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公开(公告)号：US06174695B1
公开(公告)日：2001-01-16
申请号：US09312207
申请日：1999-05-14
申请人： Bruce D. Hammock , Mehran F. Moghaddam , Jeffrey M. Cheek , Babak Borhan , James Fergusson , David F. Grant , Jessica F. Greene , Kazuhiko Matoba , Jiang Zheng , Marlene F. Sisemore
发明人： Bruce D. Hammock , Mehran F. Moghaddam , Jeffrey M. Cheek , Babak Borhan , James Fergusson , David F. Grant , Jessica F. Greene , Kazuhiko Matoba , Jiang Zheng , Marlene F. Sisemore
IPC分类号： C12Q134
CPC分类号： C12Q1/34 , G01N2500/10
摘要： The present invention provides methods of treating inflammatory diseases mediated by poly-unsaturated lipid metabolites by inhibiting epoxide hydrolase, methods for assaying or screening the epoxide hydrolase inhibitors for inhibitory specificity and for toxicity, and novel biologically active tetrahydrofuran diols of arachidonic acid, including antibodies thereto.
摘要翻译： 本发明提供了通过抑制环氧化物水解酶来治疗由多不饱和脂质代谢物介导的炎性疾病的方法，用于测定或筛选环氧化物水解酶抑制剂以抑制特异性和毒性的方法，以及花生四烯酸的新型生物活性四氢呋喃二醇，包括其抗体 。
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公开(公告)号：US5955496A
公开(公告)日：1999-09-21
申请号：US909523
申请日：1997-08-12
申请人： Bruce D. Hammock , Mehran F. Moghaddam , Jeffrey M. Cheek , Babak Borhan , James Fergusson , David F. Grant , Jessica F. Greene , Kazuhiko Matoba , Jiang Zheng , Marlene F. Sisemore
发明人： Bruce D. Hammock , Mehran F. Moghaddam , Jeffrey M. Cheek , Babak Borhan , James Fergusson , David F. Grant , Jessica F. Greene , Kazuhiko Matoba , Jiang Zheng , Marlene F. Sisemore
IPC分类号： A61K31/155 , A61K31/20 , A61K31/336 , A61K31/34 , C07D307/12
CPC分类号： A61K31/7088 , A61K31/155 , A61K31/20 , A61K31/336 , G01N2500/10
摘要： The present invention provides novel biologically active tetrahydrofuran diols of arachidonic acid.
摘要翻译： 本发明提供花生四烯酸的新型生物活性四氢呋喃二醇。
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公开(公告)号：US08815951B2
公开(公告)日：2014-08-26
申请号：US11566171
申请日：2006-12-01
申请人： Bruce D Hammock , Jiang Zheng , Christophe Morisseau , Kazuhiko Motoba , Mehran F. Moghaddam , Babak Borhan , David F. Grant , Jessica Greene , Marlene F. Sisemore , James Sanborn
发明人： Bruce D Hammock , Jiang Zheng , Christophe Morisseau , Kazuhiko Motoba , Mehran F. Moghaddam , Babak Borhan , David F. Grant , Jessica Greene , Marlene F. Sisemore , James Sanborn
摘要： The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R1-R4 is hydrogen, R2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R1 and R3 is each independently C1-C20 substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.
摘要翻译： 本发明提供在治疗高血压的治疗应用中抑制环氧化物水解酶的化合物。 用于实施本发明的一类优选的化合物具有式1所示的结构，其中Z是氧或硫，W是碳磷或硫，X和Y各自独立地是氮，氧或硫，并且X还可以是碳， 当X为氮时，R 1为R 4为氢，R 2为氢时，当X为硫或氧时不存在，当Y为氮时为R4，当Y为硫或氧时不存在，R 1和R 3为 各自独立地为C1-C20取代或未取代的烷基，环烷基，芳基，酰基或杂环。
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公开(公告)号：US20070117782A1
公开(公告)日：2007-05-24
申请号：US11566171
申请日：2006-12-01
申请人： Bruce Hammock , Jiang Zheng , Christophe Morisseau , Kazuhiko Motoba , Mehran Moghaddam , Babak Borhan , David Grant , Jessica Greene , Marlene Sisemore , James Sanborn
发明人： Bruce Hammock , Jiang Zheng , Christophe Morisseau , Kazuhiko Motoba , Mehran Moghaddam , Babak Borhan , David Grant , Jessica Greene , Marlene Sisemore , James Sanborn
摘要： The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R1-R4 is hydrogen, R2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R1 and R3 is each independently C1-C20 substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.
摘要翻译： 本发明提供在治疗高血压的治疗应用中抑制环氧化物水解酶的化合物。 用于实施本发明的一类优选的化合物具有式1所示的结构，其中Z是氧或硫，W是碳磷或硫，X和Y各自独立地是氮，氧或硫，并且X还可以是碳， R 1至R 4中的至少一个为氢，当X为氮时，R 2为氢，但当X为硫或不存在时不存在 当Y为氮时，氧，R 4为氢，但当Y为硫或氧时不存在，R 1和R 3各自独立地为 C 1 -C 20取代或未取代的烷基，环烷基，芳基，酰基或杂环。
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公开(公告)号：US06495370B1
公开(公告)日：2002-12-17
申请号：US09639392
申请日：2000-08-15
IPC分类号： G01N3300
CPC分类号： C07D405/06 , C07D307/58 , Y10S977/893 , Y10S977/896 , Y10S977/915 , Y10T436/20
摘要： This invention relates to novel haloenol lactone compounds. These compounds have the following general structure: in which Ar is an aryl group and Y is a haloenol lactone moiety. The compounds of the invention are useful for the specific measurement of particular isoenzymes of glutathione S-transferase. Measurement of glutathione S-transferase isoenzymes has importance in diagnostic medicine. The compounds of the invention are also useful for treatment of drug resistance in cancer and for preventing herbicide resistance in plants.
摘要翻译： 本发明涉及新的卤烯醇内酯化合物。 这些化合物具有以下一般结构：其中Ar是芳基，Y是卤代烯内酯部分。本发明的化合物可用于特异性测量谷胱甘肽S-转移酶的特定同工酶。 谷胱甘肽S-转移酶同工酶的测定在诊断医学中具有重要意义。 本发明的化合物还可用于治疗癌症中的耐药性和用于防止植物中的除草剂抗性。
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公开(公告)号：US5767147A
公开(公告)日：1998-06-16
申请号：US426593
申请日：1995-04-21
IPC分类号： C07D307/58 , C07D405/06 , C12Q1/48 , G01N33/00 , A61K31/35
CPC分类号： C07D405/06 , C07D307/58 , Y10S977/893 , Y10S977/896 , Y10S977/915 , Y10T436/20
摘要： This invention relates to novel haloenol lactone compounds. These compounds have the following general structure: ##STR1## in which Ar is an aryl group and Y is a haloenol lactone moiety. The compounds of the invention are useful for the specific measurement of particular isoenzymes of glutathione S-transferase. Measurement of glutathione S-transferase isoenzymes has importance in diagnostic medicine. The compounds of the invention are also useful for treatment of drug resistance in cancer and for preventing herbicide resistance in plants.
摘要翻译： 本发明涉及新的卤烯醇内酯化合物。 这些化合物具有以下一般结构：其中Ar是芳基，Y是卤代烯内酯部分的
。 本发明的化合物可用于特异性测量谷胱甘肽S-转移酶的特定同工酶。 谷胱甘肽S-转移酶同工酶的测定在诊断医学中具有重要意义。 本发明的化合物还可用于治疗癌症中的耐药性和用于防止植物中的除草剂抗性。 -
公开(公告)号：US6150415A
公开(公告)日：2000-11-21
申请号：US252148
申请日：1999-02-18
申请人： Bruce D. Hammock , Christophe H. Morisseau , Jiang Zheng , Marvin H. Goodrow , Tonya Severson , James Sanborn
发明人： Bruce D. Hammock , Christophe H. Morisseau , Jiang Zheng , Marvin H. Goodrow , Tonya Severson , James Sanborn
IPC分类号： C12N9/14 , A01N47/10 , A01N47/28 , A61K31/00 , A61K31/155 , A61K31/17 , A61K31/20 , A61K31/336 , A61K38/46 , A61P11/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07C275/06 , C07C275/26 , C07C333/06 , C12N9/99
CPC分类号： A61K31/155 , A61K31/00 , A61K31/17 , A61K31/20 , A61K31/27 , A61K31/336 , A61K31/7088 , G01N2500/10
摘要： Biologically stable inhibitors of soluble epoxide hydrolases are provided. The inhibitors can be used, for example, to selectively inhibit epoxide hydrolase in therapeutic applications such as treating inflammation, for use in affinity separations of the epoxide hydrolases, and in agricultural applications. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 ##STR1## wherein X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R.sub.1 -R.sub.4 is hydrogen, R.sub.2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R.sub.4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R.sub.1 and R.sub.3 are each independently a substituted or unsubstituted alkyl, haloalkyl, cycloalkyl, aryl, acyl, or heterocyclic, or being a metabolite or degradation product thereof.
摘要翻译： 提供了生物稳定的可溶性环氧化物水解酶抑制剂。 抑制剂可用于例如在治疗应用中选择性抑制环氧化物水解酶，例如治疗炎症，用于环氧化物水解酶的亲和分离，以及在农业应用中。 用于实施本发明的优选类化合物具有式1所示的结构，其中X和Y各自独立地为氮，氧或硫，X可以进一步为碳，R 1 -R 4中的至少一个为氢，R 2为氢 当X是氮而X是硫或氧时不存在，当Y是氮时，R4是氢，当Y是硫或氧时不存在，R 1和R 3各自独立地是取代或未取代的烷基，卤代烷基，环烷基，芳基 ，酰基或杂环，或其代谢产物或降解产物。
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公开(公告)号：US06103665A
公开(公告)日：2000-08-15
申请号：US94926
申请日：1998-06-15
IPC分类号： C07D307/58 , C07D405/06 , C12Q1/48 , G01N33/00 , A01N43/02 , A01N43/08
CPC分类号： C07D405/06 , C07D307/58 , Y10S977/893 , Y10S977/896 , Y10S977/915 , Y10T436/20
摘要： This invention relates to novel haloenol lactone compounds. These compounds have the following general structure: ##STR1## in which Ar is an aryl group and Y is a haloenol lactone moiety. The compounds of the invention are useful for the specific measurement of particular isoenzymes of glutathione S-transferase. Measurement of glutathione S-transferase isoenzymes has importance in diagnostic medicine. The compounds of the invention are also useful for treatment of drug resistance in cancer and for preventing herbicide resistance in plants.
摘要翻译： 本发明涉及新的卤烯醇内酯化合物。 这些化合物具有以下一般结构：其中Ar是芳基，Y是卤代烯内酯部分。 本发明的化合物可用于特异性测量谷胱甘肽S-转移酶的特定同工酶。 谷胱甘肽S-转移酶同工酶的测定在诊断医学中具有重要意义。 本发明的化合物还可用于治疗癌症中的耐药性和用于防止植物中的除草剂抗性。
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公开(公告)号：US20130289112A1
公开(公告)日：2013-10-31
申请号：US13884558
申请日：2011-03-21
申请人： Jiang Zheng , Xinchuan Zheng , Xin Liu , Hong Zhou , Ning Wang , Hongwei Cao , Yan Li , Yongling Lu , Kecen Zhao , Jingcheng Yang , Yang Yang , Yuanfeng Zhu , Guo Wei , Min Huang
发明人： Jiang Zheng , Xinchuan Zheng , Xin Liu , Hong Zhou , Ning Wang , Hongwei Cao , Yan Li , Yongling Lu , Kecen Zhao , Jingcheng Yang , Yang Yang , Yuanfeng Zhu , Guo Wei , Min Huang
IPC分类号： C07C235/34 , C07C55/10 , C07C57/145 , C07C229/24 , C07C59/08 , C07C59/255 , C07C309/04 , C07C309/30 , C07C53/10 , C07C59/245
CPC分类号： C07C309/04 , C07C53/08 , C07C53/10 , C07C53/122 , C07C53/124 , C07C55/06 , C07C55/08 , C07C55/10 , C07C55/14 , C07C57/145 , C07C57/15 , C07C57/44 , C07C59/08 , C07C59/245 , C07C59/255 , C07C59/265 , C07C59/50 , C07C63/06 , C07C229/24 , C07C235/34 , C07C309/25 , C07C309/30
摘要： Salts of kukoamine B, their preparation method and their pharmaceutical use in preparation of drugs for preventing and treating sepsis. Experiments indicate that salts of kukoamine B have a good effect on antagonizing the key factors inducing sepsis, and can be used in the preparation of drugs for preventing and treating sepsis. Under the current circumstances of the lack of effective measures for the treatment of sepsis in clinical practice, the medicinal formulations, which comprise the salts of kukoamine B, pharmaceutically acceptable carrier and/or diluent, provide a new approach for the prevention and treatment of sepsis.
摘要翻译： kukoamine B的盐，它们的制备方法及其制备用于预防和治疗败血症药物的药物用途。 实验表明，kukoamine B的盐对拮抗诱导败血症的关键因素具有很好的疗效，可用于制备预防和治疗败血症的药物。 目前在临床实践中缺乏治疗败血症的有效措施的情况下，包含kukoamine B，药学上可接受的载体和/或稀释剂的盐的药物制剂提供了预防和治疗败血症的新方法 。
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公开(公告)号：US20060035869A1
公开(公告)日：2006-02-16
申请号：US11240444
申请日：2005-09-29
申请人： Bruce Hammock , Christophe Morisseau , Jiang Zheng , Marvin Goodrow , Tonya Severson , James Sanborn
发明人： Bruce Hammock , Christophe Morisseau , Jiang Zheng , Marvin Goodrow , Tonya Severson , James Sanborn
CPC分类号： A61K31/325 , A61K31/00 , A61K31/336
摘要： Biologically stable inhibitors of soluble epoxide hydrolases are provided. The inhibitors can be used, for example, to selectively inhibit epoxide hydrolase in therapeutic applications such as treating inflammation, for use in affinity separations of the epoxide hydrolases, and in agricultural applications. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 wherein X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R1-R4 is hydrogen, R2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R1 and R3 are each independently a substituted or unsubstituted alkyl, haloalkyl, cycloalkyl, aryl, acyl, or heterocyclic, or being a metabolite or degradation product thereof.
摘要翻译： 提供了生物稳定的可溶性环氧化物水解酶抑制剂。 抑制剂可用于例如在治疗应用中选择性抑制环氧化物水解酶，例如治疗炎症，用于环氧化物水解酶的亲和分离，以及在农业应用中。 用于实施本发明的一类优选的化合物具有式1所示的结构，其中X和Y各自独立地为氮，氧或硫，X可以进一步为碳，R 1， -R 4是氢，当X是氮时，R 2是氢，但当X是硫或氧时，R 2不是存在的，R 4是氢 当Y为氮时，当Y为硫或氧时不存在，R 1和R 3各自独立地为取代或未取代的烷基，卤代烷基，环烷基，芳基，酰基 ，或杂环，或其代谢产物或降解产物。
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