公开(公告)号：US20240245829A1

公开(公告)日：2024-07-25

申请号：US18591564

申请日：2024-02-29

申请人： Musculoskeletal Transplant Foundation

发明人： Michael A. Nasert ,  Florence Stoffel ,  Paul R. Williams ,  Alex Callahan

IPC分类号： A61L27/36 ,  B29B13/04 ,  B29C65/56 ,  B29L31/00

CPC分类号： A61L27/3612 ,  A61L27/3654 ,  B29B13/04 ,  B29C65/565 ,  A61L2430/06 ,  B29K2995/0056 ,  B29L2031/7532

摘要： Elongated, curled cartilage fibers and shaped implants comprising them are disclosed, as well as methods for making and using them. A cohesive mass of intertwined cartilage fibers may be shaped to provide a shaped implant which conforms to an implant site. The implant may also be reshaped to have a second shape which conforms to an implant site. The implant site may be the cavity of a cartilage defect, or a space or pocket at a treatment site, any of which may have resulted from treatment, injury, or disease. The implant may be shaped or reshaped to conform to, or replace, an anatomical feature or portion thereof, for repair or treatment of the anatomical feature. Shaped implants comprising the cartilage fibers have good shape retention and are capable of completely filling, and resisting migration from, an implant site after administration and hydration.

公开(公告)号：US20240099771A1

公开(公告)日：2024-03-28

申请号：US18370800

申请日：2023-09-20

申请人： Terra Quantum AG

发明人： Emil Sobol ,  Valerii Vinokour

IPC分类号： A61B18/20 ,  A61B17/34 ,  A61L27/36 ,  A61L27/38

CPC分类号： A61B18/20 ,  A61B17/3468 ,  A61L27/3654 ,  A61L27/3817 ,  A61B2018/00642

摘要： A laser system suitable for a treatment of a cartilage tissue in a joint includes a laser source; a feedback controller, configured to regulate a dosimetry of the laser source to produce spatially and/or temporally modulated laser light; a first optical delivery element, configured to guide the spatially and/or temporally modulated laser light to an area in the joint to irradiate a first part of the area; and a detecting element, configured to detect one or more physical, chemical, mechanical and/or structural characteristics in the area in a real-time; wherein the feedback controller is configured to regulate in a real-time the dosimetry of the laser source based on the real-time detected information pertaining to the one or more physical, chemical, mechanical and/or structural characteristics in the area for a controlled activation of a stem cell outside of the first part of the area to form a hyaline cartilage tissue.

公开(公告)号：US11918704B2

公开(公告)日：2024-03-05

申请号：US17018472

申请日：2020-09-11

申请人： Vivex Biologics Group, Inc.

发明人： Timothy Ganey

IPC分类号： A61L27/36 ,  A61L27/38

CPC分类号： A61L27/3654 ,  A61L27/3691 ,  A61L27/3895 ,  A61L2430/06 ,  A61L2430/40

摘要： A method of making infused non-demineralized cartilage fibers employs the following steps: cutting or shaving cartilage tissue into cartilage long aspect ratio fibers, washing the fibers, and infusing the fibers with a supernatant of biologic material or a polyampholyte cryoprotectant or a combination of both to create infused fibers.

公开(公告)号：US11878090B2

公开(公告)日：2024-01-23

申请号：US17471760

申请日：2021-09-10

申请人： CARTIHEAL (2009) LTD.

发明人： Nir Altschuler

IPC分类号： A61L27/36 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/12 ,  A61L27/20 ,  A61L27/40 ,  C01B25/32 ,  C01F11/18 ,  G01N1/00 ,  A61L27/50 ,  A61F2/28 ,  A61F2/30 ,  A61L27/38

CPC分类号： A61L27/3608 ,  A61F2/28 ,  A61F2/30 ,  A61F2/30756 ,  A61L27/12 ,  A61L27/20 ,  A61L27/3604 ,  A61L27/365 ,  A61L27/3637 ,  A61L27/3654 ,  A61L27/3834 ,  A61L27/40 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  C01B25/32 ,  C01F11/18 ,  G01N1/00 ,  A61F2230/0006 ,  A61F2230/0065 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0071 ,  A61F2230/0086 ,  A61L2300/112 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2430/02 ,  A61L2430/06 ,  C01P2006/90

摘要： This invention provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which said substrate is characterized by a substantial surface roughness (Ra) as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for promoting cell or tissue growth or restored function and applications of the same.

公开(公告)号：US20230310703A1

公开(公告)日：2023-10-05

申请号：US18174319

申请日：2023-02-24

申请人： Cellontech Co., Ltd.

发明人： Joon Ho LEE ,  Ji Chul YOO ,  Dong Sam SUH ,  Cheong Ho CHANG

IPC分类号： A61L27/24 ,  A61L27/36

CPC分类号： A61L27/24 ,  A61L27/362 ,  A61L27/3654 ,  A61L2400/06 ,  A61L2400/18 ,  A61L2430/06 ,  A61L2430/40

摘要： The present invention relates to a method of manufacturing collagen for restoring cartilage tissue usable for a joint in an injection manner, and a usage method thereof. The present invention provides a method of obtaining a high-concentration collagen-solution injection by aseptically filling an injection container with collagen separated from pig skin tissue, and a method of using the high-viscosity collagen loaded into the injection container for the purpose of cartilage restoration. Cartilage tissue regeneration is effectively induced when tissue restoration is implemented with respect to a cartilage-deficient portion using collagen, which is a biocompatible material, in a form that is capable of being injected into an application site with an injection needle without a surgical incision. Accordingly, restoration and regeneration of cartilage are easily and quickly induced in an animal, excluding a human, while relieving the burden related to surgery.

公开(公告)号：US20230211049A1

公开(公告)日：2023-07-06

申请号：US17479057

申请日：2021-09-20

申请人： INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY

发明人： Jangho KIM ,  Jong Keun SEON ,  Sunho PARK

IPC分类号： A61L27/38 ,  A61L27/36

CPC分类号： A61L27/3834 ,  A61L27/365 ,  A61L27/3654 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2430/02 ,  A61L2430/06

摘要： A scaffold according to an embodiment of the present disclosure is for cartilage regeneration. The scaffold may include a plurality of linear nano-patterns aligned in one direction, and stem cells adhered to the plurality of linear nano-patterns. The scaffold may improve regeneration and maturity of the cartilage, thereby being effectively used in treatment of cartilage defects.

公开(公告)号：US09981063B2

公开(公告)日：2018-05-29

申请号：US11286593

申请日：2005-11-23

申请人： Shawn W. O'Driscoll ,  David G. Lewallen ,  Rodrigo Mardones

发明人： Shawn W. O'Driscoll ,  David G. Lewallen ,  Rodrigo Mardones

IPC分类号： A61F2/28 ,  A61L27/36 ,  A61F2/30 ,  A61L27/42 ,  A61L27/56 ,  A61F2/46

CPC分类号： A61L27/3683 ,  A61F2/30756 ,  A61F2/468 ,  A61F2002/2817 ,  A61F2002/30764 ,  A61F2002/30766 ,  A61F2310/00131 ,  A61F2310/00365 ,  A61L27/3604 ,  A61L27/365 ,  A61L27/3654 ,  A61L27/427 ,  A61L27/56

摘要： A composite for osteochondral defect repair includes a porous scaffold and a periosteal graft secured to a surface of the scaffold. The composite provides cartilage growth from autologous periosteum chondrogenesis. Biological resurfacing of large osteochondral defects, or a complete joint is feasible using the porous scaffold/autologous periosteal composite. The use of this composite eliminates the necessity of using normal cartilage surface as a donor site and its respective associated morbidity. In one form, the strong bone integration capacity of a porous metal (e.g., tantalum) scaffold and the high grade of integration observed from periosteal chondrogenesis into the normal cartilage eliminates the lack of chondral-chondral integration observed in the autologous osteochondral graft technique.

公开(公告)号：US09744043B2

公开(公告)日：2017-08-29

申请号：US11826518

申请日：2007-07-16

申请人： Silvia S. Chen ,  Xiaofei Qin ,  Jingsong Chen ,  Lloyd Wolfinbarger, Jr.

发明人： Silvia S. Chen ,  Xiaofei Qin ,  Jingsong Chen ,  Lloyd Wolfinbarger, Jr.

IPC分类号： A61F2/28 ,  A61F2/30 ,  A61B17/16 ,  A61F2/46 ,  A61L27/36 ,  A61L27/38 ,  A61F2/38

CPC分类号： A61F2/30756 ,  A61B17/1604 ,  A61B17/1635 ,  A61B17/1675 ,  A61F2/28 ,  A61F2/30749 ,  A61F2/3094 ,  A61F2/38 ,  A61F2/3859 ,  A61F2/4644 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30004 ,  A61F2002/30224 ,  A61F2002/30235 ,  A61F2002/30751 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/4646 ,  A61F2002/4648 ,  A61F2002/4649 ,  A61F2230/0069 ,  A61F2250/0014 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/3804 ,  A61L2430/06

摘要： The invention is directed to producing a shaped cartilage matrix isolated from a human or animal where the cartilage has been crafted to facilitate disinfection, cleaning, devitalization, recellularization, and/or integration after implantation. The invention relates to a process for repairing a cartilage defect and implantation of a cartilage graft into a human or animal by crafting the cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation. The devitalized cartilage graft is also optionally stored between the removing cellular debris and the recellularizing steps.

公开(公告)号：US09539364B2

公开(公告)日：2017-01-10

申请号：US11663582

申请日：2005-09-23

申请人： Anthony P. Hollander ,  Wa'el Z. Kafeinah ,  Ehsanollah Esfandiari ,  John F. Tarlton

发明人： Anthony P. Hollander ,  Wa'el Z. Kafeinah ,  Ehsanollah Esfandiari ,  John F. Tarlton

IPC分类号： C12N5/00 ,  A61K9/70 ,  A61L27/38 ,  A61L27/36 ,  A61L31/00

CPC分类号： A61L27/3817 ,  A61F2/30756 ,  A61F2/3872 ,  A61L27/18 ,  A61L27/3612 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/3654 ,  A61L27/3843 ,  A61L27/58 ,  A61L31/005 ,  A61L2300/412 ,  A61L2300/64 ,  A61L2430/06

摘要： The invention provides a method for delivering cells across the surface of a tissue, the method comprising distributing the cells on and/or within a sheet of biomaterial to form a cell bandage and applying the cell bandage to the surface, wherein, after application of the cell bandage to the surface of the tissue, the cells are released from the cell bandage. Further provided is a method for bonding two or more tissues, the method comprising providing a cell bandage in intimate contact with the surfaces to be joined, wherein the cell bandage comprises a sheet of biomaterial, said biomaterial having cells distributed on and/or within it. Also provided is a cell bandage for use in the methods of the invention.

摘要翻译： 本发明提供了一种用于在组织表面递送细胞的方法，所述方法包括将细胞分布在生物材料片材上和/或内部以形成细胞绷带并将细胞绷带施加到表面，其中在施用 细胞绷带到组织的表面，细胞从细胞绷带释放。 还提供了一种用于粘合两个或更多个组织的方法，所述方法包括提供与要接合的表面紧密接触的细胞绷带，其中所述细胞绷带包括生物材料片，所述生物材料具有分布在其上和/或内部的细胞 。 还提供了用于本发明方法的细胞绷带。

公开(公告)号：US20160095956A1

公开(公告)日：2016-04-07

申请号：US14892529

申请日：2014-06-16

申请人： VIDEREGEN LIMITED

发明人： Tahera Iqbal ANSARI ,  Paul David SIBBONS

IPC分类号： A61L27/36

CPC分类号： A61L27/3683 ,  A61L27/365 ,  A61L27/3654 ,  A61L27/3662 ,  A61L27/3687 ,  A61L27/3691 ,  A61L2430/02

摘要： The invention provides a method for producing an implant from interstitial, connective or supporting tissue, the method comprising at least one step of perfusing the tissue with at least one decellularisation medium under negative pressure applied for substantially the whole time period of the perfusion.

摘要翻译： 本发明提供了一种用于从间质，结缔组织或支持组织生产植入物的方法，所述方法包括至少一个步骤，在基本上灌注整个时间段内施加负压的至少一种脱细胞培养基灌注组织。