公开(公告)号：US10183131B1

公开(公告)日：2019-01-22

申请号：US14807112

申请日：2015-07-23

申请人： Jeffrey M. Skell

发明人： Jeffrey M. Skell

IPC分类号： A61M11/04 ,  A61M16/06

摘要： An extraction system uses a sample of botanical matter which has been rendered into particles of a predetermined range of sizes and compressed into a non-flowable form. The sample is loaded into an extraction chamber which may be sealed. A conductive or convective heat source is used to heat the loaded sample to a temperature which causes at least one substance within the sample to vaporize. A conduit can be used to transfer vapor resulting from vaporization of the substance to a collection chamber and mask. Pressure may be adjusted within the system to facilitate vaporization and vapor transport.

公开(公告)号：US20190270032A1

公开(公告)日：2019-09-05

申请号：US16412467

申请日：2019-05-15

申请人： Jeffrey M. Skell

发明人： Jeffrey M. Skell

IPC分类号： B01D11/02 ,  A61K36/00

摘要： A useful substance is extracted from botanical feedstock by mechanically compressing the feedstock and pumping a solvent through the compressed feedstock at high pressure while applying compressive mechanical force against the feedstock. Movement of pressurized solvent through the compressed feedstock may increase the volume of solvent in contact with the feedstock. Flow of solvent under pressure may also present a shearing force that facilitates dissociation of the useful substance from the feedstock.

公开(公告)号：US07192962B2

公开(公告)日：2007-03-20

申请号：US10449650

申请日：2003-05-30

申请人： Vilas H. Dahanukar ,  Hoa N. Nguyen ,  Cecilia A. Orr ,  Funcheng Zhang ,  Ilia A. Zavialov ,  Kevin Klopfer ,  Jeffrey M. Skell ,  Albert W. Buchholz, Jr. ,  Craig D. Boyle

发明人： Vilas H. Dahanukar ,  Hoa N. Nguyen ,  Cecilia A. Orr ,  Funcheng Zhang ,  Ilia A. Zavialov ,  Kevin Klopfer ,  Jeffrey M. Skell ,  Albert W. Buchholz, Jr. ,  Craig D. Boyle

IPC分类号： A07D473/04 ,  A61K31/522 ,  A61P9/12 ,  A61P15/10

CPC分类号： C07D473/04

摘要： Crystalline polymorphs of 1-ethyl-3,7-dihydro-8-[(1R,2R) -(hydroxycyclopentyl)amino]-3-(2-hydroxyethyl)-7-[(3-bromo-4-methoxyphenyl)methyl]-1H-Purine-2,6-dione in Form 1 and Form 2, which exhibit x-ray powder diffraction profiles substantially the same as those shown in FIGS. 5 and 6, respectively, and which exhibit differential scanning calorimtery profiles substantially the same as those shown in FIGS. 2 and 4, respectively, and are represented by the formula: Pharmaceutical compositions comprising the polymorph Form 1 or 2 of Compound 13 and at least one excipient or carrier, and methods of using the polymorph Form 1 or 2 of Compound 13 to treat a variety of physiological disorders, such as erectile dysfunction.

摘要翻译： 1-乙基-3,7-二氢-8 - [（1R，2R） - （羟基环戊基）氨基] -3-（2-羟乙基）-7 - [（3-溴-4-甲氧基苯基）甲基] 形式1和形式2的-1H-嘌呤-2,6-二酮，其显示与图1和2所示的X-射线粉末衍射分布基本相同的X-射线粉末衍射分布。 分别示出了与图1和图2所示的相似的差示扫描量热分析图。 2和4，并且由下式表示：包含化合物13的多晶型物1或2和至少一种赋形剂或载体的药物组合物，以及使用化合物13的多晶型物1或2的方法来处理多种 的生理障碍，如勃起功能障碍。

公开(公告)号：US10328361B2

公开(公告)日：2019-06-25

申请号：US15053687

申请日：2016-02-25

申请人： Jeffrey M. Skell

发明人： Jeffrey M. Skell

IPC分类号： A61K36/00 ,  B01D11/02

摘要： A useful substance is extracted from botanical feedstock by mechanically compressing the feedstock and pumping a solvent through the compressed feedstock at high pressure while applying compressive mechanical force against the feedstock. Movement of pressurized solvent through the compressed feedstock may increase the volume of solvent in contact with the feedstock. Flow of solvent under pressure may also present a shearing force that facilitates dissociation of the useful substance from the feedstock.

公开(公告)号：US20170246557A1

公开(公告)日：2017-08-31

申请号：US15053687

申请日：2016-02-25

申请人： Jeffrey M. Skell

发明人： Jeffrey M. Skell

IPC分类号： B01D11/02 ,  A61K36/00

CPC分类号： B01D11/0219 ,  A61K36/00 ,  A61K2236/00 ,  B01D11/0292

摘要： A useful substance is extracted from botanical feedstock by mechanically compressing the feedstock and pumping a solvent through the compressed feedstock at high pressure while applying compressive mechanical force against the feedstock. Movement of pressurized solvent through the compressed feedstock may increase the volume of solvent in contact with the feedstock. Flow of solvent under pressure may also present a shearing force that facilitates dissociation of the useful substance from the feedstock.