公开(公告)号：US5484726A

公开(公告)日：1996-01-16

申请号：US1711

申请日：1993-01-07

申请人： Paul Basset ,  Jean-Pierre Bellocq ,  Pierre Chambon

发明人： Paul Basset ,  Jean-Pierre Bellocq ,  Pierre Chambon

IPC分类号： A61K38/00 ,  C12N9/64 ,  C12Q1/25 ,  C07K16/30 ,  C07K16/40

CPC分类号： C12N9/6491 ,  A61K38/00

摘要： The present invention relates to a gene encoding stromylsin-3, which is a new member of the metalloproteinase family. Expression of the stromelysin-3 gene has been found to be specifically associated with invasive breast, head, neck and skin cancer. The invention also relates to antibodies which specifically bind to human stromylsin-3 and the use of these stromelysin-3 antibodies for detection of the stromylsin-3 protein in a sample.

摘要翻译： 本发明涉及编码基质蛋白酶-3的基因，其是金属蛋白酶家族的新成员。 已经发现基质溶素-3基因的表达与浸润性乳腺癌，头部，颈部和皮肤癌特异性相关。 本发明还涉及特异性结合人类基质蛋白-3的抗体以及这些基质溶素-3抗体用于检测样品中的基质蛋白-3蛋白的用途。

公开(公告)号：US5635596A

公开(公告)日：1997-06-03

申请号：US989886

申请日：1992-12-10

申请人： Pierre Chambon ,  Marie-Christine nee Martinet Rio ,  Jean-Pierre Bellocq

发明人： Pierre Chambon ,  Marie-Christine nee Martinet Rio ,  Jean-Pierre Bellocq

IPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/00 ,  C07K16/00 ,  C07K16/30

CPC分类号： C07K14/47

摘要： Peptides derived from the pS2 protein and polyclonal and monoclonal antibodies directed against pS2 and against pS2 fragments. Method of obtaining the secreted from of the pS2 protein and fragments thereof. Method of detecting and diagnosing different pathological conditions and especially hormone-dependent breast cancers and pathological conditions of the stomach.

摘要翻译： 衍生自pS2蛋白的肽和针对pS2和针对pS2片段的多克隆和单克隆抗体。 获得从pS2蛋白及其片段分泌的方法。 检测和诊断不同病理状况，特别是激素依赖性乳腺癌和胃病理状态的方法。

公开(公告)号：US5236844A

公开(公告)日：1993-08-17

申请号：US794393

申请日：1991-11-21

申请人： Paul Basset ,  Jean-Pierre Bellocq ,  Pierre Chambon

发明人： Paul Basset ,  Jean-Pierre Bellocq ,  Pierre Chambon

IPC分类号： A61K51/00 ,  A61K38/00 ,  C12N9/64 ,  C12N15/09 ,  C12N15/57 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/37 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/50 ,  G01N33/53 ,  G01N33/574

CPC分类号： C12N9/6491 ,  A61K38/00

摘要： The present invention relates to a gene encoding a new member of the metalloproteinase family which has been found to be specifically associated with invasive breast cancer, and to methods of diagnosis for such cancer comprising detection of the marker or its nucleotide sequence, and to treatment or prophylaxis by inhibiting, altering the activity of or binding the marker, or by interfering with its synthesis.

摘要翻译： 本发明涉及已经发现与侵袭性乳腺癌特异性相关的编码金属蛋白酶家族的新成员的基因，以及包括检测标记或其核苷酸序列的这种癌症的诊断方法，以及治疗或 通过抑制，改变标记的活性或结合标记，或通过干扰其合成来预防。