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    METHODS FOR RAPIDLY IDENTIFYING SMALL ORGANIC MOLECULE LIGANDS FOR BINDING TO BIOLOGICAL TARGET MOLECULES
    1.
    发明申请
    METHODS FOR RAPIDLY IDENTIFYING SMALL ORGANIC MOLECULE LIGANDS FOR BINDING TO BIOLOGICAL TARGET MOLECULES 审中-公开
    用于快速鉴定用于结合生物目标分子的小有机分子配体的方法

    公开(公告)号：US20100022399A1

    公开(公告)日：2010-01-28

    申请号：US12571629

    申请日：2009-10-01

    申请人： Jim Wells ,  Dan Erlanson ,  Andrew C. Braisted

    发明人： Jim Wells ,  Dan Erlanson ,  Andrew C. Braisted

    IPC分类号： C40B20/08 ,  C40B20/00

    CPC分类号： G01N33/566 ,  G01N33/53 ,  Y10T436/24

    摘要： The present invention is directed to novel methods for rapidly and unambiguously identifying small organic molecule ligands for binding to biological target molecules. Small organic molecule ligands identified according to the methods of the present invention may find use, for example, as novel therapeutic drug lead compounds, enzyme inhibitors, labeling compounds, diagnostic reagents, affinity reagents for protein purification, and the like. Also presented are novel methods for identifying high affinity binding ligands for a biological target molecule of interest, wherein those methods comprise linking two or more small organic molecule ligands previously identified as being capable of binding to the biological target molecule of interest. Biological target molecules include, for example, polypeptides, nucleic acids, carbohydrates, nucleoproteins, glycoproteins, glycolipids and lipoproteins.

    摘要翻译： 本发明涉及用于快速且明确地鉴定用于结合生物靶分子的小有机分子配体的新方法。 根据本发明方法鉴定的小有机分子配体可用于例如新型治疗药物铅化合物，酶抑制剂，标记化合物，诊断试剂，用于蛋白质纯化的亲和试剂等。 还提出了用于鉴定感兴趣的生物靶分子的高亲和力结合配体的新方法，其中这些方法包括将先前鉴定为能够结合目的生物靶标分子的两个或更多个小有机分子配体连接。 生物靶分子包括例如多肽，核酸，碳水化合物，核蛋白，糖蛋白，糖脂和脂蛋白。

    Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
    4.
    发明授权
    Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules 失效
    用于快速鉴定结合生物靶分子的小有机分子配体的方法

    公开(公告)号：US06811966B2

    公开(公告)日：2004-11-02

    申请号：US10043833

    申请日：2002-01-11

    申请人： Jim Wells ,  Dan Erlanson ,  Andrew C. Braisted

    发明人： Jim Wells ,  Dan Erlanson ,  Andrew C. Braisted

    IPC分类号： C12Q100

    CPC分类号： G01N33/566 ,  G01N33/53 ,  Y10T436/24

    摘要： The present invention is directed to novel methods for rapidly and unambiguously identifying small organic molecule ligands for binding to biological target molecules. Small organic molecule ligands identified according to the methods of the present invention may find use, for example, as novel therapeutic drug lead compounds, enzyme inhibitors, labeling compounds, diagnostic reagents, affinity reagents for protein purification, and the like. Also presented are novel methods for identifying high affinity binding ligands for a biological target molecule of interest, wherein those methods comprise linking two or more small organic molecule ligands previously identified as being capable of binding to the biological target molecule of interest. Biological target molecules include, for example, polypeptides, nucleic acids, carbohydrates, nucleoproteins, glycoproteins, glycolipids and lipoproteins.

    摘要翻译： 本发明涉及用于快速且明确地鉴定用于结合生物靶分子的小有机分子配体的新方法。 根据本发明方法鉴定的小有机分子配体可用于例如新型治疗药物铅化合物，酶抑制剂，标记化合物，诊断试剂，用于蛋白质纯化的亲和试剂等。 还提出了用于鉴定感兴趣的生物靶分子的高亲和力结合配体的新方法，其中这些方法包括将先前鉴定为能够结合目的生物靶标分子的两个或更多个小有机分子配体连接。 生物靶分子包括例如多肽，核酸，碳水化合物，核蛋白，糖蛋白，糖脂和脂蛋白。

    Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
    5.
    发明授权
    Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules 失效

    公开(公告)号：US06335155B1

    公开(公告)日：2002-01-01

    申请号：US09105372

    申请日：1998-06-26

    申请人： Jim Wells ,  Dan Erlanson ,  Andrew C. Braisted

    发明人： Jim Wells ,  Dan Erlanson ,  Andrew C. Braisted

    IPC分类号： C12Q100

    CPC分类号： G01N33/566 ,  G01N33/53 ,  Y10T436/24

    摘要： The present invention is directed to novel methods for rapidly and unambiguously identifying small organic molecule ligands for binding to biological target molecules. Small organic molecule ligands identified according to the methods of the present invention may find use, for example, as novel therapeutic drug lead compounds, enzyme inhibitors, labeling compounds, diagnostic reagents, affinity reagents for protein purification, and the like. Also presented are novel methods for identifying high affinity binding ligands for a biological target molecule of interest, wherein those methods comprise linking two or more small organic molecule ligands previously identified as being capable of binding to the biological target molecule of interest. Biological target molecules include, for example, polypeptides, nucleic acids, carbohydrates, nucleoproteins, glycoproteins, glycolipids and lipoproteins.

    Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
    8.
    发明申请
    Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules 审中-公开
    用于快速鉴定结合生物靶分子的小有机分子配体的方法

    公开(公告)号：US20070026451A1

    公开(公告)日：2007-02-01

    申请号：US11540883

    申请日：2006-09-28

    申请人： Jim Wells ,  Dan Erlanson ,  Andrew Braisted

    发明人： Jim Wells ,  Dan Erlanson ,  Andrew Braisted

    IPC分类号： C40B30/06 ,  C40B40/08 ,  C40B40/10

    CPC分类号： G01N33/566 ,  G01N33/53 ,  Y10T436/24

    摘要： The present invention is directed to novel methods for rapidly and unambiguously identifying small organic molecule ligands for binding to biological target molecules. Small organic molecule ligands identified according to the methods of the present invention may find use, for example, as novel therapeutic drug lead compounds, enzyme inhibitors, labeling compounds, diagnostic reagents, affinity reagents for protein purification, and the like. Also presented are novel methods for identifying high affinity binding ligands for a biological target molecule of interest, wherein those methods comprise linking two or more small organic molecule ligands previously identified as being capable of binding to the biological target molecule of interest. Biological target molecules include, for example, polypeptides, nucleic acids, carbohydrates, nucleoproteins, glycoproteins, glycolipids and lipoproteins.

    摘要翻译： 本发明涉及用于快速且明确地鉴定用于结合生物靶分子的小有机分子配体的新方法。 根据本发明方法鉴定的小有机分子配体可用于例如新型治疗药物铅化合物，酶抑制剂，标记化合物，诊断试剂，用于蛋白质纯化的亲和试剂等。 还提出了用于鉴定感兴趣的生物靶分子的高亲和力结合配体的新方法，其中这些方法包括将先前鉴定为能够结合目的生物靶标分子的两个或更多个小有机分子配体连接。 生物靶分子包括例如多肽，核酸，碳水化合物，核蛋白，糖蛋白，糖脂和脂蛋白。