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公开(公告)号：US20130030528A1
公开(公告)日：2013-01-31
申请号：US13537194
申请日：2012-06-29
IPC分类号： A61F2/02
CPC分类号： A61F2/30756 , A61B17/1604 , A61B17/1635 , A61B17/1675 , A61F2/28 , A61F2/30749 , A61F2/3094 , A61F2/38 , A61F2/3859 , A61F2/4644 , A61F2002/2817 , A61F2002/2839 , A61F2002/30004 , A61F2002/30224 , A61F2002/30235 , A61F2002/30751 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/4646 , A61F2002/4648 , A61F2002/4649 , A61F2230/0069 , A61F2250/0014 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/3804 , A61L2430/06
摘要： The invention is directed towards a process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage graft with recipient tissue. The invention is also directed towards a process for repairing a cartilage defect and implanting a cartilage graft into a human or animal. The invention is further directed toward a repaired cartilage defect.
摘要翻译： 本发明涉及将软骨移植物植入软骨缺损并用接受者组织密封植入的软骨移植物的方法。 本发明还涉及修复软骨缺损并将软骨移植物植入人或动物的方法。 本发明进一步针对修复的软骨缺损。
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2.发明授权Knitted biodegradable silk fabric comprising yarn promoting ingrowth of cells and methods of making 有权针织生物降解丝织物，包括促进细胞向内生长的纱线和制造方法公开(公告)号：US08633027B2
公开(公告)日：2014-01-21
申请号：US13071380
申请日：2011-03-24
CPC分类号： A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要： Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
摘要翻译： 丝被纯化以消除免疫原性成分（特别是丝胶蛋白），并且用于形成用于形成用于植入的组织支撑假体装置的织物。 织物可以携带官能团，药物和其他生物试剂。 应用包括疝修补，组织壁重建和器官支撑，如膀胱吊带。 丝纤维平行布置，并且任选地缠结（例如扭曲）以形成构造体; 可以在织物形成期间的任何点提取丝胶蛋白，留下具有优异拉伸强度和其它机械性能的丝素蛋白纤维构建体。
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3.发明授权Methods for making biocompatible, implantable, substantially sericin free silk fabric 有权制造生物相容的，可植入的，基本上无丝蛋白的丝织物的方法公开(公告)号：US08685426B2
公开(公告)日：2014-04-01
申请号：US13456860
申请日：2012-04-26
CPC分类号： A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要： Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
摘要翻译： 丝被纯化以消除免疫原性成分（特别是丝胶蛋白），并且用于形成用于形成用于植入的组织支撑假体装置的织物。 织物可以携带官能团，药物和其他生物试剂。 应用包括疝修补，组织壁重建和器官支撑，如膀胱吊带。 丝纤维平行布置，并且任选地缠结（例如扭曲）以形成构造体; 可以在织物形成期间的任何点提取丝胶蛋白，留下具有优异拉伸强度和其它机械性能的丝素蛋白纤维构建体。
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4.发明授权Method of forming an implantable knitted fabric comprising silk fibroin fibers 有权形成包含丝素蛋白纤维的可植入针织物的方法公开(公告)号：US08628791B2
公开(公告)日：2014-01-14
申请号：US13071396
申请日：2011-03-24
CPC分类号： A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要： Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
摘要翻译： 丝被纯化以消除免疫原性成分（特别是丝胶蛋白），并且用于形成用于形成用于植入的组织支撑假体装置的织物。 织物可以携带官能团，药物和其他生物试剂。 应用包括疝修补，组织壁重建和器官支撑，如膀胱吊带。 丝纤维平行布置，并且任选地缠结（例如扭曲）以形成构造体; 可以在织物形成期间的任何点提取丝胶蛋白，留下具有优异拉伸强度和其它机械性能的丝素蛋白纤维构建体。
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