公开(公告)号：US20110154518A1

公开(公告)日：2011-06-23

申请号：US12993890

申请日：2009-05-26

申请人： Jeong Beom Kim ,  Holm Zaehres ,  Hans Robert Scholer

发明人： Jeong Beom Kim ,  Holm Zaehres ,  Hans Robert Scholer

IPC分类号： A01K67/00 ,  C12N15/87 ,  C12N5/10 ,  C12Q1/02 ,  A61D19/04

CPC分类号： C12N5/0696 ,  A61D19/04 ,  C12N15/85 ,  C12N15/8509 ,  C12N15/873 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2502/13 ,  C12N2506/08 ,  C12N2506/13 ,  C12N2510/00 ,  C12N2799/027 ,  G01N33/5073

摘要： The present invention relates to a method of generating an induced pluripotent stem (iPS) cell comprising the step of introducing into a target cell one or two coding sequences each giving rise upon transcription to a factor that contributes to the reprogramming of said target cell into an induced pluripotent stem cell and selected from Oct3/4 or a factor belonging to the Myc, Klf and Sox families of factors, wherein the target cell endogenously expresses at least the factors that are not encoded by the coding sequences to be introduced and selected from Oct3/4 or factors belonging to the Myc, Klf and Sox families of factors, and wherein the cell resulting from the introduction of the one or two coding sequences expresses the combination of factor Oct3/4 and at least one factor of each family of factors selected from the group of Myc, Klf and Sox. Furthermore, the present invention relates to an induced pluripotent stem cell generated by the method of the invention and a method of identifying a compound that contributes to the reprogramming of a target cell into an induced pluripotent stem cell. Also, a method of generating a transgenic non-human animal and a composition comprising an iPS cell generated by the method of the present invention for gene therapy, regenerative medicine, cell therapy or drug screening are envisaged.

摘要翻译： 本发明涉及一种产生诱导多能干细胞（iPS）细胞的方法，该方法包括以下步骤：向靶细胞中引入一个或两个编码序列，每个编码序列在转录时产生有助于将所述靶细胞重新编程成 诱导多能干细胞，选自Oct3 / 4或属于Myc，Klf和Sox家族因子的因子，其中目标细胞至少内源性表达至少不是由Oct3引入和选择的编码序列编码的因子 / 4或属于Myc，Klf和Sox家族因子的因子，并且其中由引入一个或两个编码序列产生的细胞表达因子Oct3 / 4与所选因子的至少一个因子的组合 从Myc，Klf和Sox组。 此外，本发明涉及通过本发明的方法产生的诱导多能干细胞和鉴定有助于靶细胞重编程为诱导多能干细胞的化合物的方法。 此外，设想生成转基因非人动物的方法和包含通过本发明的方法产生的用于基因治疗，再生医学，细胞治疗或药物筛选产生的iPS细胞的组合物。

公开(公告)号：US08894853B2

公开(公告)日：2014-11-25

申请号：US13102260

申请日：2011-05-06

申请人： Jeong Beom Kim

发明人： Jeong Beom Kim

IPC分类号： B01D35/30 ,  C02F9/00 ,  C02F1/44 ,  C02F1/00 ,  C02F1/28

CPC分类号： C02F9/005 ,  B01D35/30 ,  B01D2201/302 ,  B01D2201/4015 ,  C02F1/001 ,  C02F1/283 ,  C02F1/441 ,  C02F1/444 ,  C02F2201/004 ,  C02F2201/006

摘要： A filter device for a water purifier including a filter unit having a flange having an inlet, an outlet, an optional discharge port, opposite engaging protrusions, and opposite engaging recesses; a connecting member fitted into the flange so as to be connected with the inlet, the outlet, and optional discharge port and having inner communicating passages so as to be connected with respective connecting holes, a cap member fitted around the flange to cover the connecting member and having on an outer circumference connecting ports communicating with the respective connecting holes, the cap member having opposite engaging holes corresponding to the engaging protrusions and opposite engaging grooves corresponding to the engaging recesses, and a fixing member engaging on an inner end with the engaging recess through the engaging groove.

摘要翻译： 一种用于净水器的过滤装置，其包括具有凸缘的过滤器单元，所述凸缘具有入口，出口，可选的排出口，相对的接合突起和相对的接合凹槽; 连接构件，其装配到所述凸缘中，以便与所述入口，所述出口和任选的排放口连接，并且具有内连通通道，以便与相应的连接孔连接;盖构件，其围绕所述凸缘装配以覆盖所述连接构件 并且具有连接与各个连接孔连通的端口的外周，所述盖构件具有与所述接合突起相对应的相对的接合孔和对应于所述接合凹部的相对的接合槽，以及固定构件，所述固定构件与所述接合凹部 通过接合槽。

公开(公告)号：US20120228206A1

公开(公告)日：2012-09-13

申请号：US13102260

申请日：2011-05-06

申请人： Jeong Beom KIM

发明人： Jeong Beom KIM

IPC分类号： B01D35/30

CPC分类号： C02F9/005 ,  B01D35/30 ,  B01D2201/302 ,  B01D2201/4015 ,  C02F1/001 ,  C02F1/283 ,  C02F1/441 ,  C02F1/444 ,  C02F2201/004 ,  C02F2201/006

摘要： An easy-fit filter device for a water purifier including a filter unit having a flange having an inlet, an outlet, opposite engaging protrusions, and opposite engaging recesses, a connecting member fitted into the flange so as to be connected with the inlet and the outlet and having inner communicating passages so as to be connected with respective connecting holes, a cap member fitted around the flange to cover the connecting member and having on an outer circumference connecting ports communicating with the respective connecting holes, the cap member having opposite engaging holes corresponding to the engaging protrusions and opposite engaging grooves corresponding to the engaging recesses, and a fixing member engaging on an inner end with the engaging recess through the engaging groove.

摘要翻译： 一种用于净水器的易于安装的过滤装置，其包括具有凸缘的过滤器单元，该凸缘具有入口，出口，相对的接合突起和相对的接合凹部，连接构件装配到凸缘中，以便与入口和 出口，并且具有内连通通道，以便与相应的连接孔连接;帽构件，其围绕所述凸缘安装以覆盖所述连接构件，并且在外周上连接与各连接孔连通的端口，所述盖构件具有相对的接合孔 对应于接合突起和对应于接合凹部的相对的接合槽，以及固定构件，其通过接合槽与接合凹部接合在内端上。

公开(公告)号：US20110138185A1

公开(公告)日：2011-06-09

申请号：US12911064

申请日：2010-10-25

申请人： Hak-soo JU ,  Su-hyun NAM ,  Jeong-beom KIM ,  Eun-hwa HONG

发明人： Hak-soo JU ,  Su-hyun NAM ,  Jeong-beom KIM ,  Eun-hwa HONG

IPC分类号： H04L9/32 ,  G06F9/44 ,  H04L9/08

CPC分类号： G06F21/10 ,  H04L9/0891 ,  H04L9/3213 ,  H04L9/3271 ,  H04L2209/603

摘要： A method and apparatus for updating data, the method including: receiving a forced update command to forcibly update at least one of a first digital rights management (DRM) module and a first device key stored in the device; receiving a DRM package including at least one of a second DRM module and a second device key based on the forced update command; and updating the at least one of the first DRM module and the first device key based on the received DRM package.

摘要翻译： 一种用于更新数据的方法和装置，所述方法包括：接收强制更新命令，以强制更新存储在所述设备中的第一数字版权管理（DRM）模块和第一设备密钥中的至少一个; 基于强制更新命令，接收包含第二DRM模块和第二设备密钥中的至少一个的DRM包; 以及基于所接收的DRM包更新所述第一DRM模块和所述第一设备密钥中的至少一个。

公开(公告)号：US20120266091A1

公开(公告)日：2012-10-18

申请号：US13297961

申请日：2011-11-16

申请人： Jeong-beom KIM ,  Su-hyun NAM ,  Ho-jung LEE

发明人： Jeong-beom KIM ,  Su-hyun NAM ,  Ho-jung LEE

IPC分类号： G06F3/00

CPC分类号： G06Q30/02 ,  G06Q50/01 ,  H04W4/021 ,  H04W4/21

摘要： A method and apparatus for representing a user device and a service as social objects include: registering user information; receiving social Web service account information of the user from a social Web service, and registering the social Web service account information in relation to the user information; and receiving information about the user device and information about services executed in the user device, and registering the received information in relation to the user information.

摘要翻译： 用于将用户设备和服务表示为社交对象的方法和装置包括：注册用户信息; 从社交Web服务接收用户的社交Web服务帐户信息，以及登记与用户信息相关的社交Web服务帐户信息; 并且接收关于用户设备的信息和关于在用户设备中执行的服务的信息，以及关于用户信息登记接收到的信息。