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公开(公告)号:US5955496A
公开(公告)日:1999-09-21
申请号:US909523
申请日:1997-08-12
申请人: Bruce D. Hammock , Mehran F. Moghaddam , Jeffrey M. Cheek , Babak Borhan , James Fergusson , David F. Grant , Jessica F. Greene , Kazuhiko Matoba , Jiang Zheng , Marlene F. Sisemore
发明人: Bruce D. Hammock , Mehran F. Moghaddam , Jeffrey M. Cheek , Babak Borhan , James Fergusson , David F. Grant , Jessica F. Greene , Kazuhiko Matoba , Jiang Zheng , Marlene F. Sisemore
IPC分类号: A61K31/155 , A61K31/20 , A61K31/336 , A61K31/34 , C07D307/12
CPC分类号: A61K31/7088 , A61K31/155 , A61K31/20 , A61K31/336 , G01N2500/10
摘要: The present invention provides novel biologically active tetrahydrofuran diols of arachidonic acid.
摘要翻译: 本发明提供花生四烯酸的新型生物活性四氢呋喃二醇。
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公开(公告)号:US06174695B1
公开(公告)日:2001-01-16
申请号:US09312207
申请日:1999-05-14
申请人: Bruce D. Hammock , Mehran F. Moghaddam , Jeffrey M. Cheek , Babak Borhan , James Fergusson , David F. Grant , Jessica F. Greene , Kazuhiko Matoba , Jiang Zheng , Marlene F. Sisemore
发明人: Bruce D. Hammock , Mehran F. Moghaddam , Jeffrey M. Cheek , Babak Borhan , James Fergusson , David F. Grant , Jessica F. Greene , Kazuhiko Matoba , Jiang Zheng , Marlene F. Sisemore
IPC分类号: C12Q134
CPC分类号: C12Q1/34 , G01N2500/10
摘要: The present invention provides methods of treating inflammatory diseases mediated by poly-unsaturated lipid metabolites by inhibiting epoxide hydrolase, methods for assaying or screening the epoxide hydrolase inhibitors for inhibitory specificity and for toxicity, and novel biologically active tetrahydrofuran diols of arachidonic acid, including antibodies thereto.
摘要翻译: 本发明提供了通过抑制环氧化物水解酶来治疗由多不饱和脂质代谢物介导的炎性疾病的方法,用于测定或筛选环氧化物水解酶抑制剂以抑制特异性和毒性的方法,以及花生四烯酸的新型生物活性四氢呋喃二醇,包括其抗体 。
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