the pressure relief of the control chamber.
摘要翻译： 本发明涉及一种燃料喷射器，其包括喷嘴保持器或喷射器主体，阀体和喷嘴体，其中优选地，针状喷射阀构件布置成可垂直移动，所述构件释放或闭合至少一个喷射 根据控制室的压力释放或压力负载而导致内燃机的燃烧室的端口。 本发明的特征在于，包括优选球形阀元件的阀被布置在喷嘴保持器或喷射器主体中用于控制室的压力释放。
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公开(公告)号：US09273780B2
公开(公告)日：2016-03-01
申请号：US13559316
申请日：2012-07-26
摘要： A sliding block for a piston of a hydraulic piston machine, includes a concave recess to receive a piston head and a sliding surface to support the piston. A lubricant channel passes through the sliding block from the concave recess to the sliding surface, and the concave recess transforms with a constant tangent i.e. without kinking into a transition segment of a constantly narrowing taper segment of the lubricant channel. The transition segment is convex.
摘要翻译： 一种用于液压活塞机活塞的滑动块，包括用于容纳活塞头的凹形凹槽和用于支撑活塞的滑动表面。 润滑剂通道通过滑动块从凹形凹部到滑动表面，并且凹形凹槽以恒定的切线变换，即不会扭转到润滑剂通道的不断变窄的锥形段的过渡段中。 过渡段是凸的。
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公开(公告)号：US20130186267A1
公开(公告)日：2013-07-25
申请号：US13559316
申请日：2012-07-26
IPC分类号： F16J1/09
摘要： A sliding block for a piston of a hydraulic piston machine, includes a concave recess to receive a piston head and a sliding surface to support the piston. A lubricant channel passes through the sliding block from the concave recess to the sliding surface, and the concave recess transforms with a constant tangent i.e. without kinking into a transition segment of a constantly narrowing taper segment of the lubricant channel. The transition segment is convex.
摘要翻译： 一种用于液压活塞机活塞的滑动块，包括用于容纳活塞头的凹形凹槽和用于支撑活塞的滑动表面。 润滑剂通道通过滑动块从凹形凹部到滑动表面，并且凹形凹槽以恒定的切线变换，即不会扭转到润滑剂通道的不断变窄的锥形段的过渡段中。 过渡段是凸的。
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公开(公告)号：US08413637B2
公开(公告)日：2013-04-09
申请号：US12744819
申请日：2008-10-31
申请人： Matthias Schnell
发明人： Matthias Schnell
CPC分类号： F02M47/027 , F02M63/0015 , F02M63/0043
摘要： The invention relates to a fuel injector comprising a nozzle retainer or an injector body, a valve body and a nozzle body, in which a preferably needle-shaped injection valve member is arranged to be vertically movable, said member releasing or closing at least one injection port leading to a combustion chamber of an internal combustion engine depending on the pressure relief of or the pressure load on a control chamber. The invention is characterized in that a valve comprising a preferably ball-shaped valve element is arranged in the nozzle retainer or in the injector body for the pressure relief of the control chamber.
摘要翻译： 本发明涉及一种燃料喷射器，其包括喷嘴保持器或喷射器主体，阀体和喷嘴体，其中优选地，针状喷射阀构件布置成可垂直移动，所述构件释放或闭合至少一个喷射 根据控制室的压力释放或压力负载而导致内燃机的燃烧室的端口。 本发明的特征在于，包括优选球形阀元件的阀被布置在喷嘴保持器或喷射器主体中用于控制室的压力释放。
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