Method for preparing acyclovir 2/3 hydrate
    2.
    发明授权
    Method for preparing acyclovir 2/3 hydrate 有权
    制备阿昔洛韦2/3水合物的方法

    公开(公告)号:US09084792B2

    公开(公告)日:2015-07-21

    申请号:US13259466

    申请日:2010-03-17

    IPC分类号: C07D473/18 A61K31/522

    CPC分类号: A61K31/522 C07D473/18

    摘要: Preparation of acyclovir 2/3 hydrate comprises mixing acyclovir with water at weight ratio of 1:5˜50, dissolving at 50˜100° C., filtering, cooling filtrate at 0˜30° C. to precipitate crystal, collecting the crystal by filtration, and drying the crystal at 0˜150° C. for 0.5˜24 hours to obtain acyclovir 2/3 hydrate. The preparation process is simple and suitable for industrial production. The prepared product has good and stable crystal form.

    摘要翻译: 阿昔洛韦2/3水合物的制备包括将阿昔洛韦与水的重量比为1:5〜50混合,在50〜100℃下溶解,过滤,在0〜30℃下冷却滤液,使晶体析出,收集晶体, 过滤,并在0〜150℃干燥晶体0.5〜24小时,得到无环鸟苷2/3水合物。 制备工艺简单,适合工业生产。 制备的产品具有良好稳定的晶体形式。