专利检索 ap:"Rebecca L. Horan" 第 1 页

1.

发明授权
Silk fibroin hydrogels and uses thereof 有权
标题翻译：丝素蛋白水凝胶及其用途

公开(公告)号：US09005606B2

公开(公告)日：2015-04-14

申请号：US13420334

申请日：2012-03-14

申请人： Gregory H. Altman , Rebecca L. Horan , Adam L. Collette , Jingsong Chen

发明人： Gregory H. Altman , Rebecca L. Horan , Adam L. Collette , Jingsong Chen

IPC分类号： A61F2/10 , A61K35/12 , A61P43/00 , C08B37/08 , A61K38/17 , A61K47/42 , A61L27/22 , A61L27/26 , A61L27/52 , A61K8/64 , A61Q19/00 , A61F2/12

CPC分类号： A61F2/12 , A61K8/64 , A61K38/1767 , A61K47/42 , A61K2800/5922 , A61K2800/91 , A61L27/227 , A61L27/26 , A61L27/52 , A61L2430/34 , A61Q19/00 , C08B37/0072 , C08L89/00

摘要： The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such molecules, methods of making fibroin hydrogels, fibroin hydrogels and fibroin hydrogel formulations useful for a variety of medical uses, including, without limitation uses as bulking agents, tissue space fillers, templates for tissue reconstruction or regeneration, cell culture scaffolds for tissue engineering and for disease models, surface coating to improve medical device function, or drug delivery devices.

摘要翻译： 本说明书提供了用于纯化丝心蛋白，纯化的丝心蛋白，将生物和合成分子与丝心蛋白缀合的方法，与此类分子缀合的丝心蛋白，制备丝心蛋白水凝胶的方法，丝心蛋白水凝胶和用于各种医疗用途的丝心蛋白水凝胶制剂的方法，包括，但不限于用作填充剂，组织空间填充剂，用于组织重建或再生的模板，用于组织工程和疾病模型的细胞培养支架，用于改善医疗装置功能的表面涂层或药物递送装置。

2.

发明授权
Compositions and soft tissue replacement methods 有权
标题翻译：组合物和软组织替代方法

公开(公告)号：US08894992B2

公开(公告)日：2014-11-25

申请号：US13398680

申请日：2012-02-16

申请人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im

发明人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im

IPC分类号： A61F2/20 , A01N63/00 , A61K8/44 , A61K8/64 , A61K35/12 , A61Q19/00 , A61K31/195 , A61K8/98 , A61K31/4025 , A61L27/40 , A61K35/64

CPC分类号： A61K31/4025 , A61K8/44 , A61K8/64 , A61K8/981 , A61K31/195 , A61K35/35 , A61K35/63 , A61K38/1767 , A61L27/40 , A61Q19/00 , A61K2300/00

摘要： The invention relates to compositions comprising adipose tissue, a silk fibroin material and a compound of the structure The composition is administered to a site of a soft tissue condition including those of breast tissue. The silk fibroin material can be in the form of a silk hydrogel, a silk film, a silk scaffold, a silk sheet, a silk porous material, a silk fiber or a combination of those materials. The silk material may be substantially sericin free.

摘要翻译： 本发明涉及包含脂肪组织，丝素蛋白材料和结构化合物的组合物。将组合物施用于包括乳腺组织的软组织病症的部位。丝素蛋白材料可以是丝素水凝胶，丝膜，丝绸支架，丝
绸，丝绸多孔材料，丝纤维或这些材料的组合的形式。丝质材料可以基本上不含丝氨酸。

3.

发明申请
COMPOSITIONS AND IMPROVED SOFT TISSUE REPLACEMENT METHODS 有权

公开(公告)号：US20120213852A1

公开(公告)日：2012-08-23

申请号：US13398661

申请日：2012-02-16

申请人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im

发明人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im

IPC分类号： A61K9/00 , A61P1/04 , A61P13/00 , A61P1/00 , A61K35/12 , A61P17/00

CPC分类号： A61K31/381 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/4986 , A61K8/64 , A61K8/981 , A61K31/4015 , A61K31/4025 , A61K31/45 , A61K35/35 , A61K38/1767 , A61K45/06 , A61Q19/00 , A61K2300/00

摘要： The specification discloses compositions and methods for treating a soft tissue defect of an individual.

4.

发明申请
Silk Fibroin Hydrogels and Uses Thereof 审中-公开

公开(公告)号：US20110020409A1

公开(公告)日：2011-01-27

申请号：US12764043

申请日：2010-04-20

申请人： Gregory H. Altman , Rebecca L. Horan , Adam L. Collette , Jingsong Chen

发明人： Gregory H. Altman , Rebecca L. Horan , Adam L. Collette , Jingsong Chen

IPC分类号： A61K38/00 , A61K9/00 , A61K38/06 , A61K38/16 , A61K38/08 , A61K38/10 , A61P41/00

CPC分类号： A61F2/12 , A61K8/64 , A61K38/1767 , A61K47/42 , A61K2800/5922 , A61K2800/91 , A61L27/227 , A61L27/26 , A61L27/52 , A61L2430/34 , A61Q19/00 , C08B37/0072 , C08L89/00

摘要： The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such molecules, methods of making fibroin hydrogels, fibroin hydrogels and fibroin hydrogel formulations useful for a variety of medical uses, including, without limitation uses as bulking agents, tissue space fillers, templates for tissue reconstruction or regeneration, cell culture scaffolds for tissue engineering and for disease models, surface coating to improve medical device function, or drug delivery devices.

5.

发明申请
Silk Fibroin Hydrogels and Uses Thereof 审中-公开

公开(公告)号：US20110014287A1

公开(公告)日：2011-01-20

申请号：US12764052

申请日：2010-04-20

申请人： Gregory H. Altman , Rebecca L. Horan , Adam L. Collette , Jingsong Chen

发明人： Gregory H. Altman , Rebecca L. Horan , Adam L. Collette , Jingsong Chen

IPC分类号： A61K9/00 , A61K31/167 , A61P17/00 , A61Q19/00

CPC分类号： A61F2/12 , A61K8/64 , A61K38/1767 , A61K47/42 , A61K2800/5922 , A61K2800/91 , A61L27/227 , A61L27/26 , A61L27/52 , A61L2430/34 , A61Q19/00 , C08B37/0072 , C08L89/00

摘要： The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such molecules, methods of making fibroin hydrogels, fibroin hydrogels and fibroin hydrogel formulations useful for a variety of medical uses, including, without limitation uses as bulking agents, tissue space fillers, templates for tissue reconstruction or regeneration, cell culture scaffolds for tissue engineering and for disease models, surface coating to improve medical device function, or drug delivery devices.

6.

发明申请
PROSTHETIC FABRIC STRUCTURE 审中-公开
标题翻译：预制织物结构

公开(公告)号：US20110009960A1

公开(公告)日：2011-01-13

申请号：US12814037

申请日：2010-06-11

申请人： Gregory H. Altman , Jingsong Chen , Rebecca L. Horan , David J. Horan

发明人： Gregory H. Altman , Jingsong Chen , Rebecca L. Horan , David J. Horan

IPC分类号： A61F2/12

CPC分类号： A61F2/0063 , A61F2/0059 , A61F2/12 , A61F2210/0004 , A61F2220/0008 , A61L27/227 , A61L27/3604 , A61L27/3843 , A61L27/48 , A61L27/54 , A61L2300/25 , A61L2300/414 , A61L2430/04 , D01F4/02 , C08L89/00

摘要： Disclosed herein is an implantable prosthesis for breast augmentation or reconstruction procedures. The prosthesis comprises a biocompatible and biodegradable fabric structure comprising one or more individual yarns comprised of sericin-extracted native fibroin fibers, wherein the yarns are intertwined to produce the fabric structure. The fabric structure extends in at least a first dimension and has at least a first surface that is adapted to engage and support natural breast tissue and/or a prosthetic breast implant in a patient. Also disclosed are methods of supporting breast tissue or a breast implant in a patient by inserting the prosthesis between the skin of the patient and the breast tissue and/or implant within the patient.

摘要翻译： 本文公开了一种用于隆胸或重建手术的可植入假体。假体包括生物相容性和可生物降解的织物结构，其包括由丝胶提取的天然丝心蛋白纤维组成的一个或多个单独纱线，其中纱线缠结以产生织物结构。织物结构在至少第一维度上延伸并且具有至少第一表面，其适于接合和支撑患者中的天然乳房组织和/或假体乳房植入物。还公开了通过将假体插入患者的皮肤和患者体内的乳房组织和/或植入物之间来支持患者的乳房组织或乳房植入物的方法。

7.

发明申请
Silk Fibroin Hydrogels and Uses Thereof 审中-公开
标题翻译：丝素蛋白水凝胶及其用途

公开(公告)号：US20110008406A1

公开(公告)日：2011-01-13

申请号：US12764050

申请日：2010-04-20

申请人： Gregory H. Altman , Rebecca L. Horan , Adam L. Collette , Jingsong Chen , Dennis VanEpps

发明人： Gregory H. Altman , Rebecca L. Horan , Adam L. Collette , Jingsong Chen , Dennis VanEpps

IPC分类号： A61F2/10 , A61K31/167 , A61K35/12 , A61P9/06 , A61P23/02 , A61P41/00 , A61F2/52

CPC分类号： A61F2/12 , A61K8/64 , A61K38/1767 , A61K47/42 , A61K2800/5922 , A61K2800/91 , A61L27/227 , A61L27/26 , A61L27/52 , A61L2430/34 , A61Q19/00 , C08B37/0072 , C08L89/00

摘要： The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such molecules, methods of making fibroin hydrogels, fibroin hydrogels and fibroin hydrogel formulations useful for a variety of medical uses, including, without limitation uses as bulking agents, tissue space fillers, templates for tissue reconstruction or regeneration, cell culture scaffolds for tissue engineering and for disease models, surface coating to improve medical device function, or drug delivery devices.

摘要翻译： 本说明书提供了用于纯化丝心蛋白，纯化的丝心蛋白，将生物和合成分子与丝心蛋白缀合的方法，与此类分子缀合的丝心蛋白，制备丝心蛋白水凝胶的方法，丝心蛋白水凝胶和用于各种医疗用途的丝心蛋白水凝胶制剂的方法，包括，但不限于用作填充剂，组织空间填充剂，用于组织重建或再生的模板，用于组织工程和疾病模型的细胞培养支架，用于改善医疗装置功能的表面涂层或药物递送装置。

8.

发明授权
Compositions and soft tissue replacement methods 有权
标题翻译：组合物和软组织替代方法

公开(公告)号：US08900571B2

公开(公告)日：2014-12-02

申请号：US13398674

申请日：2012-02-16

申请人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im

发明人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im

IPC分类号： A01N63/00 , A61F2/20 , A61K8/49 , A61K8/64 , A61K31/5377 , A61K31/519 , A61K31/4025 , A61K8/98 , A61Q19/00 , A61K38/17 , A61K35/12

CPC分类号： A61K31/4025 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/4986 , A61K8/64 , A61K8/981 , A61K31/519 , A61K31/5377 , A61K35/35 , A61K38/1767 , A61Q19/00 , A61K2300/00

摘要： The invention relates to compositions comprising a silk fibroin material, adipose tissue and a compound of the structure where X1 and X5 are independently CH or N; X7 is NH, O or S; X8 and X9 are independently CH or N; R13 is an optionally substituted aryl or optionally substituted heteroaryl and R14 is C1-6 alkyl, optionally substituted aryl or optionally substituted heteroaryl. The composition is administered to a site of a soft tissue condition including those of breast tissue. The silk fibroin material can be in the form of a silk hydrogel, a silk film, a silk scaffold, a silk sheet, a silk porous material or a silk fiber. The silk fibroin material can be substantially sericin free.

摘要翻译： 本发明涉及包含丝素蛋白材料，脂肪组织和其中X1和X5独立地为CH或N的结构的化合物的组合物; X7是NH，O或S; X8和X9独立地为CH或N; R13是任选取代的芳基或任选取代的杂芳基，R 14是C 1-6烷基，任选取代的芳基或任选取代的杂芳基。将组合物施用于包括乳房组织的组织状况的部位。丝素蛋白材料可以是丝素水凝胶，丝膜，丝绸支架，丝绸片，丝多孔材料或丝纤维的形式。丝素蛋白材料可以基本上不含丝胶蛋白。