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    HARVESTING BONE GRAFT MATERIAL FOR USE IN SPINAL AND OTHER BONE FUSION SURGERIES
    2.
    发明申请
    HARVESTING BONE GRAFT MATERIAL FOR USE IN SPINAL AND OTHER BONE FUSION SURGERIES 审中-公开
    用于脊柱和其他骨融合手术的骨折材料

    公开(公告)号：US20160113780A1

    公开(公告)日：2016-04-28

    申请号：US14688544

    申请日：2015-04-16

    申请人： Seth L. Neubardt

    发明人： Seth L. Neubardt

    IPC分类号： A61F2/44 ,  A61B17/32 ,  A61B17/16

    CPC分类号： A61F2/4601 ,  A61B17/1635 ,  A61B17/1671 ,  A61B17/320068 ,  A61B2017/320072 ,  A61F2/442 ,  A61F2/4455 ,  A61F2/4611 ,  A61F2/4644 ,  A61F2002/30471 ,  A61F2002/30845 ,  A61F2002/445 ,  A61F2002/4648 ,  A61F2002/4649

    摘要： A system for harvesting bone graft material for use during bone fusion surgery. In one embodiment, a bone cutting tool has a blade fixed on a distal end of a shaft. The distal end of the shaft is pivoted on a cage set between two bones to be fused, and the blade is activated to cut into the bones and form a solid bone segment in each bone as the tool shaft turns. A paddle is arranged to be inserted between the bones, and to displace the cut bone segments so that a leading portion of each segment enters the bone opposite the bone from which the segment was cut, a central portion of the segment spans across the bones, and a trailing portion of the segment remains in the bone from which it was cut. The displaced segments act as strut grafts to fuse the bones to one another.

    摘要翻译： 骨融合手术期间采集骨移植材料的系统。 在一个实施例中，骨切割工具具有固定在轴的远端上的刀片。 轴的远端在两个骨头之间的笼子上枢转以被熔化，并且刀片被激活以切割成骨骼，并且随着工具轴转动而在每个骨中形成固体骨段。 桨被布置成插入骨头之间，并且移动切割的骨段，使得每个段的前导部分进入与骨骼切割的骨相对的骨，该段的中心部分跨越骨骼， 并且该段的尾部保留在被切割的骨中。 移位的部分作为支柱移植物将骨骼彼此融合。

    Differentiation of adipose stromal cells into osteoblasts and treating bones
    3.
    发明授权
    Differentiation of adipose stromal cells into osteoblasts and treating bones 有权
    脂肪基质细胞分化为成骨细胞和治疗骨骼

    公开(公告)号：US09200255B2

    公开(公告)日：2015-12-01

    申请号：US11656571

    申请日：2007-01-23

    申请人： Yuan-di C. Halvorsen

    发明人： Yuan-di C. Halvorsen

    IPC分类号： C12N5/077 ,  A61F2/28 ,  A61F2/30 ,  A61F2/46 ,  A61K35/12 ,  A61K38/00 ,  A61K48/00

    CPC分类号： C12N5/0654 ,  A61F2/28 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30678 ,  A61F2002/4648 ,  A61F2310/00293 ,  A61F2310/00365 ,  A61F2310/00383 ,  A61K35/12 ,  A61K35/32 ,  A61K38/00 ,  A61K48/00 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2500/42 ,  C12N2501/155 ,  C12N2502/1305 ,  C12N2506/13 ,  C12N2506/1384 ,  C12N2510/00 ,  C12N2533/14 ,  C12N2533/54

    摘要： The invention provides methods and compositions for differentiating stromal cells from adipose tissue into cells having osteoblastic properties, and methods for improving a subject's bone structure. The methods comprise culturing stromal cells from adipose tissue in β-glycerophosphate and ascorbic acid and/or ascorbate-2-phosphate for a time sufficient to allow differentiation of said cells into osteoblasts. Such methods and compositions are useful in the production of osteoblasts for autologous transplantation into bone at a surgical site or injury. The compositions comprise adipose stromal cells, a medium capable of supporting the growth of fibroblasts and amounts of β-glycerophosphate and ascorbic acid and/or ascorbic-2 phosphate sufficient to induce the differentiation of said stromal cells into osteoblasts.The invention further provides methods of identifying compounds that affect osteoblast differentiation. Such compounds are useful in the study of bone development and in the treatment of bone disorders, including bone fractures and osteoporosis.

    摘要翻译： 本发明提供了用于将基质细胞与脂肪组织分化成具有成骨细胞特性的细胞的方法和组合物，以及用于改善受试者骨结构的方法。 所述方法包括从甘油磷酸酯和抗坏血酸和/或抗坏血酸-2-磷酸酯中的脂肪组织培养基质细胞足够的时间，以允许将所述细胞分化成成骨细胞。 这些方法和组合物可用于在外科手术部位或损伤处自体移植到骨中的成骨细胞的生产。 所述组合物包含脂肪基质细胞，能够支持成纤维细胞生长的培养基和足以诱导所述基质细胞分化成成骨细胞的量的甘油磷酸酯和抗坏血酸和/或抗坏血酸-2-磷酸酯的量的培养基。 本发明还提供鉴定影响成骨细胞分化的化合物的方法。 这些化合物可用于研究骨发育和治疗骨骼疾病，包括骨折和骨质疏松症。

    Method of preparing a poorly crystalline calcium phosphate and methods of its use
    7.
    发明授权
    Method of preparing a poorly crystalline calcium phosphate and methods of its use 失效
    制备结晶不良的磷酸钙的方法及其使用方法

    公开(公告)号：US07517539B1

    公开(公告)日：2009-04-14

    申请号：US09284297

    申请日：1997-10-16

    申请人： Dosuk D. Lee ,  Christian Rey ,  Maria Aiolova ,  Aliassghar Tofighi

    发明人： Dosuk D. Lee ,  Christian Rey ,  Maria Aiolova ,  Aliassghar Tofighi

    IPC分类号： A61K47/04

    CPC分类号： A61F2/28 ,  A61F2/30756 ,  A61F2002/30062 ,  A61F2002/30762 ,  A61F2002/4648 ,  A61F2210/0004 ,  A61F2310/00293 ,  A61K9/2009 ,  A61L24/02 ,  A61L27/12 ,  A61L27/38 ,  A61L27/42 ,  A61L27/425 ,  A61L27/48 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/256 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/44 ,  A61L2300/452 ,  A61L2400/06 ,  A61L2430/02 ,  C01B25/16 ,  C01B25/32 ,  C01B25/321 ,  C01B25/325 ,  Y02P30/48

    摘要： The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite. The supplemental material may be biocompatible, bioresorbable or non-resorbable. A method for treating a bone defect also is provided by identifying a bone site suitable for receiving an implant, and introducing a strongly resorbable, poorly crystalline apatitic calcium phosphate at the implant site, whereby bone is formed at the implant site. The implant site may be a variety of sites, such as a tooth socket, non-union bone, bone prosthesis, an osteoporotic bone, an intervertebral space, an alveolar ridge or a bone fracture.

    摘要翻译： 本发明提供了一种用于生产与吸热反应相关的以温度依赖的方式硬化的磷酸钙水泥或填料的新方法。 在反应中，将有限量的水与干燥的磷酸钙前体混合以产生水合前体浆料。 糊状物的硬化在体温下快速发生，伴随着一种或多种反应物转化为结晶不良的磷灰石磷酸钙。 本发明的硬化水泥，填料，生长基质，矫形和递送装置可快速吸收并刺激硬组织的生长和愈合。 提供了一种复合材料，其包括强生物可再吸收，结晶不良的磷灰石复合材料和补充材料。 补充材料与羟基磷灰石材料紧密接触，其量有效地赋予复合材料所选择的特性。 补充材料可以是生物相容的，生物可再吸收的或不可再吸收的。 通过鉴定适于接收植入物的骨部位，以及在植入部位引入强吸收不良结晶的磷灰石磷酸钙，从而在植入部位形成骨，提供了治疗骨缺损的方法。 植入部位可以是各种部位，例如牙槽，非联合骨，骨假体，骨质疏松的骨，椎间隙，牙槽嵴或骨折。

    Implantation of cartilage
    8.
    发明申请
    Implantation of cartilage 审中-公开
    植入软骨

    公开(公告)号：US20090024224A1

    公开(公告)日：2009-01-22

    申请号：US11826530

    申请日：2007-07-16

    申请人： Silvia S. Chen ,  Xiaofei Qin ,  Jingsong Chen ,  Lloyd Wolfinbarger, JR.

    发明人： Silvia S. Chen ,  Xiaofei Qin ,  Jingsong Chen ,  Lloyd Wolfinbarger, JR.

    IPC分类号： A61F2/02 ,  A61F2/28

    CPC分类号： A61F2/30756 ,  A61B17/1604 ,  A61B17/1635 ,  A61B17/1675 ,  A61F2/28 ,  A61F2/30749 ,  A61F2/3094 ,  A61F2/38 ,  A61F2/3859 ,  A61F2/4644 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30004 ,  A61F2002/30224 ,  A61F2002/30235 ,  A61F2002/30751 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/4646 ,  A61F2002/4648 ,  A61F2002/4649 ,  A61F2230/0069 ,  A61F2250/0014 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/3804 ,  A61L2430/06

    摘要： The invention is directed towards a process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage graft with recipient tissue by creating a first bore down to the bone portion of the cartilage defect, creating a second shaped bore that is concentric to and on top of the first bore to match the shape and size of the cartilage graft, treating the first bore and the second shaped bore at the defect site with a bonding agent, treating the circumferential area of the cartilage graft with a bonding agent, inserting the cartilage graft into the defect site and wherein the superficial surface of the cartilage graft is at the same height as the surrounding cartilage surface. The first and second bonding agents may be activated by applying a stimulation agent to induce sealing, integration, and restoration of the hydrodynamic environments of the recipient tissue. The invention is also directed towards a process for repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, cleaning and disinfecting the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation. The devitalized cartilage graft is also optionally stored between the removing cellular debris and the recellularizing steps. The invention is further directed toward a repaired cartilage defect.

    摘要翻译： 本发明涉及一种用于将软骨移植物植入软骨缺损并通过产生向下到软骨缺损的骨部分的第一孔的方式将植入的软骨移植物与受体组织密封的方法，产生与软骨缺损同心的第二形状的孔 在第一孔的顶部，以匹配软骨移植物的形状和尺寸，用粘合剂处理缺损部位处的第一孔和第二形状孔，用粘合剂处理软骨移植物的周边区域， 软骨移植到缺损部位，其中软骨移植物的表面与周围的软骨表面处于相同的高度。 可以通过施加刺激剂来诱导第一和第二粘合剂来诱导受体组织的流体动力学环境的密封，整合和恢复。 本发明还涉及一种修复软骨缺损并将软骨移植物植入人或动物的方法，该软骨移植物通过将软骨基质制成单独的移植物，清洁和消毒软骨移植物，将预处理溶液施用于软骨移植物，去除细胞 碎片使用提取溶液以产生失活的软骨移植物，将软骨移植物植入软骨缺损带有或不具有插入装置，以及用接受者组织密封植入的软骨移植物。 灭活的软骨移植物任选地在体外，体内或原位与活细胞接触，以在植入之前或之后使组织至关重要。 灭活的软骨移植物也任选地存储在去除细胞碎片和再结晶步骤之间。 本发明进一步针对修复的软骨缺损。

    Cleaning and devitalization of cartilage
    9.
    发明申请
    Cleaning and devitalization of cartilage 审中-公开
    软骨的清洁和失活

    公开(公告)号：US20080077251A1

    公开(公告)日：2008-03-27

    申请号：US11826522

    申请日：2007-07-16

    申请人： Silvia Chen ,  Xiaofei Qin ,  Jingsong Chen ,  Lloyd Wolfinbarger

    发明人： Silvia Chen ,  Xiaofei Qin ,  Jingsong Chen ,  Lloyd Wolfinbarger

    IPC分类号： A61F2/02 ,  C12N5/08

    CPC分类号： A61F2/30756 ,  A01N1/02 ,  A01N1/0215 ,  A61F2/28 ,  A61F2/30749 ,  A61F2/3094 ,  A61F2/38 ,  A61F2/3859 ,  A61F2/4644 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30004 ,  A61F2002/30224 ,  A61F2002/30751 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/4646 ,  A61F2002/4648 ,  A61F2002/4649 ,  A61F2230/0069 ,  A61F2250/0014 ,  A61L2/0088 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/38 ,  A61L2430/06 ,  A61L2430/40

    摘要： The invention is further directed to producing a cleaned, disinfected, and devitalized cartilage graft by optionally cleaning and disinfecting the cartilage graft; treating the cartilage graft in a pretreatment solution; treating the cartilage graft in an extracting solution; washing the extracted cartilage graft with a rinsing solution; and subsequently soaking the devitalized cartilage graft in a storage solution. The devitalized cartilage graft is essentially free from metabolically viable and/or reproductively viable cells and the rinsing solution is hypotonic solution or isotonic solution. The present invention is further directed to a cleaned, disinfected, and devitalized cartilage graft and a process for cleaning, disinfecting, and devitalizing cartilage grafts. The invention also relates to a process for repairing a cartilage defect and implantation of a cartilage graft into a human or animal by crafting the cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation. The devitalized cartilage graft is also optionally stored between the removing cellular debris and the recellularizing steps.

    摘要翻译： 本发明进一步旨在通过任选地清洁和消毒软骨移植物来生产清洁的，消毒的和失活的软骨移植物; 在预处理溶液中处理软骨移植物; 在提取液中处理软骨移植物; 用冲洗溶液洗涤提取的软骨移植物; 随后将失活的软骨移植物浸泡在储存溶液中。 失活的软骨移植物基本上没有代谢活力和/或再生活细胞，冲洗溶液是低渗溶液或等渗溶液。 本发明还涉及清洁，消毒和失活的软骨移植物以及用于清洁，消毒和失活软骨移植物的方法。 本发明还涉及一种通过将软骨基质成形为单独的移植物，消毒和清洁软骨移植物，将预处理溶液施用于软骨移植物，去除细胞的方法来修复软骨缺损和软骨移植物植入人或动物的方法 碎片使用提取溶液以产生失活的软骨移植物，将软骨移植物植入软骨缺损带有或不具有插入装置，以及用接受者组织密封植入的软骨移植物。 灭活的软骨移植物任选地在体外，体内或原位与活细胞接触，以在植入之前或之后使组织至关重要。 灭活的软骨移植物也任选地存储在去除细胞碎片和再结晶步骤之间。