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    4-pyrimidinone derivatives their preparation and their application in therapy
    1.
    发明授权
    4-pyrimidinone derivatives their preparation and their application in therapy 失效
    4-嘧啶酮衍生物的制备及其在治疗中的应用

    公开(公告)号：US5472967A

    公开(公告)日：1995-12-05

    申请号：US294023

    申请日：1994-08-24

    申请人： Christian Hoornaert ,  Marc Daumas ,  Michel Aletru ,  Jean-Claude Muller

    发明人： Christian Hoornaert ,  Marc Daumas ,  Michel Aletru ,  Jean-Claude Muller

    IPC分类号： C07D239/36 ,  C07D239/52 ,  C07D403/10 ,  A61K31/505

    CPC分类号： C07D239/36 ,  C07D239/52 ,  C07D403/10

    摘要： Compounds which can be expressed as tautomeric forms and having the formulas (I), (I') and (I") ##STR1## wherein R.sub.1 =a straight or branched (C.sub.1-7) alkyl group or a straight or branched (C.sub.3-9) alkenyl group or a cyclo(C.sub.3-7)alkyl(C.sub.1-6) alkyl group, R.sub.2 =an atom of hydrogen, or a straight or branched (C.sub.1-7)alkyl group, or a cyclo(C.sub.3-7)alkyl(C.sub.1-3)alkyl group, or an aryl(C.sub.1-3)alkyl group optionally substituted on the ring, or an aryloxy(C.sub.1-3)alkyl group optionally substituted on the ring, or an arylthio(C.sub.1-3)alkyl group optionally substituted on the ring, or an arylsulfonyl(C.sub.1-3)alkyl group optionally substituted on the ring, or a heteroaryl(C.sub.1-3)alkyl group optionally substituted on the ring, R.sub.3 =CO.sub.2 H, 1H-tetrazol-5-yl, NHCOR.sub.11, NHSO.sub.2 R.sub.11, CONHSO.sub.2 R.sub.11 or CONHOR.sub.12 group where R.sub.11 =a methyl, trifluoromethyl, or phenyl group optionally substituted, R.sub.12 =a hydrogen atom, or a methyl or a phenyl group optionally substituted. The compounds are useful for antagonizing angiotensin II.

    摘要翻译： 可以表示为互变异构形式并具有式（I），（I'）和（I“）的化合物其中R 1 =直链或支链（C 1-7）烷基 基团或直链或支链（C3-9）烯基或环（C3-7）烷基（C1-6）烷基，R2 =氢原子或直链或支链（C1-7）烷基， 或环（C 3-7）烷基（C 1-3）烷基或任选在环上取代的芳基（C 1-3）烷基或任意在环上取代的芳氧基（C 1-3）烷基，或 或环上任选取代的芳基磺酰基（C 1-3）烷基或环上任选取代的杂芳基（C 1-3）烷基，R 3 = CO 2 H ，1H-四唑-5-基，NHCOR 11，NHSO 2 R 11，CONHSO 2 R 11或CONHOR 12基团，其中R 11 =任选取代的甲基，三氟甲基或苯基，R 12 =氢原子或任选取代的甲基或苯基。 该化合物可用于拮抗血管紧张素II。

    Quinoline derivatives
    3.
    发明授权
    Quinoline derivatives 失效
    喹啉衍生物

    公开(公告)号：US5432283A

    公开(公告)日：1995-07-11

    申请号：US295469

    申请日：1994-08-25

    申请人： Gerard Cremer ,  Pascale Goberville ,  Jean-Claude Muller

    发明人： Gerard Cremer ,  Pascale Goberville ,  Jean-Claude Muller

    IPC分类号： C07D215/12 ,  C07D401/14 ,  C07D403/10 ,  C07D215/16

    CPC分类号： C07D401/14 ,  C07D215/12

    摘要： The present invention provides a compound which is a quinoline derivative of the formula (I) ##STR1## in which R.sub.1 represents either 1H-tetrazol-5-yl, or CO.sub.2 H,R.sub.2 represents either (C.sub.1-7)alkyl or (C.sub.2-6)alkenyl,R.sub.3 and R.sub.4 represent, independently of each other, hydrogen, halogen, cyano group, (C.sub.1-7)alkyl, (C.sub.3-7)cycloalkyl(C.sub.1-4)alkyl, aryl, aryl(C.sub.1-4)alkyl, aryl(C.sub.2-6)alkenyl, --(CH.sub.2).sub.m --COR.sub.5 in which m=0 to 4 and R.sub.5 represents hydrogen, --OH, --(C.sub.1-6)alkoxy, or --NR.sub.7 R.sub.8, R.sub.7 and R.sub.8 representing, independently of each other, hydrogen or --(C.sub.1-4)alkyl group, or a --(CH.sub.2).sub.n --R.sub.6 group in which n=1 to 4 and R.sub.6 represents --OH, --(C.sub.1-6)alkoxy, --(C.sub.1-4)alkoxy(C.sub.1-4)alkoxy, or (C.sub.3-7)cycloalkyl(C.sub.1-4)alkoxy group, or a pharmaceutically acceptable salt thereof and their therapeutic applications.

    摘要翻译： 本发明提供一种化合物，其为式（I）的喹啉衍生物，其中R 1表示1H-四唑-5-基或CO 2 H，R 2表示（C 1-7）烷基或（ C2-6）烯基，R3和R4彼此独立地表示氢，卤素，氰基，（C1-7）烷基，（C3-7）环烷基（C1-4）烷基，芳基，芳基（C1-4 ）烷基，芳基（C2-6）烯基， - （CH2）m-COR5，其中m = 0至4，R5表示氢，-OH， - （C1-6）烷氧基或-NR7R8，R7和R8表示， 氢或 - （C1-4）烷基或其中n = 1-4的R6为R6，R6为-OH的 - （CH2）n-R6基， - （C1-6）烷氧基， - （C1 -4）烷氧基（C 1-4）烷氧基或（C 3-7）环烷基（C 1-4）烷氧基或其药学上可接受的盐及其治疗应用。

    Substituted oxadiazolopyrimidines
    7.
    发明授权
    Substituted oxadiazolopyrimidines 失效
    取代的恶二唑并嘧啶

    公开(公告)号：US4150131A

    公开(公告)日：1979-04-17

    申请号：US873183

    申请日：1978-01-27

    申请人： Jean-Claude Muller ,  Henri Ramuz

    发明人： Jean-Claude Muller ,  Henri Ramuz

    IPC分类号： A61K31/505 ,  A61P9/08 ,  A61P9/12 ,  C07D498/04 ,  C07D498/22

    CPC分类号： C07D498/04

    摘要： Oxadiazolopyrimidine derivatives of the formula ##STR1## wherein R and R.sub.1 are as hereinafter described, prepared, inter alia, by cyclizing a compound of the formula ##STR2## wherein R and R.sub.1 are as hereinafter described. The end products are useful in the treatment of vascular-conditioned hypertension or as vasodilators in the case of peripheral blood supply disorders.

    摘要翻译： 其中R和R 1如下文所述，其中R 1和R 2如下文所述，其中R 1和R 1如下文所述，其中R 1和R 2如下文所述，通过使下式化合物环化来制备。

    Counter-current automatic cleaning filter
    8.
    发明授权
    Counter-current automatic cleaning filter 失效
    逆流自动清洗过滤器

    公开(公告)号：US4119540A

    公开(公告)日：1978-10-10

    申请号：US859182

    申请日：1977-12-09

    申请人： Jean-Claude Muller

    发明人： Jean-Claude Muller

    IPC分类号： B01D46/24 ,  B01D29/11 ,  B01D29/46 ,  B01D29/62 ,  B01D29/66 ,  B01D29/38

    CPC分类号： B01D29/117 ,  B01D2201/0438 ,  B01D2201/287

    摘要： The filter has a filtering chamber in which a number of hollow filtering elements are arranged on a circle about the axis of the filter. The chamber has a liquid inlet and a liquid outlet and the hollow filtering elements communicate in parallel with the inlet and outlet. A hollow arm defining a passageway is rotatable about the axis of the filter and the passageway is capable of putting all the inlets of the filtering elements successively in communication with an impurities discharging chamber in which prevails a pressure lower than the pressure of the filtered liquid. The arm is connected to rotate with the driven member of a unidirectional step-by-step drive mechanism. The arm is also connected to rotate with the driven member of a second unidirectional step-by-step drive mechanism in the same direction as with the first drive mechanism.

    摘要翻译： 过滤器具有过滤室，其中多个中空过滤元件围绕过滤器的轴线布置在圆周上。 腔室具有液体入口和液体出口，并且中空过滤元件与入口和出口平行地连通。 限定通道的空心臂可围绕过滤器的轴线旋转，并且通道能够将过滤元件的所有入口连续地与杂质排出室连通，其中压力低于过滤液体的压力。 臂与单向逐步驱动机构的从动构件连接以旋转。 臂也被连接成与第二单向逐步驱动机构的从动构件沿与第一驱动机构相同的方向旋转。

    Method of injecting a powder containing carbon into a metal bath
    9.
    发明授权
    Method of injecting a powder containing carbon into a metal bath 失效
    将含有碳的粉末注入金属浴中的方法

    公开(公告)号：US4045213A

    公开(公告)日：1977-08-30

    申请号：US762944

    申请日：1977-01-27

    申请人： Pierre Leroy ,  Jean Bastien ,  Jean-Claude Muller ,  Roger Kieger

    发明人： Pierre Leroy ,  Jean Bastien ,  Jean-Claude Muller ,  Roger Kieger

    IPC分类号： C21C5/34 ,  C21C7/00 ,  C21C7/06

    CPC分类号： C21C7/06 ,  C21C5/34 ,  C21C7/0025

    摘要： In a method of deoxidizing and/or carburizing a metal, particularly steel, bath using an immersed nozzle consisting of two concentric tubes, the central tube of the nozzle is fed with an oxidizing gas during the or each oxidation phase, then with a scavenging gas, then with a neutral gas carrying carbon powder or powder containing carbon during the or each deoxidation or carburization phase and finally with a scavenging gas, the outer tube of the nozzle being fed with a protective fluid or different protective fluids during both the oxidation and deoxidation or carburization phases.

    摘要翻译： 在使用由两个同心管组成的浸渍喷嘴的金属，特别是钢，浴的脱氧和/或渗碳的方法中，在该氧化阶段或每个氧化阶段期间，喷嘴的中心管被供给氧化气体，然后用清除气体 然后在该脱氧或渗碳阶段期间用中性气体携带碳粉或含有碳的粉末，最后用清除气体，在氧化和脱氧过程中，喷嘴的外管被供给保护流体或不同的保护流体 或渗碳阶段。

    3-(6-quinolylmethyl)-4H-imidazol-4-one derivatives, their preparation and their application in therapy
    10.
    发明授权
    3-(6-quinolylmethyl)-4H-imidazol-4-one derivatives, their preparation and their application in therapy 失效
    3-（6-喹啉基甲基）-4H-咪唑-4-酮衍生物，其制备及其在治疗中的应用

    公开(公告)号：US5457112A

    公开(公告)日：1995-10-10

    申请号：US165648

    申请日：1993-12-13

    申请人： Gerard Cremer ,  Jean Claude Muller

    发明人： Gerard Cremer ,  Jean Claude Muller

    IPC分类号： C07D401/14 ,  C07D215/04 ,  A61K31/47

    CPC分类号： C07D401/14

    摘要： 3-(6-Quinolylmethyl)-4H-imidazol-4-one derivatives corresponding to the formula (I): ##STR1## in which R.sub.1 represents an unbranched or branched (C.sub.2 -C.sub.5) alkyl group,R.sub.2 and R.sub.3 represent, each independently of one another, either a hydrogen atom, or an unbranched or branched (C.sub.1 -C.sub.5)alkyl group, or a (CH.sub.2).sub.n -aryl group where n=0 to 3, or R.sub.2 and R.sub.3 with the imidazole ring can form a spirocyclo(C.sub.3 -C.sub.8)alkyl group,as well as their addition salts with pharmaceutically acceptable acids and bases.

    摘要翻译： 对应于式（I）的3-（6-喹啉基甲基）-4H-咪唑-4-酮衍生物：其中R 1表示无支链或支链（C2-C5）烷基，R2和R3表示 （C 1 -C 5）烷基或其中n = 0至3的（CH 2）n - 芳基或具有咪唑环的R 2和R 3可彼此独立地为氢原子， 形成螺环（C 3 -C 8）烷基，以及它们与药学上可接受的酸和碱的加成盐。